Gene description for Asic3
Gene name acid-sensing (proton-gated) ion channel 3
Gene symbol Asic3
Other names/aliases AW742291
Accn3
DRASIC
SLNAC1
TNAC1
Species Mus musculus
 Database cross references - Asic3
ExoCarta ExoCarta_171209
Entrez Gene 171209
UniProt Q6X1Y6  
 Asic3 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Asic3
Molecular Function
    ligand-gated sodium channel activity GO:0015280 ISO
    sodium channel activity GO:0005272 IEA
    enterobactin transporter activity GO:0042931 IMP
    cation channel activity GO:0005261 TAS
    PDZ domain binding GO:0030165 ISO
Biological Process
    detection of mechanical stimulus involved in sensory perception GO:0050974 IMP
    ion transport GO:0006811 IEA
    detection of mechanical stimulus involved in sensory perception of pain GO:0050966 IMP
    detection of chemical stimulus involved in sensory perception GO:0050907 IMP
    transport GO:0006810 IEA
    detection of temperature stimulus involved in sensory perception GO:0050961 IMP
    cation transmembrane transport GO:0098655 IMP
    response to mechanical stimulus GO:0009612 IMP
    enterobactin transport GO:0042930 IMP
    cation transport GO:0006812 IMP
    sensory perception of sour taste GO:0050915 ISO
    response to heat GO:0009408 IMP
    response to acidic pH GO:0010447 ISO
    detection of chemical stimulus involved in sensory perception of pain GO:0050968 IMP
    detection of temperature stimulus involved in sensory perception of pain GO:0050965 IMP
    ion transmembrane transport GO:0034220 IMP
    sodium ion transmembrane transport GO:0035725 ISO
    sodium ion transport GO:0006814 ISO
Subcellular Localization
    cytoplasm GO:0005737 IEA
    integral component of plasma membrane GO:0005887 ISO
    integral component of membrane GO:0016021 IEA
    plasma membrane GO:0005886 IEA
    membrane GO:0016020 IEA
 Experiment description of studies that identified Asic3 in exosomes
1
Experiment ID 210
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD81|FLOT1
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Asic3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Asic3 is involved
PathwayEvidenceSource
Stimuli-sensing channels IEA Reactome





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