Gene description for Lppr4
Gene name lipid phosphate phosphatase-related protein type 4
Gene symbol Lppr4
Other names/aliases A330086D10
D3Bwg0562e
PRG-1
mKIAA0455
Species Mus musculus
 Database cross references - Lppr4
ExoCarta ExoCarta_229791
Vesiclepedia VP_229791
Entrez Gene 229791
UniProt Q7TME0  
 Lppr4 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Lppr4
Molecular Function
    protein binding GO:0005515 IPI
    phosphatidate phosphatase activity GO:0008195 IBA
    lipid phosphatase activity GO:0042577 ISO
    lysophosphatidic acid phosphatase activity GO:0052642 ISO
    lysophosphatidic acid phosphatase activity GO:0052642 ISS
Biological Process
    phospholipid metabolic process GO:0006644 IBA
    phospholipid metabolic process GO:0006644 IEA
    signal transduction GO:0007165 IBA
    G protein-coupled receptor signaling pathway GO:0007186 IMP
    axonogenesis GO:0007409 IBA
    axonogenesis GO:0007409 ISO
    phospholipid dephosphorylation GO:0046839 IBA
    phospholipid dephosphorylation GO:0046839 ISO
    phospholipid dephosphorylation GO:0046839 ISS
    inner ear development GO:0048839 IDA
    modulation of chemical synaptic transmission GO:0050804 IDA
    modulation of chemical synaptic transmission GO:0050804 IMP
    regulation of synaptic transmission, glutamatergic GO:0051966 IMP
    regulation of postsynapse organization GO:0099175 IDA
    regulation of postsynapse organization GO:0099175 IMP
    lipid import into cell GO:0140354 IMP
Subcellular Localization
    plasma membrane GO:0005886 IBA
    external side of plasma membrane GO:0009897 ISO
    Schaffer collateral - CA1 synapse GO:0098685 IDA
    Schaffer collateral - CA1 synapse GO:0098685 IMP
    postsynaptic density membrane GO:0098839 IDA
    postsynaptic density membrane GO:0098839 IDA
    postsynaptic density membrane GO:0098839 IEP
    postsynaptic density membrane GO:0098839 ISO
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IEP
    glutamatergic synapse GO:0098978 IMP
 Experiment description of studies that identified Lppr4 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Lppr4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fmr1  
Affinity Capture-MS Mus musculus
2 Sstr3  
Proximity Label-MS Mus musculus
3 Prkcsh 19089
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
4 Kctd13  
Affinity Capture-MS Mus musculus
5 Trim67  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
View the network image/svg+xml



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