Gene description for Ptgs1
Gene name prostaglandin-endoperoxide synthase 1
Gene symbol Ptgs1
Other names/aliases COX1
Species Mus musculus
 Database cross references - Ptgs1
ExoCarta ExoCarta_19224
Entrez Gene 19224
UniProt P22437  
 Ptgs1 identified in exosomes derived from the following tissue/cell type
Basophilic leukemia cells 20424270    
 Gene ontology annotations for Ptgs1
Molecular Function
    oxidoreductase activity GO:0016491 IEA
    prostaglandin-endoperoxide synthase activity GO:0004666 ISO
    metal ion binding GO:0046872 IEA
    peroxidase activity GO:0004601 IEA
    dioxygenase activity GO:0051213 IEA
    lipid binding GO:0008289 ISO
    heme binding GO:0020037 IEA
Biological Process
    oxidation-reduction process GO:0055114 ISO
    learning GO:0007612 ISO
    negative regulation of epinephrine secretion GO:0032811 ISO
    regulation of cell proliferation GO:0042127 IGI
    cyclooxygenase pathway GO:0019371 ISO
    positive regulation of vasoconstriction GO:0045907 ISO
    prostaglandin biosynthetic process GO:0001516 ISO
    response to oxidative stress GO:0006979 IEA
    negative regulation of norepinephrine secretion GO:0010700 ISO
    positive regulation of smooth muscle contraction GO:0045987 ISO
    maintenance of blood-brain barrier GO:0035633 ISO
    memory GO:0007613 ISO
    regulation of blood pressure GO:0008217 IMP
    prostaglandin metabolic process GO:0006693 IMP
    lipid metabolic process GO:0006629 IEA
    fatty acid biosynthetic process GO:0006633 IEA
    keratinocyte differentiation GO:0030216 NAS
    inflammatory response GO:0006954 IEA
    sensory perception of pain GO:0019233 ISO
    fatty acid metabolic process GO:0006631 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    photoreceptor outer segment GO:0001750 IDA
    extracellular exosome GO:0070062 ISO
    cytoplasm GO:0005737 ISO
    endoplasmic reticulum GO:0005783 IEA
    nuclear envelope GO:0005635 ISO
    intracellular membrane-bounded organelle GO:0043231 IEA
    membrane GO:0016020 IEA
 Experiment description of studies that identified Ptgs1 in exosomes
Experiment ID 89
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method FACS
PubMed ID 20424270    
Organism Rattus norvegicus
Experiment description Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins.
Authors Subra C, Grand D, Laulagnier K, Stella A, Lambeau G, Paillasse M, De Medina P, Monsarrat B, Perret B, Silvente-Poirot S, Poirot M, Record M.
Journal name JLR
Publication year 2010
Sample Basophilic leukemia cells
Sample name RBL-2H3
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Gas chromatography
Thin layer chromatography
Mass spectrometry [Qstar XL]
 Protein-protein interactions for Ptgs1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ptgs1 is involved
COX reactions IEA Reactome
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) IEA Reactome

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