Gene description for S100a10
Gene name S100 calcium binding protein A10 (calpactin)
Gene symbol S100a10
Other names/aliases 42C
AA409961
AL024248
CAL12
CLP11
Cal1l
p10
p11
Species Mus musculus
 Database cross references - S100a10
ExoCarta ExoCarta_20194
Vesiclepedia VP_20194
Entrez Gene 20194
UniProt P08207  
 S100a10 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
Microglia 16081791    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for S100a10
Molecular Function
    protein homodimerization activity GO:0042803 ISO
    ion channel binding GO:0044325 ISO
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of binding GO:0051099 IMP
    establishment of protein localization to plasma membrane GO:0090002 ISO
    positive regulation of stress fiber assembly GO:0051496 ISO
    positive regulation of GTPase activity GO:0043547 ISO
    membrane raft assembly GO:0001765 ISO
    protein heterotetramerization GO:0051290 ISO
    positive regulation of substrate adhesion-dependent cell spreading GO:1900026 ISO
    positive regulation of focal adhesion assembly GO:0051894 ISO
    membrane budding GO:0006900 ISO
    cellular response to acid chemical GO:0071229 IDA
Subcellular Localization
    membrane raft GO:0045121 ISO
    extrinsic component of plasma membrane GO:0019897 IDA
    extracellular exosome GO:0070062 ISO
    endoplasmic reticulum GO:0005783 ISO
 Experiment description of studies that identified S100a10 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 14
MISEV standards
✔
EM
EV Biophysical techniques
✔
RAB7|RAB11|CD9|CD63|LAMP1|LAMP2
EV Enriched markers
✔
DNM
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 16081791    
Organism Mus musculus
Experiment description Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism.
Authors Potolicchio I, Carven GJ, Xu X, Stipp C, Riese RJ, Stern LJ, Santambrogio L
Journal name JIMMU
Publication year 2005
Sample Microglia
Sample name N9
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
3
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for S100a10
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which S100a10 is involved
PathwayEvidenceSource
Dissolution of Fibrin Clot IEA Reactome





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