Gene description for Pafah1b2
Gene name platelet-activating factor acetylhydrolase, isoform 1b, subunit 2
Gene symbol Pafah1b2
Other names/aliases AI747451
AU021353
Pafahb
mus[b]
Species Mus musculus
 Database cross references - Pafah1b2
ExoCarta ExoCarta_18475
Vesiclepedia VP_18475
Entrez Gene 18475
UniProt Q61206  
 Pafah1b2 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Pafah1b2
Molecular Function
    protein binding GO:0005515 IPI
    platelet-activating factor acetyltransferase activity GO:0047179 ISO
    protein homodimerization activity GO:0042803 ISO
    protein heterodimerization activity GO:0046982 ISO
    1-alkyl-2-acetylglycerophosphocholine esterase activity GO:0003847 IEA
    hydrolase activity GO:0016787 IEA
Biological Process
    lipid catabolic process GO:0016042 IEA
    movement of cell or subcellular component GO:0006928 TAS
    lipid metabolic process GO:0006629 IEA
    spermatogenesis GO:0007283 IMP
    brain development GO:0007420 IBA
    positive regulation of macroautophagy GO:0016239 ISO
Subcellular Localization
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 ISO
    extracellular exosome GO:0070062 ISO
    nucleolus GO:0005730 ISO
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Pafah1b2 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Pafah1b2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pafah1b2 is involved
No pathways found





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