Gene description for Col1a1
Gene name collagen, type I, alpha 1
Gene symbol Col1a1
Other names/aliases Col1a-1
Cola-1
Cola1
Mov-13
Mov13
Species Mus musculus
 Database cross references - Col1a1
ExoCarta ExoCarta_12842
Vesiclepedia VP_12842
Entrez Gene 12842
UniProt P11087  
 Col1a1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
Embryonic fibroblasts 18494037    
Fibroblasts 23260141    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Col1a1
Molecular Function
    identical protein binding GO:0042802 ISO
    platelet-derived growth factor binding GO:0048407 ISO
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    extracellular matrix structural constituent GO:0005201 IDA
Biological Process
    intramembranous ossification GO:0001957 IGI
    face morphogenesis GO:0060325 IGI
    tooth mineralization GO:0034505 ISO
    positive regulation of transcription, DNA-templated GO:0045893 ISO
    skin development GO:0043588 IMP
    collagen fibril organization GO:0030199 ISO
    cartilage development involved in endochondral bone morphogenesis GO:0060351 IMP
    wound healing GO:0042060 ISO
    positive regulation of cell migration GO:0030335 ISO
    blood vessel development GO:0001568 ISO
    visual perception GO:0007601 ISO
    protein transport GO:0015031 IMP
    collagen biosynthetic process GO:0032964 ISO
    positive regulation of canonical Wnt signaling pathway GO:0090263 ISO
    positive regulation of epithelial to mesenchymal transition GO:0010718 ISO
    cellular response to amino acid stimulus GO:0071230 IDA
    bone trabecula formation GO:0060346 IGI
    protein heterotrimerization GO:0070208 IDA
    skin morphogenesis GO:0043589 ISO
    sensory perception of sound GO:0007605 ISO
    skeletal system development GO:0001501 ISO
    embryonic skeletal system development GO:0048706 ISO
    negative regulation of cell-substrate adhesion GO:0010812 IDA
    protein localization to nucleus GO:0034504 ISO
    skeletal system morphogenesis GO:0048705 IGI
    endochondral ossification GO:0001958 IMP
Subcellular Localization
    endoplasmic reticulum GO:0005783 ISO
    collagen type I trimer GO:0005584 ISO
    Golgi apparatus GO:0005794 ISO
    extracellular matrix GO:0031012 ISO
    collagen trimer GO:0005581 IMP
    extracellular space GO:0005615 ISO
    secretory granule GO:0030141 ISO
    proteinaceous extracellular matrix GO:0005578 IDA
    extracellular region GO:0005576 IEA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified Col1a1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 73
MISEV standards
✔
EM
EV Biophysical techniques
✔
HSP70|HSP90
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 18494037    
Organism Mus musculus
Experiment description Difference gel electrophoresis analysis of Ras-transformed fibroblast cell-derived exosomes.
Authors Ji H, Erfani N, Tauro BJ, Kapp EA, Zhu HJ, Moritz RL, Lim JW, Simpson RJ
Journal name ELEC
Publication year 2008
Sample Embryonic fibroblasts
Sample name NIH3T3
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA]
Western blotting
3
Experiment ID 210
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD81|FLOT1
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Col1a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here