Gene description for Ap2s1
Gene name adaptor-related protein complex 2, sigma 1 subunit
Gene symbol Ap2s1
Other names/aliases AI043088
Species Mus musculus
 Database cross references - Ap2s1
ExoCarta ExoCarta_232910
Entrez Gene 232910
UniProt P62743  
 Ap2s1 identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Ap2s1
Molecular Function
    protein transporter activity GO:0008565 IEA
    molecular_function GO:0003674 ND
Biological Process
    intracellular protein transport GO:0006886 IEA
    transport GO:0006810 IEA
    protein transport GO:0015031 IEA
    endocytosis GO:0006897 IEA
    vesicle-mediated transport GO:0016192 IEA
Subcellular Localization
    AP-2 adaptor complex GO:0030122 ISO
    membrane coat GO:0030117 IEA
    membrane GO:0016020 IEA
    coated pit GO:0005905 IEA
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified Ap2s1 in exosomes
1
Experiment ID 264
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th2 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ap2s1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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