Gene description for DNAH12
Gene name dynein, axonemal, heavy chain 12
Gene symbol DNAH12
Other names/aliases DHC3
DLP12
DNAH12L
DNAH7L
DNAHC12
DNAHC3
DNHD2
HDHC3
HL-19
HL19
Species Homo sapiens
 Database cross references - DNAH12
ExoCarta ExoCarta_201625
Entrez Gene 201625
HGNC 2943
MIM 603340
UniProt Q6ZR08  
 DNAH12 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for DNAH12
Molecular Function
    microtubule motor activity GO:0003777 IEA
    ATPase activity GO:0016887 IEA
    ATP binding GO:0005524 IEA
Biological Process
    metabolic process GO:0008152 IEA
    microtubule-based movement GO:0007018 IEA
Subcellular Localization
    cilium GO:0005929 IEA
    cytoplasm GO:0005737 IEA
    dynein complex GO:0030286 IEA
    microtubule GO:0005874 IEA
 Experiment description of studies that identified DNAH12 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for DNAH12
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which DNAH12 is involved
No pathways found





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