Gene description for Nrp1
Gene name	neuropilin 1
Gene symbol	Nrp1
Other names/aliases	Nrp
Species	Rattus norvegicus
Database cross references - Nrp1
ExoCarta	ExoCarta_246331
Vesiclepedia	VP_246331
Entrez Gene	246331
UniProt	Q9QWJ9
Nrp1 identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Nrp1

Molecular Function     vascular endothelial growth factor receptor activity GO:0005021 IBA     vascular endothelial growth factor receptor activity GO:0005021 IEA     vascular endothelial growth factor receptor activity GO:0005021 ISO     GTPase activator activity GO:0005096 ISO     protein binding GO:0005515 IPI     heparin binding GO:0008201 IEA     semaphorin receptor activity GO:0017154 IBA     semaphorin receptor activity GO:0017154 IEA     semaphorin receptor activity GO:0017154 IMP     semaphorin receptor activity GO:0017154 ISO     semaphorin receptor activity GO:0017154 TAS     growth factor binding GO:0019838 ISO     protein kinase binding GO:0019901 ISO     vascular endothelial growth factor binding GO:0038085 IBA     vascular endothelial growth factor binding GO:0038085 ISO     metal ion binding GO:0046872 IEA Biological Process     angiogenesis GO:0001525 IEA     angiogenesis GO:0001525 ISO     angiogenesis GO:0001525 ISO     branching involved in blood vessel morphogenesis GO:0001569 ISO     branching involved in blood vessel morphogenesis GO:0001569 ISO     vasculogenesis GO:0001570 IBA     neural crest cell migration GO:0001755 IBA     neuron migration GO:0001764 ISO     sprouting angiogenesis GO:0002040 IBA     sprouting angiogenesis GO:0002040 ISO     cell migration involved in sprouting angiogenesis GO:0002042 ISO     outflow tract septum morphogenesis GO:0003148 ISO     cardiac neural crest cell migration involved in outflow tract morphogenesis GO:0003253 ISO     substrate-dependent cell migration, cell extension GO:0006930 ISO     integrin-mediated signaling pathway GO:0007229 ISO     nervous system development GO:0007399 NAS     axon guidance GO:0007411 IBA     axon guidance GO:0007411 IEA     axon guidance GO:0007411 ISO     axonal fasciculation GO:0007413 ISO     heart development GO:0007507 ISO     motor neuron axon guidance GO:0008045 ISO     response to wounding GO:0009611 IBA     positive regulation of endothelial cell migration GO:0010595 IBA     positive regulation of endothelial cell migration GO:0010595 ISO     positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641 IMP     dendrite development GO:0016358 ISO     facial nerve structural organization GO:0021612 ISO     trigeminal nerve morphogenesis GO:0021636 ISO     trigeminal nerve structural organization GO:0021637 ISO     vestibulocochlear nerve structural organization GO:0021649 ISO     branchiomotor neuron axon guidance GO:0021785 ISO     gonadotrophin-releasing hormone neuronal migration to the hypothalamus GO:0021828 ISO     negative regulation of axon extension GO:0030517 ISO     regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 IBA     retinal ganglion cell axon guidance GO:0031290 ISO     regulation of Cdc42 protein signal transduction GO:0032489 ISO     cellular response to hepatocyte growth factor stimulus GO:0035729 ISO     endothelial cell chemotaxis GO:0035767 ISO     cellular response to vascular endothelial growth factor stimulus GO:0035924 ISO     ventral trunk neural crest cell migration GO:0036486 ISO     vascular endothelial growth factor signaling pathway GO:0038084 IEA     neuropilin signaling pathway GO:0038189 ISO     VEGF-activated neuropilin signaling pathway GO:0038190 ISO     wound healing GO:0042060 IMP     positive regulation of phosphorylation GO:0042327 ISO     negative regulation of neuron apoptotic process GO:0043524 ISO     blood vessel endothelial cell migration GO:0043534 ISO     endothelial cell migration GO:0043542 ISO     positive regulation of angiogenesis GO:0045766 ISO     platelet-derived growth factor receptor signaling pathway GO:0048008 