Gene description for Tsn
Gene name translin
Gene symbol Tsn
Other names/aliases 2610034C24Rik
AU040286
C3PO
TB-RBP
Species Mus musculus
 Database cross references - Tsn
ExoCarta ExoCarta_22099
Vesiclepedia VP_22099
Entrez Gene 22099
UniProt Q62348  
 Tsn identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
Pancreatic cells 19351151    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Tsn
Molecular Function
    T/G mismatch-specific endonuclease activity GO:0043765 IEA
    protein complex binding GO:0032403 ISO
    retroviral 3' processing activity GO:0044824 IEA
    endoribonuclease activity GO:0004521 IBA
    RNA binding GO:0003723 IDA
    single-stranded DNA binding GO:0003697 ISO
    endonuclease activity GO:0004519 IEA
    protein binding GO:0005515 IPI
    mRNA binding GO:0003729 IDA
    phosphoric ester hydrolase activity GO:0042578 IEA
    sequence-specific DNA binding GO:0043565 ISO
    hydrolase activity GO:0016787 IEA
    DNA binding GO:0003677 IEA
    nuclease activity GO:0004518 IEA
Biological Process
    RNA phosphodiester bond hydrolysis, endonucleolytic GO:0090502 IBA
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 TAS
 Experiment description of studies that identified Tsn in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 188
MISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH|UCHL1|HSP90
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Tsn
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TSNAX 7257
Reconstituted Complex Homo sapiens
2 Tsnax  
Two-hybrid Mus musculus
View the network image/svg+xml
 Pathways in which Tsn is involved
PathwayEvidenceSource
Small interfering RNA (siRNA) biogenesis IEA Reactome





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