Gene description for Alad
Gene name aminolevulinate, delta-, dehydratase
Gene symbol Alad
Other names/aliases ALADH
Lv
Species Mus musculus
 Database cross references - Alad
ExoCarta ExoCarta_17025
Entrez Gene 17025
UniProt P10518  
 Alad identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Alad
Molecular Function
    metal ion binding GO:0046872 IEA
    catalytic activity GO:0003824 IEA
    lyase activity GO:0016829 IEA
    identical protein binding GO:0042802 ISO
    porphobilinogen synthase activity GO:0004655 ISO
    zinc ion binding GO:0008270 ISO
    lead ion binding GO:0032791 ISO
Biological Process
    response to organic substance GO:0010033 ISO
    porphyrin-containing compound biosynthetic process GO:0006779 IEA
    response to ethanol GO:0045471 ISO
    response to nutrient GO:0007584 ISO
    response to arsenic-containing substance GO:0046685 ISO
    protein homooligomerization GO:0051260 ISO
    response to drug GO:0042493 ISO
    response to cadmium ion GO:0046686 ISO
    response to metal ion GO:0010038 ISO
    metabolic process GO:0008152 IEA
    cellular response to interleukin-4 GO:0071353 IDA
    heme biosynthetic process GO:0006783 ISO
    tetrapyrrole biosynthetic process GO:0033014 IEA
    response to zinc ion GO:0010043 ISO
Subcellular Localization
    extracellular space GO:0005615 ISO
    extracellular exosome GO:0070062 ISO
    nucleus GO:0005634 ISO
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Alad in exosomes
1
Experiment ID 188
ISEV standards
EM
EV Biophysical techniques
GAPDH|UCHL1|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Alad
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Alad is involved
PathwayEvidenceSource
Heme biosynthesis IEA Reactome





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