Gene description for Myo10
Gene name myosin X
Gene symbol Myo10
Other names/aliases AW048724
D15Ertd600e
mKIAA0799
Species Mus musculus
 Database cross references - Myo10
ExoCarta ExoCarta_17909
Vesiclepedia VP_17909
Entrez Gene 17909
UniProt F8VQB6  
 Myo10 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Myo10
Molecular Function
    protein binding GO:0005515 IPI
    actin filament binding GO:0051015 ISO
    calmodulin binding GO:0005516 IEA
    nucleotide binding GO:0000166 IEA
    ATP binding GO:0005524 IEA
    actin binding GO:0003779 IEA
    spectrin binding GO:0030507 ISO
    motor activity GO:0003774 IEA
Biological Process
    transport GO:0006810 IEA
    positive regulation of cell-cell adhesion GO:0022409 IGI
    regulation of filopodium assembly GO:0051489 ISO
    cell motility GO:0048870 IC
    regulation of cell shape GO:0008360 ISO
Subcellular Localization
    neuronal cell body GO:0043025 IDA
    cell projection GO:0042995 IEA
    myosin complex GO:0016459 IEA
    plasma membrane GO:0005886 ISO
    cytoplasm GO:0005737 ISO
    cytoskeleton GO:0005856 IEA
    neuron projection GO:0043005 IDA
    lamellipodium GO:0030027 ISO
    membrane GO:0016020 IEA
    ruffle GO:0001726 ISO
    filopodium GO:0030175 IDA
    nucleolus GO:0005730 ISO
 Experiment description of studies that identified Myo10 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Myo10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DYNLL1 8655
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which Myo10 is involved
PathwayEvidenceSource
Regulation of actin dynamics for phagocytic cup formation IEA Reactome





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