Gene description for Map2k1
Gene name	mitogen activated protein kinase kinase 1
Gene symbol	Map2k1
Other names/aliases	Mek1
Species	Rattus norvegicus
Database cross references - Map2k1
ExoCarta	ExoCarta_170851
Vesiclepedia	VP_170851
Entrez Gene	170851
UniProt	Q01986
Map2k1 identified in exosomes derived from the following tissue/cell type
Reticulocytes	21828046

Gene ontology annotations for Map2k1

Molecular Function     protein serine/threonine kinase activity GO:0004674 IEA     protein serine/threonine kinase activity GO:0004674 ISO     MAP kinase kinase activity GO:0004708 IBA     MAP kinase kinase activity GO:0004708 IDA     MAP kinase kinase activity GO:0004708 IEA     MAP kinase kinase activity GO:0004708 ISO     MAP kinase kinase activity GO:0004708 TAS     protein serine/threonine/tyrosine kinase activity GO:0004712 TAS     protein tyrosine kinase activity GO:0004713 IEA     MAP-kinase scaffold activity GO:0005078 IEA     MAP-kinase scaffold activity GO:0005078 ISO     protein binding GO:0005515 IPI     ATP binding GO:0005524 IDA     ATP binding GO:0005524 IEA     JUN kinase kinase activity GO:0008545 IEA     protein kinase binding GO:0019901 IPI     protein kinase activator activity GO:0030295 ISO     small GTPase binding GO:0031267 IPI     mitogen-activated protein kinase kinase kinase binding GO:0031435 IDA     mitogen-activated protein kinase kinase kinase binding GO:0031435 IPI     histone H3Y41 kinase activity GO:0035401 IEA     protein serine/threonine kinase activator activity GO:0043539 IEA     protein serine/threonine kinase activator activity GO:0043539 ISO     protein-containing complex binding GO:0044877 IPI     scaffold protein binding GO:0097110 IEA     scaffold protein binding GO:0097110 ISO     protein serine kinase activity GO:0106310 IEA     histone H2AXY142 kinase activity GO:0140801 IEA Biological Process     MAPK cascade GO:0000165 IBA     MAPK cascade GO:0000165 IEA     MAPK cascade GO:0000165 ISO     regulation of vascular associated smooth muscle contraction GO:0003056 IMP     chromatin remodeling GO:0006338 IEA     protein phosphorylation GO:0006468 IDA     protein phosphorylation GO:0006468 ISO     protein phosphorylation GO:0006468 TAS     response to oxidative stress GO:0006979 IDA     JNK cascade GO:0007254 IEA     heart development GO:0007507 IEA     heart development GO:0007507 ISO     negative regulation of cell population proliferation GO:0008285 IEA     negative regulation of cell population proliferation GO:0008285 ISO     positive regulation of autophagy GO:0010508 IDA     positive regulation of gene expression GO:0010628 IEA     positive regulation of gene expression GO:0010628 IGI     positive regulation of gene expression GO:0010628 IMP     positive regulation of gene expression GO:0010628 ISO     negative regulation of gene expression GO:0010629 IGI     Schwann cell development GO:0014044 IEA     Schwann cell development GO:0014044 ISO     cerebellar cortex formation GO:0021697 IEA     cerebellar cortex formation GO:0021697 ISO     neuron differentiation GO:0030182 IBA     neuron differentiation GO:0030182 IEA     neuron differentiation GO:0030182 IMP     neuron differentiation GO:0030182 ISO     keratinocyte differentiation GO:0030216 IEA     keratinocyte differentiation GO:0030216 ISO     positive regulation of cell migration GO:0030335 IMP     thyroid gland development GO:0030878 IEA     thyroid gland development GO:0030878 ISO     melanosome transport GO:0032402 IDA     regulation of stress-activated MAPK cascade GO:0032872 IEA     regulation of stress-activated MAPK cascade GO:0032872 TAS     positive regulation of transcription elongation by RNA polymerase II GO:0032968 IMP     negative regulation of homotypic cell-cell adhesion GO:0034111 IMP     intracellular signal transduction GO:0035556 TAS     endodermal cell differentiation GO:0035987 IEA     endodermal cell differentiation GO:0035987 ISO     ERBB2-ERBB3 signaling pathway GO:0038133 IEA     ERBB2-ERBB3 signaling pathway GO:0038133 ISO     myelination GO:0042552 IEA     myelination GO:0042552 ISO     positive regulation of MAPK cascade GO:0043410 IDA     positive regulation of MAPK cascade GO:0043410 ISO     positive regulation of