Gene description for Dnajb6
Gene name DnaJ (Hsp40) homolog, subfamily B, member 6
Gene symbol Dnajb6
Other names/aliases Mrj
mDj4
Species Mus musculus
 Database cross references - Dnajb6
ExoCarta ExoCarta_23950
Entrez Gene 23950
UniProt O54946  
 Dnajb6 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Dnajb6
Molecular Function
    ATPase activator activity GO:0001671 ISO
    protein binding GO:0005515 IPI
    heat shock protein binding GO:0031072 ISO
    chaperone binding GO:0051087 ISO
    protein binding involved in protein folding GO:0044183 ISO
    unfolded protein binding GO:0051082 ISO
    DNA binding GO:0003677 IDA
Biological Process
    negative regulation of inclusion body assembly GO:0090084 ISO
    protein folding GO:0006457 ISO
    intermediate filament organization GO:0045109 ISO
    positive regulation of ATPase activity GO:0032781 ISO
    syncytiotrophoblast cell differentiation involved in labyrinthine layer development GO:0060715 IMP
    protein localization to nucleus GO:0034504 IMP
    chorio-allantoic fusion GO:0060710 IMP
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 ISO
    extracellular matrix organization GO:0030198 IMP
    chaperone-mediated protein folding GO:0061077 ISO
    chorion development GO:0060717 IMP
    actin cytoskeleton organization GO:0030036 IMP
    negative regulation of transcription, DNA-templated GO:0045892 IDA
Subcellular Localization
    membrane GO:0016020 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    Z disc GO:0030018 ISO
    nucleus GO:0005634 ISO
    cytosol GO:0005829 ISO
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Dnajb6 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Dnajb6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Dnajb6 is involved
PathwayEvidenceSource
Regulation of HSF1-mediated heat shock response IEA Reactome





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