Gene description for Setd1b
Gene name SET domain containing 1B
Gene symbol Setd1b
Other names/aliases AA516740
BC035291
KMT2G
mKIAA1076
Species Mus musculus
 Database cross references - Setd1b
ExoCarta ExoCarta_208043
Vesiclepedia VP_208043
Entrez Gene 208043
UniProt Q8CFT2  
 Setd1b identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Setd1b
Molecular Function
    RNA binding GO:0003723 IEA
    histone H3K4 methyltransferase activity GO:0042800 IBA
    histone H3K4 methyltransferase activity GO:0042800 ISO
    histone H3K4 monomethyltransferase activity GO:0140945 IEA
    histone H3K4 trimethyltransferase activity GO:0140999 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    methylation GO:0032259 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 ISO
    chromosome GO:0005694 IEA
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    nuclear speck GO:0016607 IEA
    histone methyltransferase complex GO:0035097 ISO
    Set1C/COMPASS complex GO:0048188 IBA
    Set1C/COMPASS complex GO:0048188 ISO
    Set1C/COMPASS complex GO:0048188 ISS
 Experiment description of studies that identified Setd1b in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Setd1b
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fitm2  
Positive Genetic Mus musculus
2 H3f3a 15078
Biochemical Activity Mus musculus
3 Setd1a  
Reconstituted Complex Mus musculus
View the network image/svg+xml



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