Gene description for Atxn2l
Gene name ataxin 2-like
Gene symbol Atxn2l
Other names/aliases A2D
A2LG
A2RP
A2lp
Atxnl2
Species Mus musculus
 Database cross references - Atxn2l
ExoCarta ExoCarta_233871
Vesiclepedia VP_233871
Entrez Gene 233871
UniProt Q7TQH0  
 Atxn2l identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Atxn2l
Molecular Function
    RNA binding GO:0003723 IEA
    mRNA binding GO:0003729 IBA
Biological Process
    mRNA metabolic process GO:0016071 ISO
    stress granule assembly GO:0034063 IBA
Subcellular Localization
    cytosol GO:0005829 ISO
    cytoplasmic stress granule GO:0010494 IBA
    cytoplasmic stress granule GO:0010494 ISO
    cytoplasmic stress granule GO:0010494 ISS
    membrane GO:0016020 ISO
    nuclear speck GO:0016607 ISO
    nuclear speck GO:0016607 ISS
 Experiment description of studies that identified Atxn2l in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Atxn2l
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Zbtb7b  
Affinity Capture-MS Mus musculus
2 Tmem173  
Proximity Label-MS Mus musculus
3 Atxn1  
Affinity Capture-MS Mus musculus
4 Kctd13  
Affinity Capture-MS Mus musculus
5 MKRN1 23608
Affinity Capture-MS Homo sapiens
6 Eif4e  
Co-fractionation Mus musculus
7 Rptor  
Co-fractionation Mus musculus
8 Gigyf2  
Co-fractionation Mus musculus
9 Nanog  
Affinity Capture-MS Mus musculus
10 Fancd2  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Atxn2l is involved
No pathways found





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