Gene description for S100a10
Gene name S100 calcium binding protein A10 (calpactin)
Gene symbol S100a10
Other names/aliases 42C
AA409961
AL024248
CAL12
CLP11
Cal1l
p10
p11
Species Mus musculus
 Database cross references - S100a10
ExoCarta ExoCarta_20194
Entrez Gene 20194
UniProt P08207  
 S100a10 identified in exosomes derived from the following tissue/cell type
Microglia 16081791    
 Gene ontology annotations for S100a10
Molecular Function
    protein homodimerization activity GO:0042803 ISO
    ion channel binding GO:0044325 ISO
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of binding GO:0051099 IMP
    establishment of protein localization to plasma membrane GO:0090002 ISO
    positive regulation of stress fiber assembly GO:0051496 ISO
    positive regulation of GTPase activity GO:0043547 ISO
    membrane raft assembly GO:0001765 ISO
    protein heterotetramerization GO:0051290 ISO
    positive regulation of substrate adhesion-dependent cell spreading GO:1900026 ISO
    positive regulation of focal adhesion assembly GO:0051894 ISO
    membrane budding GO:0006900 ISO
    cellular response to acid chemical GO:0071229 IDA
Subcellular Localization
    membrane raft GO:0045121 ISO
    extrinsic component of plasma membrane GO:0019897 IDA
    extracellular exosome GO:0070062 ISO
    endoplasmic reticulum GO:0005783 ISO
 Experiment description of studies that identified S100a10 in exosomes
1
Experiment ID 14
ISEV standards
EM
EV Biophysical techniques
RAB7|RAB11
EV Cytosolic markers
CD9|CD63|LAMP1|LAMP2
EV Membrane markers
DNM
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 16081791    
Organism Mus musculus
Experiment description Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism.
Authors Potolicchio I, Carven GJ, Xu X, Stipp C, Riese RJ, Stern LJ, Santambrogio L
Journal name JIMMU
Publication year 2005
Sample Microglia
Sample name N9
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
 Protein-protein interactions for S100a10
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which S100a10 is involved
PathwayEvidenceSource
Dissolution of Fibrin Clot IEA Reactome





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