Gene description for Ndrg1
Gene name N-myc downstream regulated gene 1
Gene symbol Ndrg1
Other names/aliases CAP43
CMT4D
DRG1
HMSNL
NMSL
Ndr1
Ndrl
PROXY1
RTP
TDD5
Species Mus musculus
 Database cross references - Ndrg1
ExoCarta ExoCarta_17988
Vesiclepedia VP_17988
Entrez Gene 17988
UniProt Q62433  
 Ndrg1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ndrg1
Molecular Function
    cadherin binding GO:0045296 ISO
    gamma-tubulin binding GO:0043015 ISO
    microtubule binding GO:0008017 ISO
    Rab GTPase binding GO:0017137 ISO
Biological Process
    peripheral nervous system myelin maintenance GO:0032287 IMP
    mast cell activation GO:0045576 IDA
    positive regulation of spindle checkpoint GO:0090232 ISO
    signal transduction GO:0007165 IBA
Subcellular Localization
    centrosome GO:0005813 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    membrane GO:0016020 IEA
    microtubule GO:0005874 ISO
    cytoplasm GO:0005737 ISO
    cytoskeleton GO:0005856 IEA
    microtubule cytoskeleton GO:0015630 ISO
    plasma membrane GO:0005886 ISO
    cell-cell adherens junction GO:0005913 ISO
    nucleus GO:0005634 ISO
    recycling endosome membrane GO:0055038 ISO
    extracellular exosome GO:0070062 ISO
    myelin sheath GO:0043209 IDA
 Experiment description of studies that identified Ndrg1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ndrg1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ndrg1 is involved
No pathways found





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