Gene description for Nrp1
Gene name neuropilin 1
Gene symbol Nrp1
Other names/aliases C530029I03
NP-1
NPN-1
Npn1
Nrp
Species Mus musculus
 Database cross references - Nrp1
ExoCarta ExoCarta_18186
Entrez Gene 18186
UniProt P97333  
 Nrp1 identified in exosomes derived from the following tissue/cell type
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
 Gene ontology annotations for Nrp1
Molecular Function
    heparin binding GO:0008201 IEA
    vascular endothelial growth factor binding GO:0038085 ISO
    metal ion binding GO:0046872 IEA
    vascular endothelial growth factor-activated receptor activity GO:0005021 ISO
    semaphorin receptor activity GO:0017154 ISO
    protein binding GO:0005515 IPI
    growth factor binding GO:0019838 ISO
Biological Process
    sympathetic neuron projection extension GO:0097490 IMP
    trigeminal nerve morphogenesis GO:0021636 IMP
    ganglion morphogenesis GO:0061552 IMP
    hepatocyte growth factor receptor signaling pathway GO:0048012 ISO
    vascular endothelial growth factor signaling pathway GO:0038084 ISO
    neural crest cell migration involved in autonomic nervous system development GO:1901166 IMP
    semaphorin-plexin signaling pathway GO:0071526 IPI
    angiogenesis involved in coronary vascular morphogenesis GO:0060978 IMP
    patterning of blood vessels GO:0001569 IMP
    retina vasculature morphogenesis in camera-type eye GO:0061299 IMP
    vestibulocochlear nerve structural organization GO:0021649 IMP
    cellular response to hepatocyte growth factor stimulus GO:0035729 ISO
    retinal ganglion cell axon guidance GO:0031290 IMP
    ventral trunk neural crest cell migration GO:0036486 IMP
    nerve development GO:0021675 IMP
    positive regulation of retinal ganglion cell axon guidance GO:1902336 IMP
    regulation of retinal ganglion cell axon guidance GO:0090259 IMP
    peptidyl-tyrosine phosphorylation GO:0018108 IMP
    sensory neuron axon guidance GO:0097374 IMP
    VEGF-activated neuropilin signaling pathway involved in axon guidance GO:1902378 IMP
    neuron migration GO:0001764 IMP
    facial nerve structural organization GO:0021612 IMP
    sympathetic nervous system development GO:0048485 IMP
    cell differentiation GO:0030154 IEA
    sprouting angiogenesis GO:0002040 IMP
    semaphorin-plexin signaling pathway involved in axon guidance GO:1902287 IMP
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP
    cell migration GO:0016477 IMP
    angiogenesis GO:0001525 ISO
    axon extension involved in axon guidance GO:0048846 IMP
    coronary artery morphogenesis GO:0060982 IMP
    vascular endothelial growth factor receptor signaling pathway GO:0048010 ISO
    axonogenesis involved in innervation GO:0060385 IMP
    dichotomous subdivision of terminal units involved in salivary gland branching GO:0060666 IMP
    branchiomotor neuron axon guidance GO:0021785 IMP
    otic placode formation GO:0043049 IMP
    negative regulation of axon extension GO:0030517 IGI
    negative regulation of axon extension involved in axon guidance GO:0048843 ISO
    heart development GO:0007507 IGI
    VEGF-activated neuropilin signaling pathway GO:0038190 IMP
    negative regulation of neuron apoptotic process GO:0043524 IMP
    artery morphogenesis GO:0048844 IMP
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO
    endothelial cell chemotaxis GO:0035767 ISO
    cell migration involved in coronary vasculogenesis GO:0060980 IC
    semaphorin-plexin signaling pathway involved in neuron projection guidance GO:1902285 IMP
    regulation of axon extension involved in axon guidance GO:0048841 IDA
    nervous system development GO:0007399 IEA
    platelet-derived growth factor receptor signaling pathway GO:0048008 ISO
    positive regulation of axon extension involved in axon guidance GO:0048842 IMP
    gonadotrophin-releasing hormone neuronal migration to the hypothalamus GO:0021828 IMP
    positive chemotaxis GO:0050918 IMP
    sympathetic neuron projection guidance GO:0097491 IMP
    organ morphogenesis GO:0009887 IEA
    protein localization to early endosome GO:1902946 IMP
    toxin transport GO:1901998 IMP
    dendrite development GO:0016358 IMP
    axon guidance GO:0007411 ISO
    axonal fasciculation GO:0007413 IMP
    trigeminal ganglion development GO:0061551 IMP
    commissural neuron axon guidance GO:0071679 IMP
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IMP
    multicellular organismal development GO:0007275 IEA
    cell migration involved in sprouting angiogenesis GO:0002042 IMP
    sympathetic ganglion development GO:0061549 IMP
    motor neuron axon guidance GO:0008045 IMP
    renal artery morphogenesis GO:0061441 IMP
    trigeminal nerve structural organization GO:0021637 IMP
    facioacoustic ganglion development GO:1903375 IMP
    neuron development GO:0048666 IMP
    cellular response to vascular endothelial growth factor stimulus GO:0035924 IMP
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    sorting endosome GO:0097443 IDA
    cell surface GO:0009986 ISO
    axon GO:0030424 ISO
    extracellular space GO:0005615 ISO
    focal adhesion GO:0005925 ISO
    membrane GO:0016020 IEA
    neuronal cell body GO:0043025 ISO
    early endosome GO:0005769 IDA
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 ISO
    neurofilament GO:0005883 IDA
    growth cone GO:0030426 ISO
 Experiment description of studies that identified Nrp1 in exosomes
1
Experiment ID 214
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 215
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 216
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Nrp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Plxna1  
Affinity Capture-Western Mus musculus
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