Gene description for Tnc
Gene name tenascin C
Gene symbol Tnc
Other names/aliases AI528729
Species Mus musculus
 Database cross references - Tnc
ExoCarta ExoCarta_21923
Entrez Gene 21923
UniProt Q80YX1  
 Tnc identified in exosomes derived from the following tissue/cell type
Mov neuroglial cells 15210972    
 Gene ontology annotations for Tnc
Molecular Function
    fibronectin binding GO:0001968 ISO
    syndecan binding GO:0045545 ISO
Biological Process
    negative regulation of cell adhesion GO:0007162 ISO
    positive regulation of cell proliferation GO:0008284 IDA
    osteoblast differentiation GO:0001649 ISO
    peripheral nervous system axon regeneration GO:0014012 IMP
    cell adhesion GO:0007155 IEA
    neuromuscular junction development GO:0007528 IMP
    positive regulation of gene expression GO:0010628 IDA
    mesenchymal-epithelial cell signaling involved in prostate gland development GO:0060739 IMP
    prostate gland epithelium morphogenesis GO:0060740 IMP
    neuron projection development GO:0031175 ISO
    bud outgrowth involved in lung branching GO:0060447 ISO
Subcellular Localization
    extracellular matrix GO:0031012 ISO
    proteinaceous extracellular matrix GO:0005578 ISO
    extracellular space GO:0005615 ISO
    basement membrane GO:0005604 IDA
    extracellular region GO:0005576 IDA
    membrane GO:0016020 ISO
    interstitial matrix GO:0005614 IDA
    focal adhesion GO:0005925 ISO
 Experiment description of studies that identified Tnc in exosomes
Experiment ID 39
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15210972    
Organism Mus musculus
Experiment description Cells release prions in association with exosomes.
Authors Fevrier B, Vilette D, Archer F, Loew D, Faigle W, Vidal M, Laude H, Raposo G
Journal name PNAS
Publication year 2004
Sample Mov neuroglial cells
Sample name Mov neuroglial cell
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Tnc
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tnc is involved
ECM proteoglycans IEA Reactome
Integrin cell surface interactions IEA Reactome
Syndecan interactions IEA Reactome

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