Gene description for Psap
Gene name prosaposin
Gene symbol Psap
Other names/aliases AI037048
Species Mus musculus
 Database cross references - Psap
ExoCarta ExoCarta_19156
Entrez Gene 19156
UniProt Q61207  
 Psap identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Psap
Molecular Function
    G-protein coupled receptor binding GO:0001664 IPI
Biological Process
    prostate gland growth GO:0060736 IMP
    regulation of MAPK cascade GO:0043408 IMP
    sphingolipid metabolic process GO:0006665 IEA
    adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007193 IDA
    cellular response to organic substance GO:0071310 IMP
    regulation of lipid metabolic process GO:0019216 IMP
    lipid metabolic process GO:0006629 IEA
    developmental growth GO:0048589 IMP
    positive regulation of MAPK cascade GO:0043410 IDA
    negative regulation of hydrogen peroxide-induced cell death GO:1903206 IDA
    epithelial cell differentiation involved in prostate gland development GO:0060742 IMP
Subcellular Localization
    extracellular space GO:0005615 ISO
    extracellular exosome GO:0070062 ISO
    nucleoplasm GO:0005654 ISO
    extracellular region GO:0005576 IEA
    lysosome GO:0005764 IEA
    mitochondrion GO:0005739 IDA
    intracellular membrane-bounded organelle GO:0043231 ISO
    Golgi apparatus GO:0005794 ISO
    nucleolus GO:0005730 ISO
 Experiment description of studies that identified Psap in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Psap
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Psap is involved
Glycosphingolipid metabolism IEA Reactome
Peptide ligand-binding receptors IEA Reactome
Platelet degranulation IEA Reactome

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