Gene description for Zcchc11
Gene name zinc finger, CCHC domain containing 11
Gene symbol Zcchc11
Other names/aliases 6030404K05Rik
9230115F04Rik
PPAPD3
mKIAA0191
Species Mus musculus
 Database cross references - Zcchc11
ExoCarta ExoCarta_230594
Entrez Gene 230594
UniProt B2RX14  
 Zcchc11 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Zcchc11
Molecular Function
    transferase activity GO:0016740 IEA
    RNA uridylyltransferase activity GO:0050265 ISO
    zinc ion binding GO:0008270 IEA
    protein binding GO:0005515 IPI
    nucleotidyltransferase activity GO:0016779 IEA
    metal ion binding GO:0046872 IEA
    poly(A) RNA binding GO:0044822 ISO
    nucleic acid binding GO:0003676 IEA
Biological Process
    cytokine production GO:0001816 IDA
    negative regulation of NF-kappaB transcription factor activity GO:0032088 IDA
    regulation of lipopolysaccharide-mediated signaling pathway GO:0031664 IDA
    miRNA catabolic process GO:0010587 ISO
    RNA 3'-end processing GO:0031123 ISO
    stem cell maintenance GO:0019827 ISO
    positive regulation of interleukin-6 production GO:0032755 IMP
    pre-miRNA processing GO:0031054 ISO
    gene silencing by RNA GO:0031047 IEA
    miRNA metabolic process GO:0010586 IMP
    interleukin-6-mediated signaling pathway GO:0070102 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 ISO
    extracellular space GO:0005615 ISO
    nucleolus GO:0005730 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Zcchc11 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Zcchc11
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Zcchc11 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here