Gene description for Setd1b
Gene name SET domain containing 1B
Gene symbol Setd1b
Other names/aliases AA516740
BC035291
KMT2G
mKIAA1076
Species Mus musculus
 Database cross references - Setd1b
ExoCarta ExoCarta_208043
Entrez Gene 208043
UniProt Q8CFT2  
 Setd1b identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Setd1b
Molecular Function
    methyltransferase activity GO:0008168 IEA
    histone-lysine N-methyltransferase activity GO:0018024 IEA
    transferase activity GO:0016740 IEA
    nucleotide binding GO:0000166 IEA
    RNA binding GO:0003723 IEA
    nucleic acid binding GO:0003676 IEA
    molecular_function GO:0003674 ND
Biological Process
    chromatin modification GO:0016568 IEA
    methylation GO:0032259 IEA
    transcription, DNA-templated GO:0006351 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
Subcellular Localization
    chromosome GO:0005694 IEA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified Setd1b in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Setd1b
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Setd1b is involved
PathwayEvidenceSource
PKMTs methylate histone lysines IEA Reactome





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