Gene description for Xylt1
Gene name xylosyltransferase 1
Gene symbol Xylt1
Other names/aliases 8030490L12
Species Mus musculus
 Database cross references - Xylt1
ExoCarta ExoCarta_233781
Vesiclepedia VP_233781
Entrez Gene 233781
UniProt Q811B1  
 Xylt1 identified in sEVs derived from the following tissue/cell type
Melanoma cells 34957415    
Melanoma cells 34957415    
 Gene ontology annotations for Xylt1
Molecular Function
    protein xylosyltransferase activity GO:0030158 IBA
    protein xylosyltransferase activity GO:0030158 IDA
    protein xylosyltransferase activity GO:0030158 IMP
    protein xylosyltransferase activity GO:0030158 ISO
    protein xylosyltransferase activity GO:0030158 ISS
    metal ion binding GO:0046872 IEA
Biological Process
    glycosaminoglycan biosynthetic process GO:0006024 IMP
    heparan sulfate proteoglycan biosynthetic process GO:0015012 IBA
    heparan sulfate proteoglycan biosynthetic process GO:0015012 IEA
    heparan sulfate proteoglycan biosynthetic process GO:0015012 ISO
    heparan sulfate proteoglycan biosynthetic process GO:0015012 ISS
    proteoglycan biosynthetic process GO:0030166 ISO
    proteoglycan biosynthetic process GO:0030166 ISS
    chondroitin sulfate biosynthetic process GO:0030206 IEA
    chondroitin sulfate biosynthetic process GO:0030206 IMP
    cellular response to heat GO:0034605 IDA
    ossification involved in bone maturation GO:0043931 IMP
    negative regulation of axon regeneration GO:0048681 ISO
    embryonic skeletal system development GO:0048706 IMP
    chondroitin sulfate proteoglycan biosynthetic process GO:0050650 IBA
    chondroitin sulfate proteoglycan biosynthetic process GO:0050650 ISO
    chondroitin sulfate proteoglycan biosynthetic process GO:0050650 ISS
Subcellular Localization
    Golgi cis cisterna GO:0000137 IDA
    Golgi membrane GO:0000139 ISO
    Golgi membrane GO:0000139 ISS
    extracellular space GO:0005615 ISO
    extracellular space GO:0005615 ISS
    Golgi apparatus GO:0005794 IDA
    Golgi apparatus GO:0005794 ISO
 Experiment description of studies that identified Xylt1 in sEVs
1
Experiment ID 1117
MISEV standards
Biophysical techniques
Cd81|Icam1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 1118
MISEV standards
Biophysical techniques
Cd81|Icam1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Xylt1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Aspm  
Co-fractionation Mus musculus
2 Xylt2 217119
Co-fractionation Mus musculus
3 Zcchc11 230594
Co-fractionation Mus musculus
4 Rin3  
Co-fractionation Mus musculus
5 Speg  
Co-fractionation Mus musculus
View the network image/svg+xml



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