Gene description for Asic3
Gene name acid-sensing (proton-gated) ion channel 3
Gene symbol Asic3
Other names/aliases AW742291
Accn3
DRASIC
SLNAC1
TNAC1
Species Mus musculus
 Database cross references - Asic3
ExoCarta ExoCarta_171209
Vesiclepedia VP_171209
Entrez Gene 171209
UniProt Q6X1Y6  
 Asic3 identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Asic3
Molecular Function
    monoatomic cation channel activity GO:0005261 IDA
    monoatomic cation channel activity GO:0005261 IMP
    monoatomic cation channel activity GO:0005261 TAS
    ligand-gated sodium channel activity GO:0015280 IBA
    ligand-gated sodium channel activity GO:0015280 ISO
    enterobactin transmembrane transporter activity GO:0042931 IMP
Biological Process
    monoatomic cation transport GO:0006812 IDA
    monoatomic cation transport GO:0006812 IMP
    sodium ion transport GO:0006814 ISO
    sodium ion transport GO:0006814 ISO
    response to heat GO:0009408 IMP
    response to mechanical stimulus GO:0009612 IMP
    response to acidic pH GO:0010447 IDA
    response to acidic pH GO:0010447 IMP
    response to acidic pH GO:0010447 ISO
    monoatomic ion transmembrane transport GO:0034220 IMP
    monoatomic ion transmembrane transport GO:0034220 ISO
    sodium ion transmembrane transport GO:0035725 IBA
    sodium ion transmembrane transport GO:0035725 IEA
    enterobactin transport GO:0042930 IEA
    detection of chemical stimulus involved in sensory perception GO:0050907 IMP
    sensory perception of sour taste GO:0050915 IEA
    sensory perception of sour taste GO:0050915 ISO
    detection of temperature stimulus involved in sensory perception GO:0050961 IMP
    detection of temperature stimulus involved in sensory perception of pain GO:0050965 IMP
    detection of mechanical stimulus involved in sensory perception of pain GO:0050966 IMP
    detection of chemical stimulus involved in sensory perception of pain GO:0050968 IMP
    detection of mechanical stimulus involved in sensory perception GO:0050974 IMP
    establishment of localization in cell GO:0051649 IMP
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    perinuclear region of cytoplasm GO:0048471 IEA
    perinuclear region of cytoplasm GO:0048471 ISO
 Experiment description of studies that identified Asic3 in sEVs
1
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Asic3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Stoml1  
Co-fractionation Mus musculus
2 Stom 13830
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Asic3 is involved
PathwayEvidenceSource
Ion channel transport IEA Reactome
Stimuli-sensing channels IEA Reactome
Transport of small molecules IEA Reactome





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