GTPase activity GO:0043547 IMP     type B pancreatic cell proliferation GO:0044342 IEA     type B pancreatic cell proliferation GO:0044342 ISO     positive regulation of DNA-templated transcription GO:0045893 IEA     positive regulation of DNA-templated transcription GO:0045893 ISO     positive regulation of muscle contraction GO:0045933 IGI     positive regulation of muscle contraction GO:0045933 IMP     positive regulation of Ras protein signal transduction GO:0046579 IMP     vesicle transport along microtubule GO:0047496 IDA     insulin-like growth factor receptor signaling pathway GO:0048009 IEA     insulin-like growth factor receptor signaling pathway GO:0048009 ISO     Golgi inheritance GO:0048313 IMP     thymus development GO:0048538 IEA     thymus development GO:0048538 ISO     response to axon injury GO:0048678 IMP     regulation of axon regeneration GO:0048679 IEA     regulation of axon regeneration GO:0048679 ISO     neuron projection morphogenesis GO:0048812 IMP     cell motility GO:0048870 IEA     cell motility GO:0048870 ISO     positive regulation of axonogenesis GO:0050772 IEA     positive regulation of axonogenesis GO:0050772 ISO     response to glucocorticoid GO:0051384 IDA     Bergmann glial cell differentiation GO:0060020 IEA     Bergmann glial cell differentiation GO:0060020 ISO     face development GO:0060324 IEA     face development GO:0060324 ISO     lung morphogenesis GO:0060425 ISO     trachea formation GO:0060440 IEA     trachea formation GO:0060440 ISO     epithelial cell proliferation involved in lung morphogenesis GO:0060502 IEA     epithelial cell proliferation involved in lung morphogenesis GO:0060502 ISO     placenta blood vessel development GO:0060674 IEA     placenta blood vessel development GO:0060674 ISO     labyrinthine layer development GO:0060711 IEA     labyrinthine layer development GO:0060711 ISO     triglyceride homeostasis GO:0070328 IDA     ERK1 and ERK2 cascade GO:0070371 IEA     ERK1 and ERK2 cascade GO:0070371 ISO     regulation of ERK1 and ERK2 cascade GO:0070372 IDA     positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO     positive regulation of protein serine/threonine kinase activity GO:0071902 ISO     regulation of Golgi inheritance GO:0090170 IEA     regulation of Golgi inheritance GO:0090170 TAS     cellular senescence GO:0090398 IEA     cellular senescence GO:0090398 ISO     regulation of neurotransmitter receptor localization to postsynaptic specialization membrane GO:0098696 EXP     regulation of neurotransmitter receptor localization to postsynaptic specialization membrane GO:0098696 IDA     positive regulation of endodermal cell differentiation GO:1903226 IEA     positive regulation of endodermal cell differentiation GO:1903226 ISO     negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway GO:1903298 IGI     negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway GO:1903298 IMP     regulation of early endosome to late endosome transport GO:2000641 IEA     regulation of early endosome to late endosome transport GO:2000641 TAS     positive regulation of ATP biosynthetic process GO:2001171 IGI     positive regulation of ATP biosynthetic process GO:2001171 IMP Subcellular Localization     nucleus GO:0005634 IEA     nucleus GO:0005634 TAS     mitochondrion GO:0005739 IEA     mitochondrion GO:0005739 TAS     early endosome GO:0005769 IEA     early endosome GO:0005769 TAS     late endosome GO:0005770 IEA     late endosome GO:0005770 TAS     endoplasmic reticulum GO:0005783 IEA     endoplasmic reticulum GO:0005783 ISO     Golgi apparatus GO:0005794 TAS     centrosome GO:0005813 IEA     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     cytosol GO:0005829 TAS     microtubule GO:0005874 IDA     plasma membrane GO:0005886 IEA     plasma membrane GO:0005886 ISO     focal adhesion GO:0005925 IEA     focal adhesion GO:0005925 TAS     cell cortex GO:0005938 IDA     postsynaptic density GO:0014069 IDA     membrane GO:0016020 IEA     axon GO:0030424 IDA     dendrite GO:0030425 IDA     dendrite cytoplasm GO:0032839 IDA     perikaryon GO:0043204 IDA     perinuclear region of cytoplasm GO:0048471 IDA     glutamatergic synapse GO:0098978 EXP     glutamatergic synapse GO:0098978 IDA