Gene description for Ube2l3
Gene name ubiquitin-conjugating enzyme E2L 3
Gene symbol Ube2l3
Other names/aliases C79827
Species Mus musculus
 Database cross references - Ube2l3
ExoCarta ExoCarta_22195
Entrez Gene 22195
UniProt P68037  
 Ube2l3 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ube2l3
Molecular Function
    poly(A) RNA binding GO:0044822 ISO
    transcription coactivator activity GO:0003713 ISO
    ubiquitin conjugating enzyme activity GO:0061631 ISO
    ubiquitin protein ligase binding GO:0031625 ISO
    ubiquitin-protein transferase activator activity GO:0097027 ISO
    ubiquitin-protein transferase activity GO:0004842 ISO
Biological Process
    protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042787 IMP
    cell cycle phase transition GO:0044770 ISO
    protein ubiquitination GO:0016567 ISO
    cellular response to steroid hormone stimulus GO:0071383 ISO
    positive regulation of protein targeting to mitochondrion GO:1903955 ISO
    protein K11-linked ubiquitination GO:0070979 ISO
    protein polyubiquitination GO:0000209 ISO
    cellular response to glucocorticoid stimulus GO:0071385 ISO
    cell proliferation GO:0008283 ISO
    positive regulation of protein ubiquitination GO:0031398 ISO
    regulation of transcription, DNA-templated GO:0006355 ISO
    positive regulation of ubiquitin-protein transferase activity GO:0051443 ISO
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    cytoplasm GO:0005737 ISO
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Ube2l3 in exosomes
Experiment ID 15
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
 Protein-protein interactions for Ube2l3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBOX5  
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which Ube2l3 is involved
No pathways found

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