Gene description for Nrp1
Gene name neuropilin 1
Gene symbol Nrp1
Other names/aliases Nrp
Species Rattus norvegicus
 Database cross references - Nrp1
ExoCarta ExoCarta_246331
Entrez Gene 246331
UniProt Q9QWJ9  
 Nrp1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Nrp1
Molecular Function
    vascular endothelial growth factor-activated receptor activity GO:0005021 ISO
    metal ion binding GO:0046872 IEA
    vascular endothelial growth factor binding GO:0038085 ISO
    semaphorin receptor activity GO:0017154 TAS
    growth factor binding GO:0019838 ISO
    heparin binding GO:0008201 IEA
    protein binding GO:0005515 IPI
Biological Process
    sensory neuron axon guidance GO:0097374 ISO
    protein localization to early endosome GO:1902946 ISO
    positive chemotaxis GO:0050918 ISO
    axonal fasciculation GO:0007413 ISO
    neuron development GO:0048666 ISO
    axon extension involved in axon guidance GO:0048846 ISO
    negative regulation of axon extension involved in axon guidance GO:0048843 ISO
    semaphorin-plexin signaling pathway involved in axon guidance GO:1902287 ISO
    peptidyl-tyrosine phosphorylation GO:0018108 ISO
    VEGF-activated neuropilin signaling pathway GO:0038190 ISO
    cellular response to hepatocyte growth factor stimulus GO:0035729 ISO
    hepatocyte growth factor receptor signaling pathway GO:0048012 ISO
    neural crest cell migration involved in autonomic nervous system development GO:1901166 ISO
    angiogenesis involved in coronary vascular morphogenesis GO:0060978 ISO
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO
    ganglion morphogenesis GO:0061552 ISO
    semaphorin-plexin signaling pathway involved in neuron projection guidance GO:1902285 ISO
    facioacoustic ganglion development GO:1903375 ISO
    cell migration involved in sprouting angiogenesis GO:0002042 ISO
    negative regulation of axon extension GO:0030517 ISO
    sympathetic neuron projection guidance GO:0097491 ISO
    cell migration GO:0016477 ISO
    neuron migration GO:0001764 ISO
    otic placode formation GO:0043049 ISO
    facial nerve structural organization GO:0021612 ISO
    retina vasculature morphogenesis in camera-type eye GO:0061299 ISO
    sympathetic nervous system development GO:0048485 ISO
    heart development GO:0007507 ISO
    vestibulocochlear nerve structural organization GO:0021649 ISO
    nerve development GO:0021675 ISO
    ventral trunk neural crest cell migration GO:0036486 ISO
    regulation of axon extension involved in axon guidance GO:0048841 ISO
    motor neuron axon guidance GO:0008045 ISO
    sprouting angiogenesis GO:0002040 ISO
    VEGF-activated neuropilin signaling pathway involved in axon guidance GO:1902378 ISO
    coronary artery morphogenesis GO:0060982 ISO
    positive regulation of axon extension involved in axon guidance GO:0048842 ISO
    response to wounding GO:0009611 IEP
    sympathetic neuron projection extension GO:0097490 ISO
    sympathetic ganglion development GO:0061549 ISO
    axonogenesis involved in innervation GO:0060385 ISO
    platelet-derived growth factor receptor signaling pathway GO:0048008 ISO
    branchiomotor neuron axon guidance GO:0021785 ISO
    patterning of blood vessels GO:0001569 ISO
    artery morphogenesis GO:0048844 ISO
    retinal ganglion cell axon guidance GO:0031290 ISO
    cellular response to vascular endothelial growth factor stimulus GO:0035924 ISO
    angiogenesis GO:0001525 ISO
    vascular endothelial growth factor receptor signaling pathway GO:0048010 ISO
    renal artery morphogenesis GO:0061441 ISO
    endothelial cell chemotaxis GO:0035767 ISO
    trigeminal nerve structural organization GO:0021637 ISO
    gonadotrophin-releasing hormone neuronal migration to the hypothalamus GO:0021828 ISO
    trigeminal ganglion development GO:0061551 ISO
    positive regulation of retinal ganglion cell axon guidance GO:1902336 ISO
    regulation of retinal ganglion cell axon guidance GO:0090259 ISO
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO
    trigeminal nerve morphogenesis GO:0021636 ISO
    dichotomous subdivision of terminal units involved in salivary gland branching GO:0060666 ISO
    dendrite development GO:0016358 ISO
    axon guidance GO:0007411 ISO
    nervous system development GO:0007399 NAS
    semaphorin-plexin signaling pathway GO:0071526 ISO
    toxin transport GO:1901998 ISO
    commissural neuron axon guidance GO:0071679 ISO
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 ISO
    negative regulation of neuron apoptotic process GO:0043524 ISO
Subcellular Localization
    focal adhesion GO:0005925 ISO
    sorting endosome GO:0097443 ISO
    growth cone GO:0030426 IDA
    cell surface GO:0009986 IDA
    cytosol GO:0005829 ISO
    neurofilament GO:0005883 ISO
    integral component of membrane GO:0016021 NAS
    axon GO:0030424 ISO
    extracellular space GO:0005615 ISO
    neuronal cell body GO:0043025 IDA
    plasma membrane GO:0005886 ISO
    early endosome GO:0005769 ISO
 Experiment description of studies that identified Nrp1 in exosomes
1
Experiment ID 90
ISEV standards
EM
EV Biophysical techniques
HSC70|HSP90|TSG101
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 94
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 96
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
4
Experiment ID 97
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
5
Experiment ID 98
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Nrp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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