Gene description for DEFA3
Gene name defensin, alpha 3, neutrophil-specific
Gene symbol DEFA3
Other names/aliases DEF3
HNP-3
HNP3
HP-3
HP3
Species Homo sapiens
 Database cross references - DEFA3
ExoCarta ExoCarta_1668
Entrez Gene 1668
HGNC 2762
MIM 604522
UniProt P59666  
 DEFA3 identified in exosomes derived from the following tissue/cell type
Urine 15326289    
 Gene ontology annotations for DEFA3
Molecular Function
    molecular_function GO:0003674 ND
Biological Process
    defense response to Gram-positive bacterium GO:0050830 IDA
    defense response to virus GO:0051607 IEA
    innate immune response GO:0045087 TAS
    intracellular estrogen receptor signaling pathway GO:0030520 IDA
    killing of cells of other organism GO:0031640 IEA
    defense response to fungus GO:0050832 IEA
    innate immune response in mucosa GO:0002227 IDA
    antibacterial humoral response GO:0019731 IDA
Subcellular Localization
    azurophil granule lumen GO:0035578 TAS
    extracellular region GO:0005576 TAS
    extracellular exosome GO:0070062 IDA
    extracellular space GO:0005615 IDA
    Golgi lumen GO:0005796 TAS
 Experiment description of studies that identified DEFA3 in exosomes
1
Experiment ID 13
ISEV standards
IEM
EV Biophysical techniques
Alix|RAB4|RAB5B|RAB11|TSG101
EV Cytosolic markers
CD9|AQP2|AQP1
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15326289    
Organism Homo sapiens
Experiment description Identification and proteomic profiling of exosomes in human urine.
Authors Pisitkun T, Shen RF, Knepper MA
Journal name PNAS
Publication year 2004
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
 Protein-protein interactions for DEFA3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which DEFA3 is involved
PathwayEvidenceSource
Alpha-defensins TAS Reactome
Defensins TAS Reactome





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