Gene description for Nrd1
Gene name nardilysin, N-arginine dibasic convertase, NRD convertase 1
Gene symbol Nrd1
Other names/aliases 2600011I06Rik
Species Mus musculus
 Database cross references - Nrd1
ExoCarta ExoCarta_230598
Entrez Gene 230598
UniProt Q8BHG1  
 Nrd1 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Nrd1
Molecular Function
    peptidase activity GO:0008233 ISO
    metallopeptidase activity GO:0008237 IEA
    catalytic activity GO:0003824 IEA
    protein binding GO:0005515 IPI
    hydrolase activity GO:0016787 IEA
    metal ion binding GO:0046872 IEA
    metalloendopeptidase activity GO:0004222 IEA
Biological Process
    regulation of endopeptidase activity GO:0052548 ISO
    positive regulation of membrane protein ectodomain proteolysis GO:0051044 ISO
    proteolysis GO:0006508 ISO
Subcellular Localization
    mitochondrion GO:0005739 IDA
 Experiment description of studies that identified Nrd1 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Nrd1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Nrd1 is involved
No pathways found

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