Gene description for Lta4h
Gene name leukotriene A4 hydrolase
Gene symbol Lta4h
Other names/aliases -
Species Mus musculus
 Database cross references - Lta4h
ExoCarta ExoCarta_16993
Vesiclepedia VP_16993
Entrez Gene 16993
UniProt P24527  
 Lta4h identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Lta4h
Molecular Function
    zinc ion binding GO:0008270 ISO
    leukotriene-A4 hydrolase activity GO:0004463 ISO
    protein binding GO:0005515 IPI
    epoxide hydrolase activity GO:0004301 ISO
    metallopeptidase activity GO:0008237 IEA
    peptidase activity GO:0008233 IEA
    poly(A) RNA binding GO:0044822 ISO
    metal ion binding GO:0046872 IEA
    aminopeptidase activity GO:0004177 ISO
    hydrolase activity GO:0016787 IEA
Biological Process
    leukotriene biosynthetic process GO:0019370 ISO
    peptide catabolic process GO:0043171 ISO
    proteolysis GO:0006508 ISO
    leukotriene metabolic process GO:0006691 ISO
Subcellular Localization
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
    nucleus GO:0005634 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Lta4h in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Lta4h
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Lta4h is involved
PathwayEvidenceSource
Synthesis of Leukotrienes (LT) and Eoxins (EX) IEA Reactome





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