ISO     vascular endothelial growth factor receptor signaling pathway GO:0048010 IBA     vascular endothelial growth factor receptor signaling pathway GO:0048010 ISO     vascular endothelial growth factor receptor signaling pathway GO:0048010 ISO     hepatocyte growth factor receptor signaling pathway GO:0048012 ISO     sympathetic nervous system development GO:0048485 ISO     neuron development GO:0048666 ISO     axon extension GO:0048675 ISO     regulation of axon extension involved in axon guidance GO:0048841 ISO     positive regulation of axon extension involved in axon guidance GO:0048842 ISO     negative regulation of axon extension involved in axon guidance GO:0048843 IMP     negative regulation of axon extension involved in axon guidance GO:0048843 ISO     artery morphogenesis GO:0048844 ISO     axon extension involved in axon guidance GO:0048846 ISO     axon extension involved in axon guidance GO:0048846 ISO     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO     positive chemotaxis GO:0050918 ISO     positive regulation of filopodium assembly GO:0051491 IBA     positive regulation of filopodium assembly GO:0051491 ISO     positive regulation of stress fiber assembly GO:0051496 ISO     positive regulation of focal adhesion assembly GO:0051894 ISO     axonogenesis involved in innervation GO:0060385 ISO     dichotomous subdivision of terminal units involved in salivary gland branching GO:0060666 ISO     angiogenesis involved in coronary vascular morphogenesis GO:0060978 ISO     coronary artery morphogenesis GO:0060982 ISO     retina vasculature development in camera-type eye GO:0061298 ISO     retina vasculature morphogenesis in camera-type eye GO:0061299 ISO     renal artery morphogenesis GO:0061441 ISO     sympathetic ganglion development GO:0061549 ISO     trigeminal ganglion development GO:0061551 ISO     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO     semaphorin-plexin signaling pathway GO:0071526 IEA     semaphorin-plexin signaling pathway GO:0071526 ISO     semaphorin-plexin signaling pathway GO:0071526 ISO     positive regulation of smooth muscle cell chemotaxis GO:0071673 IMP     commissural neuron axon guidance GO:0071679 ISO     positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 ISO     sensory neuron axon guidance GO:0097374 ISO     motor neuron migration GO:0097475 ISO     motor neuron migration GO:0097475 ISS     sympathetic neuron projection extension GO:0097490 ISO     sympathetic neuron projection guidance GO:0097491 ISO     postsynapse organization GO:0099173 ISO     regulation of plasma membrane bounded cell projection organization GO:0120035 IEA     basal dendrite development GO:0150018 ISO     basal dendrite arborization GO:0150020 ISO     positive regulation of substrate adhesion-dependent cell spreading GO:1900026 ISO     neural crest cell migration involved in autonomic nervous system development GO:1901166 ISO     protein localization to early endosome GO:1902946 ISO     facioacoustic ganglion development GO:1903375 ISO     positive regulation of vascular associated smooth muscle cell migration GO:1904754 IMP     dorsal root ganglion morphogenesis GO:1904835 ISO     otic placode development GO:1905040 ISO     negative regulation of extrinsic apoptotic signaling pathway GO:2001237 ISO Subcellular Localization     early endosome GO:0005769 ISO     cytosol GO:0005829 ISO     neurofilament GO:0005883 ISO     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 ISO     focal adhesion GO:0005925 IBA     focal adhesion GO:0005925 ISO     cell surface GO:0009986 IDA     membrane GO:0016020 IEA     axon GO:0030424 IBA     axon GO:0030424 IDA     axon GO:0030424 ISO     growth cone GO:0030426 IDA     mitochondrial membrane GO:0031966 IEA     neuron projection GO:0043005 ISO     neuronal cell body GO:0043025 IDA     postsynaptic membrane GO:0045211 ISO     sorting endosome GO:0097443 ISO     glutamatergic synapse GO:0098978 ISO