Gene description for Tgfb1
Gene name	transforming growth factor, beta 1
Gene symbol	Tgfb1
Other names/aliases	TGF-beta1 TGFbeta1 Tgfb Tgfb-1
Species	Mus musculus
Database cross references - Tgfb1
ExoCarta	ExoCarta_21803
Entrez Gene	21803
UniProt	P04202
Tgfb1 identified in exosomes derived from the following tissue/cell type
Brain cancer cells	19109410

Gene ontology annotations for Tgfb1

Molecular Function     type II transforming growth factor beta receptor binding GO:0005114 ISO     transforming growth factor beta receptor binding GO:0005160 TAS     protein binding GO:0005515 IPI     growth factor activity GO:0008083 IEA     type I transforming growth factor beta receptor binding GO:0034713 ISO     enzyme binding GO:0019899 ISO     protein homodimerization activity GO:0042803 ISO     protein heterodimerization activity GO:0046982 ISO     cytokine activity GO:0005125 IBA     protein N-terminus binding GO:0047485 ISO     glycoprotein binding GO:0001948 ISO     antigen binding GO:0003823 ISO     type III transforming growth factor beta receptor binding GO:0034714 ISO Biological Process     regulation of interleukin-23 production GO:0032667 IDA     cell growth GO:0016049 IEA     response to progesterone GO:0032570 ISO     cellular response to transforming growth factor beta stimulus GO:0071560 ISO     lymph node development GO:0048535 IMP     protein import into nucleus, translocation GO:0000060 ISO     positive regulation of cell cycle arrest GO:0071158 IDA     positive regulation of apoptotic process GO:0043065 ISO     regulation of actin cytoskeleton reorganization GO:2000249 IGI     morphogenesis of a branching structure GO:0001763 ISO     mitotic cell cycle checkpoint GO:0007093 ISO     positive regulation of SMAD protein import into nucleus GO:0060391 ISO     positive regulation of MAP kinase activity GO:0043406 ISO     positive regulation of protein localization to nucleus GO:1900182 IGI     regulation of sodium ion transport GO:0002028 IDA     negative regulation of hyaluronan biosynthetic process GO:1900126 ISO     negative regulation of transcription, DNA-templated GO:0045892 ISO     negative regulation of mitotic cell cycle GO:0045930 ISO     regulation of striated muscle tissue development GO:0016202 IDA     regulation of apoptotic process GO:0042981 IBA     hematopoietic progenitor cell differentiation GO:0002244 ISO     T-helper 17 cell lineage commitment GO:0072540 TAS     inflammatory response GO:0006954 ISO     epidermal growth factor receptor signaling pathway GO:0007173 ISO     positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO     regulation of branching involved in mammary gland duct morphogenesis GO:0060762 IGI     defense response to fungus, incompatible interaction GO:0009817 ISO     negative regulation of release of sequestered calcium ion into cytosol GO:0051280 ISO     cellular response to dexamethasone stimulus GO:0071549 ISO     defense response GO:0006952 TAS     positive regulation of fibroblast proliferation GO:0048146 IDA     SMAD protein import into nucleus GO:0007184 ISO     positive regulation of cell migration GO:0030335 ISO     cell development GO:0048468 IBA     positive regulation of superoxide anion generation GO:0032930 ISO     positive regulation of smooth muscle cell differentiation GO:0051152 ISO     CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment GO:0002362 TAS     positive regulation of odontogenesis GO:0042482 IDA     negative regulation of blood vessel endothelial cell migration GO:0043537 ISO     cell-cell junction organization GO:0045216 ISO     chondrocyte differentiation GO:0002062 ISO     positive regulation of peptidyl-threonine phosphorylation GO:0010800 ISO     germ cell migration GO:0008354 IDA     positive regulation of NF-kappaB transcription factor activity GO:0051092 ISO     hyaluronan catabolic process GO:0030214 ISO     negative regulation of gene expression GO:0010629 ISO     negative regulation of gene silencing by miRNA GO:0060965 ISO     positive regulation of exit from mitosis GO:0031536 ISO     endoderm development GO:0007492 IDA     positive regulation of protein complex assembly GO:0031334 ISO     negative regulation of epithelial cell proliferation GO:0050680 ISO     cell proliferation GO:0008283 TAS     positive regulation of cell division GO:0051781 IEA     T cell activation GO:0042110 IMP     receptor catabolic process GO:0032801 ISO     positive regulation of chemotaxis GO:0050921 ISO     regulation of protein import into nucleus GO:0042306 IDA     wound healing GO:0042060 ISO     response to cholesterol GO:0070723 ISO     ATP biosynthetic process GO:0006754 ISO     regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation GO:0032829 TAS     positive regulation of epithelial to mesenchymal transition GO:0010718 ISO     negative regulation of T cell proliferation GO:0042130 IMP     positive regulation of gene expression GO:0010628 ISO     lens fiber cell differentiation GO:0070306 IMP     regulation of transforming growth factor beta receptor signaling pathway GO:0017015 ISO     positive regulation of protein dephosphorylation GO:0035307 ISO     positive regulation of cellular protein metabolic process