Gene description for DDN
Gene name dendrin
Gene symbol DDN
Other names/aliases -
Species Homo sapiens
 Database cross references - DDN
ExoCarta ExoCarta_23109
Entrez Gene 23109
HGNC 24458
MIM 610588
UniProt O94850  
 DDN identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for DDN
Molecular Function
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IEA
    protein binding GO:0005515 IPI
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity GO:0000982 IEA
Biological Process
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA
    transcription from RNA polymerase II promoter GO:0006366 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    perikaryon GO:0043204 IEA
    cytoplasm GO:0005737 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    cell projection GO:0042995 IDA
    dendritic spine membrane GO:0032591 IEA
 Experiment description of studies that identified DDN in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for DDN
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which DDN is involved
No pathways found





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