Gene description for Serpinf1
Gene name serine (or cysteine) peptidase inhibitor, clade F, member 1
Gene symbol Serpinf1
Other names/aliases AI195227
Species Mus musculus
 Database cross references - Serpinf1
ExoCarta ExoCarta_20317
Entrez Gene 20317
UniProt P97298  
 Serpinf1 identified in exosomes derived from the following tissue/cell type
Mov neuroglial cells 15210972    
 Gene ontology annotations for Serpinf1
Molecular Function
    serine-type endopeptidase inhibitor activity GO:0004867 IBA
Biological Process
    negative regulation of epithelial cell proliferation involved in prostate gland development GO:0060770 IMP
    negative regulation of gene expression GO:0010629 ISO
    positive regulation of neuron projection development GO:0010976 ISO
    negative regulation of inflammatory response GO:0050728 ISO
    negative regulation of neuron death GO:1901215 ISO
    negative regulation of angiogenesis GO:0016525 ISO
    negative regulation of endopeptidase activity GO:0010951 IBA
    short-term memory GO:0007614 ISO
    negative regulation of endothelial cell migration GO:0010596 ISO
    positive regulation of neurogenesis GO:0050769 ISO
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    extracellular matrix GO:0031012 ISO
    extracellular region GO:0005576 ISO
    axon GO:0030424 ISO
    neuronal cell body GO:0043025 ISO
    extracellular space GO:0005615 ISO
    axon hillock GO:0043203 ISO
    basement membrane GO:0005604 ISO
 Experiment description of studies that identified Serpinf1 in exosomes
Experiment ID 39
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15210972    
Organism Mus musculus
Experiment description Cells release prions in association with exosomes.
Authors Fevrier B, Vilette D, Archer F, Loew D, Faigle W, Vidal M, Laude H, Raposo G
Journal name PNAS
Publication year 2004
Sample Mov neuroglial cells
Sample name Mov neuroglial cell
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Serpinf1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Serpinf1 is involved
No pathways found

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