GO:0032270 ISO     negative regulation of ossification GO:0030279 IDA     regulation of gene expression GO:0010468 IDA     cellular response to growth factor stimulus GO:0071363 IDA     positive regulation of fibroblast migration GO:0010763 ISO     negative regulation of interleukin-17 production GO:0032700 IDA     protein phosphorylation GO:0006468 ISO     negative regulation of fat cell differentiation GO:0045599 ISO     positive regulation of protein import into nucleus GO:0042307 ISO     negative regulation of skeletal muscle tissue development GO:0048642 ISO     positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 ISO     skeletal system development GO:0001501 TAS     regulation of binding GO:0051098 IDA     growth GO:0040007 IEA     positive regulation of isotype switching to IgA isotypes GO:0048298 ISO     positive regulation of histone acetylation GO:0035066 IDA     mammary gland development GO:0030879 IDA     negative regulation of macrophage cytokine production GO:0010936 ISO     regulatory T cell differentiation GO:0045066 IMP     common-partner SMAD protein phosphorylation GO:0007182 ISO     regulation of cartilage development GO:0061035 IDA     mononuclear cell proliferation GO:0032943 IMP     cell cycle arrest GO:0007050 ISO     transforming growth factor beta receptor signaling pathway GO:0007179 ISO     positive regulation of transcription, DNA-templated GO:0045893 ISO     positive regulation of protein kinase B signaling GO:0051897 ISO     positive regulation of collagen biosynthetic process GO:0032967 ISO     protein kinase B signaling GO:0043491 ISO     negative regulation of immune response GO:0050777 ISO     negative regulation of cell growth GO:0030308 ISO     positive regulation of NAD+ ADP-ribosyltransferase activity GO:1901666 ISO     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IGI     positive regulation of peptidyl-serine phosphorylation GO:0033138 ISO     organ morphogenesis GO:0009887 TAS     evasion or tolerance of host defenses by virus GO:0019049 ISO     negative regulation of cell cycle GO:0045786 ISO     positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 ISO     extracellular matrix assembly GO:0085029 ISO     T cell differentiation GO:0030217 IMP     negative regulation of neuroblast proliferation GO:0007406 ISO     SMAD protein signal transduction GO:0060395 IBA     tolerance induction to self antigen GO:0002513 IMP     pathway-restricted SMAD protein phosphorylation GO:0060389 ISO     negative regulation of cell proliferation GO:0008285 TAS     positive regulation of transcription regulatory region DNA binding GO:2000679 ISO     cellular response to organic cyclic compound GO:0071407 ISO     negative regulation of cell-cell adhesion GO:0022408 ISO     response to organic substance GO:0010033 ISO     myelination GO:0042552 ISO     branch elongation involved in mammary gland duct branching GO:0060751 IMP     Notch signaling pathway GO:0007219 IDA     regulation of DNA binding GO:0051101 IDA     protein export from nucleus GO:0006611 ISO     positive regulation of protein phosphorylation GO:0001934 ISO     phosphate-containing compound metabolic process GO:0006796 ISO     positive regulation of blood vessel endothelial cell migration GO:0043536 ISO     myeloid dendritic cell differentiation GO:0043011 IMP     extrinsic apoptotic signaling pathway GO:0097191 ISO     organ regeneration GO:0031100 ISO     positive regulation of interleukin-17 production GO:0032740 ISO     negative regulation of T cell activation GO:0050868 IMP     positive regulation of histone deacetylation GO:0031065 IDA     positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 ISO     positive regulation of epithelial cell proliferation GO:0050679 ISO     lipopolysaccharide-mediated signaling pathway GO:0031663 ISO     skeletal muscle tissue development GO:0007519 TAS     T cell homeostasis GO:0043029 IMP     mammary gland branching involved in thelarche GO:0060744 IMP     response to estradiol GO:0032355 ISO     positive regulation of protein secretion GO:0050714 ISO     regulation of MAPK cascade GO:0043408 IBA     negative regulation of DNA replication GO:0008156 ISO     SMAD protein complex assembly GO:0007183 ISO     regulation of cell proliferation GO:0042127 IDA     MAPK cascade GO:0000165 ISO     positive regulation of cell proliferation GO:0008284 ISO     cellular calcium ion homeostasis GO:0006874 IMP     negative regulation of protein phosphorylation GO:0001933 ISO     epithelial to mesenchymal transition GO:0001837 ISO     cell activation GO:0001775 IDA     adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 IDA     negative regulation of phagocytosis GO:0050765 ISO     negative regulation of myoblast differentiation GO:0045662 ISO Subcellular Localization     blood microparticle GO:0072562 ISO     microvillus GO:0005902 ISO     neuronal cell body GO:0043025 ISO     cell surface GO:0009986 ISO     proteinaceous extracellular matrix GO:0005578 IDA     cell GO:0005623 IMP     secretory granule GO:0030141 ISO     extracellular space GO:0005615 ISO     cytoplasm GO:0005737 ISO     extracellular region GO:0005576 IEA     axon GO:0030424 ISO     nucleus GO:0005634 ISO