Gene description for Sftpd
Gene name surfactant associated protein D
Gene symbol Sftpd
Other names/aliases AI573415
SP-D
Sftp4
Species Mus musculus
 Database cross references - Sftpd
ExoCarta ExoCarta_20390
Entrez Gene 20390
UniProt P50404  
 Sftpd identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Sftpd
Molecular Function
    carbohydrate binding GO:0030246 IEA
    identical protein binding GO:0042802 ISO
    lipopolysaccharide binding GO:0001530 ISO
    monosaccharide binding GO:0048029 ISO
Biological Process
    respiratory gaseous exchange GO:0007585 IEA
    opsonization GO:0008228 ISO
    positive regulation of phagocytosis GO:0050766 ISO
    negative regulation of interleukin-2 production GO:0032703 ISO
    immune system process GO:0002376 IEA
    negative regulation of phagocytosis GO:0050765 ISO
    innate immune response GO:0045087 IEA
    negative regulation of T cell proliferation GO:0042130 ISO
    lung alveolus development GO:0048286 ISO
    surfactant homeostasis GO:0043129 ISO
    regulation of liquid surface tension GO:0050828 ISO
Subcellular Localization
    multivesicular body GO:0005771 ISO
    cytoplasmic vesicle GO:0031410 ISO
    extracellular space GO:0005615 ISO
    proteinaceous extracellular matrix GO:0005578 IEA
    cytoplasm GO:0005737 IDA
    collagen trimer GO:0005581 IEA
    extracellular region GO:0005576 IEA
    rough endoplasmic reticulum GO:0005791 ISO
 Experiment description of studies that identified Sftpd in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Sftpd
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Sftpd is involved
PathwayEvidenceSource
Signal regulatory protein (SIRP) family interactions IEA Reactome
Toll Like Receptor 4 (TLR4) Cascade IEA Reactome





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