Gene description for Krt14
Gene name keratin 14
Gene symbol Krt14
Other names/aliases AI626930
K14
Krt-1.14
Krt1-14
Species Mus musculus
 Database cross references - Krt14
ExoCarta ExoCarta_16664
Vesiclepedia VP_16664
Entrez Gene 16664
UniProt Q61781  
 Krt14 identified in sEVs derived from the following tissue/cell type
Oligodendrocytes 21136642    
 Gene ontology annotations for Krt14
Molecular Function
    structural molecule activity GO:0005198 IEA
    protein binding GO:0005515 IPI
    keratin filament binding GO:1990254 IEA
    keratin filament binding GO:1990254 ISO
Biological Process
    response to radiation GO:0009314 IDA
    keratinocyte differentiation GO:0030216 IDA
    epithelial cell differentiation GO:0030855 IBA
    epithelial cell differentiation GO:0030855 ISO
    hair cycle GO:0042633 IEA
    hair cycle GO:0042633 ISO
    intermediate filament organization GO:0045109 IBA
    intermediate filament bundle assembly GO:0045110 ISO
    intermediate filament bundle assembly GO:0045110 ISS
    stem cell differentiation GO:0048863 IDA
Subcellular Localization
    cornified envelope GO:0001533 IDA
    intracellular anatomical structure GO:0005622 IDA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    cytoskeleton GO:0005856 IBA
    intermediate filament GO:0005882 ISO
    keratin filament GO:0045095 IBA
    keratin filament GO:0045095 IDA
    keratin filament GO:0045095 ISO
    basal part of cell GO:0045178 IDA
    cell periphery GO:0071944 IDA
 Experiment description of studies that identified Krt14 in sEVs
1
Experiment ID 33
MISEV standards
EM|IEM
Biophysical techniques
Alix|TSG101
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors "Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J"
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Krt14
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Invs  
Affinity Capture-MS Mus musculus
2 Eps15 13858
Co-fractionation Mus musculus
3 Nphp4  
Affinity Capture-MS Mus musculus
4 Atxn1  
Proximity Label-MS Mus musculus
5 Kctd13  
Affinity Capture-MS Mus musculus
6 Thrb  
Affinity Capture-MS Mus musculus
7 Ahi1  
Affinity Capture-MS Mus musculus
8 Pkp1  
Co-fractionation Mus musculus
9 Mks1  
Affinity Capture-MS Mus musculus
10 Iqcb1  
Affinity Capture-MS Mus musculus
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