Gene description for Map2k1
Gene name	mitogen activated protein kinase kinase 1
Gene symbol	Map2k1
Other names/aliases	Mek1
Species	Rattus norvegicus
Database cross references - Map2k1
ExoCarta	ExoCarta_170851
Entrez Gene	170851
UniProt	Q01986
Map2k1 identified in exosomes derived from the following tissue/cell type
Reticulocytes	21828046

Gene ontology annotations for Map2k1

Molecular Function     mitogen-activated protein kinase kinase kinase binding GO:0031435 IPI     protein tyrosine kinase activity GO:0004713 IEA     protein binding GO:0005515 IPI     MAP kinase kinase activity GO:0004708 TAS     protein kinase binding GO:0019901 IPI     protein serine/threonine kinase activator activity GO:0043539 ISO     receptor signaling protein tyrosine phosphatase activity GO:0004728 ISO     protein serine/threonine kinase activity GO:0004674 IEA     Ras GTPase binding GO:0017016 IPI     protein serine/threonine/tyrosine kinase activity GO:0004712 TAS     ATP binding GO:0005524 IDA     protein N-terminus binding GO:0047485 ISO     protein C-terminus binding GO:0008022 ISO Biological Process     regulation of axon regeneration GO:0048679 ISO     neuron projection morphogenesis GO:0048812 IMP     Golgi inheritance GO:0048313 IMP     response to axon injury GO:0048678 IMP     negative regulation of cell proliferation GO:0008285 ISO     cell motility GO:0048870 ISO     positive regulation of transcription elongation from RNA polymerase II promoter GO:0032968 IMP     positive regulation of protein serine/threonine kinase activity GO:0071902 ISO     keratinocyte differentiation GO:0030216 ISO     regulation of Golgi inheritance GO:0090170 TAS     lung morphogenesis GO:0060425 ISO     protein heterooligomerization GO:0051291 IPI     melanosome transport GO:0032402 IDA     peptidyl-tyrosine dephosphorylation GO:0035335 ISO     protein phosphorylation GO:0006468 TAS     regulation of protein phosphorylation GO:0001932 ISO     positive regulation of cell differentiation GO:0045597 ISO     cell cycle arrest GO:0007050 ISO     cell proliferation GO:0008283 IDA     mitotic nuclear division GO:0007067 IDA     positive regulation of Ras protein signal transduction GO:0046579 IMP     cellular senescence GO:0090398 ISO     response to glucocorticoid GO:0051384 IDA     neuron differentiation GO:0030182 ISO     regulation of stress-activated MAPK cascade GO:0032872 TAS     positive regulation of cell migration GO:0030335 IMP     positive regulation of GTPase activity GO:0043547 IMP     response to oxidative stress GO:0006979 IDA     regulation of vascular smooth muscle contraction GO:0003056 IMP     placenta blood vessel development GO:0060674 ISO     positive regulation of gene expression GO:0010628 ISO     positive regulation of axonogenesis GO:0050772 ISO     ERK1 and ERK2 cascade GO:0070371 ISO     intracellular signal transduction GO:0035556 TAS     activation of mitophagy in response to mitochondrial depolarization GO:0098779 ISO     MAPK cascade GO:0000165 ISO     activation of MAPK activity GO:0000187 TAS     vesicle transport along microtubule GO:0047496 IDA     regulation of early endosome to late endosome transport GO:2000641 TAS     labyrinthine layer development GO:0060711 ISO     epithelial cell proliferation involved in lung morphogenesis GO:0060502 ISO     negative regulation of homotypic cell-cell adhesion GO:0034111 IMP     trachea formation GO:0060440 ISO     peptidyl-tyrosine phosphorylation GO:0018108 IEA Subcellular Localization     nucleus GO:0005634 TAS     intracellular GO:0005622 ISO     focal adhesion GO:0005925 TAS     perinuclear region of cytoplasm GO:0048471 IDA     Golgi apparatus GO:0005794 TAS     endoplasmic reticulum GO:0005783 ISO     microtubule GO:0005874 IDA     late endosome GO:0005770 TAS     early endosome GO:0005769 TAS     cytosol GO:0005829 TAS     perikaryon GO:0043204 IDA     plasma membrane GO:0005886 ISO     dendrite GO:0030425 IDA     axon GO:0030424 IDA     mitochondrion GO:0005739 TAS     microtubule organizing center GO:0005815 IEA     cytoplasm GO:0005737 ISO     dendrite cytoplasm GO:0032839 IDA     extracellular exosome GO:0070062 ISO     cell cortex GO:0005938 IDA