Gene description for Lta4h
Gene name leukotriene A4 hydrolase
Gene symbol Lta4h
Other names/aliases -
Species Mus musculus
 Database cross references - Lta4h
ExoCarta ExoCarta_16993
Vesiclepedia VP_16993
Entrez Gene 16993
UniProt P24527  
 Lta4h identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Lta4h
Molecular Function
    aminopeptidase activity GO:0004177 IBA
    aminopeptidase activity GO:0004177 ISO
    aminopeptidase activity GO:0004177 ISS
    epoxide hydrolase activity GO:0004301 IBA
    epoxide hydrolase activity GO:0004301 ISO
    epoxide hydrolase activity GO:0004301 ISS
    leukotriene-A4 hydrolase activity GO:0004463 IBA
    leukotriene-A4 hydrolase activity GO:0004463 ISO
    leukotriene-A4 hydrolase activity GO:0004463 ISS
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 ISO
    zinc ion binding GO:0008270 ISS
    tripeptide aminopeptidase activity GO:0045148 IEA
    metalloaminopeptidase activity GO:0070006 IEA
    metalloaminopeptidase activity GO:0070006 ISO
Biological Process
    proteolysis GO:0006508 IEA
    leukotriene metabolic process GO:0006691 ISO
    response to zinc ion GO:0010043 IEA
    leukotriene biosynthetic process GO:0019370 IBA
    leukotriene biosynthetic process GO:0019370 ISO
    leukotriene biosynthetic process GO:0019370 ISS
    protein metabolic process GO:0019538 ISO
    peptide catabolic process GO:0043171 IBA
    peptide catabolic process GO:0043171 ISO
    peptide catabolic process GO:0043171 ISS
    response to peptide hormone GO:0043434 IEA
    type I pneumocyte differentiation GO:0060509 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Lta4h in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Lta4h
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ankfy1 11736
Co-fractionation Mus musculus
2 Ufc1  
Co-fractionation Mus musculus
3 Ufm1  
Co-fractionation Mus musculus
View the network image/svg+xml



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