Gene description for Gstm1
Gene name glutathione S-transferase mu 1
Gene symbol Gstm1
Other names/aliases GSTA3
Species Rattus norvegicus
 Database cross references - Gstm1
ExoCarta ExoCarta_24423
Vesiclepedia VP_24423
Entrez Gene 24423
UniProt P04905  
 Gstm1 identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Gstm1
Molecular Function
    glutathione transferase activity GO:0004364 IBA
    glutathione transferase activity GO:0004364 IDA
    glutathione transferase activity GO:0004364 IEA
    glutathione transferase activity GO:0004364 ISO
    steroid binding GO:0005496 IPI
    nickel cation binding GO:0016151 IDA
    enzyme binding GO:0019899 ISO
    protein kinase binding GO:0019901 IPI
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 IPI
    identical protein binding GO:0042802 ISO
    protein homodimerization activity GO:0042803 ISO
    glutathione binding GO:0043295 IDA
    glutathione binding GO:0043295 ISO
Biological Process
    prostaglandin metabolic process GO:0006693 ISO
    prostaglandin metabolic process GO:0006693 ISS
    glutathione metabolic process GO:0006749 IBA
    glutathione metabolic process GO:0006749 IDA
    glutathione metabolic process GO:0006749 IMP
    glutathione metabolic process GO:0006749 ISO
    sensory perception of smell GO:0007608 IEA
    response to xenobiotic stimulus GO:0009410 IEP
    response to metal ion GO:0010038 IEP
    response to lead ion GO:0010288 IEP
    nitrobenzene metabolic process GO:0018916 ISO
    xenobiotic catabolic process GO:0042178 IDA
    xenobiotic catabolic process GO:0042178 ISO
    response to amino acid GO:0043200 IEP
    response to ethanol GO:0045471 IEP
    response to axon injury GO:0048678 IEP
    hepoxilin biosynthetic process GO:0051122 ISO
    hepoxilin biosynthetic process GO:0051122 ISS
    cellular detoxification of nitrogen compound GO:0070458 ISO
    cellular response to xenobiotic stimulus GO:0071466 ISO
    glutathione derivative biosynthetic process GO:1901687 ISO
    glutathione derivative biosynthetic process GO:1901687 ISS
Subcellular Localization
    extracellular region GO:0005576 IDA
    cytoplasm GO:0005737 IEA
    cytoplasm GO:0005737 ISO
    mitochondrion GO:0005739 ISO
    cytosol GO:0005829 IDA
    cytosol GO:0005829 ISO
    protein-containing complex GO:0032991 IDA
    intercellular bridge GO:0045171 ISO
 Experiment description of studies that identified Gstm1 in sEVs
1
Experiment ID 35
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|CD81|CD63
Enriched markers
HSPA5
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Gstm1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Mib1  
Affinity Capture-MS Rattus norvegicus
2 Gstm1 24423
Co-crystal Structure Rattus norvegicus
Co-crystal Structure Rattus norvegicus
View the network image/svg+xml
 Pathways in which Gstm1 is involved
PathwayEvidenceSource
Biological oxidations IEA Reactome
Glutathione conjugation IEA Reactome
Metabolism IEA Reactome
Phase II - Conjugation of compounds IEA Reactome





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