Gene description for Hmgcs1
Gene name 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
Gene symbol Hmgcs1
Other names/aliases B130032C06Rik
Species Mus musculus
 Database cross references - Hmgcs1
ExoCarta ExoCarta_208715
Vesiclepedia VP_208715
Entrez Gene 208715
UniProt Q8JZK9  
 Hmgcs1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Hmgcs1
Molecular Function
    catalytic activity GO:0003824 IEA
    organic acid binding GO:0043177 ISO
    transferase activity GO:0016740 IEA
    isomerase activity GO:0016853 ISO
    drug binding GO:0008144 ISO
    protein homodimerization activity GO:0042803 ISO
    hydroxymethylglutaryl-CoA synthase activity GO:0004421 ISO
Biological Process
    metabolic process GO:0008152 IEA
    steroid biosynthetic process GO:0006694 IEA
    response to organonitrogen compound GO:0010243 ISO
    isoprenoid biosynthetic process GO:0008299 IEA
    sterol biosynthetic process GO:0016126 IEA
    lipid metabolic process GO:0006629 IEA
    steroid metabolic process GO:0008202 IEA
    cholesterol biosynthetic process GO:0006695 IEA
    cholesterol metabolic process GO:0008203 IEA
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    plasma membrane GO:0005886 ISO
    cytosol GO:0005829 ISO
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Hmgcs1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Hmgcs1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Hmgcs1 is involved
PathwayEvidenceSource
Cholesterol biosynthesis IEA Reactome





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