Gene description for Zcchc11
Gene name zinc finger, CCHC domain containing 11
Gene symbol Zcchc11
Other names/aliases 6030404K05Rik
9230115F04Rik
PPAPD3
mKIAA0191
Species Mus musculus
 Database cross references - Zcchc11
ExoCarta ExoCarta_230594
Vesiclepedia VP_230594
Entrez Gene 230594
UniProt B2RX14  
 Zcchc11 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Zcchc11
Molecular Function
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    miRNA binding GO:0035198 IDA
    RNA uridylyltransferase activity GO:0050265 IBA
    RNA uridylyltransferase activity GO:0050265 IDA
    RNA uridylyltransferase activity GO:0050265 ISO
    RNA uridylyltransferase activity GO:0050265 TAS
    uridylyltransferase activity GO:0070569 IDA
    uridylyltransferase activity GO:0070569 IMP
Biological Process
    oocyte maturation GO:0001556 IMP
    cytokine production GO:0001816 IDA
    miRNA metabolic process GO:0010586 IMP
    miRNA metabolic process GO:0010586 ISO
    miRNA metabolic process GO:0010586 ISS
    miRNA catabolic process GO:0010587 ISO
    miRNA catabolic process GO:0010587 ISS
    stem cell population maintenance GO:0019827 ISO
    stem cell population maintenance GO:0019827 ISS
    pre-miRNA processing GO:0031054 ISO
    pre-miRNA processing GO:0031054 ISS
    RNA 3'-end processing GO:0031123 IDA
    RNA 3'-end processing GO:0031123 ISO
    regulation of lipopolysaccharide-mediated signaling pathway GO:0031664 IDA
    negative regulation of NF-kappaB transcription factor activity GO:0032088 IDA
    positive regulation of interleukin-6 production GO:0032755 IMP
    interleukin-6-mediated signaling pathway GO:0070102 IMP
    histone mRNA catabolic process GO:0071044 ISS
    RNA 3' uridylation GO:0071076 IBA
    RNA 3' uridylation GO:0071076 IDA
    RNA 3' uridylation GO:0071076 IMP
    transposable element silencing by mRNA destabilization GO:0141008 ISO
    transposable element silencing by mRNA destabilization GO:0141008 ISS
    polyuridylation-dependent mRNA catabolic process GO:1990074 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleolus GO:0005730 ISO
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 ISO
    cytosol GO:0005829 TAS
    cytoplasmic ribonucleoprotein granule GO:0036464 ISO
    cytoplasmic ribonucleoprotein granule GO:0036464 ISS
 Experiment description of studies that identified Zcchc11 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Zcchc11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Iqce  
Co-fractionation Mus musculus
2 Tmem173  
Proximity Label-MS Mus musculus
3 Nlrx1  
Co-fractionation Mus musculus
4 Xylt1 233781
Co-fractionation Mus musculus
5 Pou5f1  
Affinity Capture-MS Mus musculus
6 Aspm  
Co-fractionation Mus musculus
7 Rin3  
Co-fractionation Mus musculus
8 Speg  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Zcchc11 is involved
No pathways found





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