Gene description for Vegfa
Gene name vascular endothelial growth factor A
Gene symbol Vegfa
Other names/aliases VEGF-A
VEGF164
VPF
Vegf
Species Rattus norvegicus
 Database cross references - Vegfa
ExoCarta ExoCarta_83785
Entrez Gene 83785
UniProt P16612  
 Vegfa identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Vegfa
Molecular Function
    growth factor activity GO:0008083 ISO
    receptor agonist activity GO:0048018 ISO
    vascular endothelial growth factor receptor 2 binding GO:0043184 ISO
    cytokine activity GO:0005125 ISO
    neuropilin binding GO:0038191 ISO
    protein homodimerization activity GO:0042803 IDA
    extracellular matrix binding GO:0050840 ISO
    fibronectin binding GO:0001968 ISO
    identical protein binding GO:0042802 ISO
    protein heterodimerization activity GO:0046982 ISO
    platelet-derived growth factor receptor binding GO:0005161 ISO
    vascular endothelial growth factor receptor binding GO:0005172 TAS
    chemoattractant activity GO:0042056 ISO
    receptor binding GO:0005102 ISO
    vascular endothelial growth factor receptor 1 binding GO:0043183 ISO
    heparin binding GO:0008201 ISO
Biological Process
    in utero embryonic development GO:0001701 ISO
    eye photoreceptor cell development GO:0042462 ISO
    regulation of endothelial cell differentiation GO:0045601 ISO
    positive regulation of protein complex assembly GO:0031334 ISS
    positive regulation of protein kinase D signaling GO:1903572 ISO
    positive regulation of endothelial cell migration GO:0010595 ISS
    positive regulation of retinal ganglion cell axon guidance GO:1902336 ISO
    coronary vein morphogenesis GO:0003169 ISO
    surfactant homeostasis GO:0043129 ISO
    positive chemotaxis GO:0050918 ISO
    sprouting angiogenesis GO:0002040 ISO
    response to estradiol GO:0032355 IEP
    regulation of transcription from RNA polymerase II promoter GO:0006357 ISO
    vascular endothelial growth factor receptor signaling pathway GO:0048010 ISO
    positive regulation of mesenchymal cell proliferation GO:0002053 ISO
    ovarian follicle development GO:0001541 ISO
    negative regulation of programmed cell death GO:0043069 IMP
    tube formation GO:0035148 ISS
    positive regulation of cellular component movement GO:0051272 ISO
    outflow tract morphogenesis GO:0003151 ISO
    post-embryonic camera-type eye development GO:0031077 ISO
    positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 ISO
    activation of protein kinase activity GO:0032147 ISO
    mesoderm development GO:0007498 ISO
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    lung development GO:0030324 ISO
    positive regulation of protein autophosphorylation GO:0031954 ISO
    response to cold GO:0009409 IEP
    positive regulation of receptor internalization GO:0002092 ISO
    positive regulation of p38MAPK cascade GO:1900745 ISO
    positive regulation of protein kinase C signaling GO:0090037 ISO
    cell maturation GO:0048469 ISO
    positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 ISO
    positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 ISO
    lymphangiogenesis GO:0001946 ISO
    positive regulation of signal transduction GO:0009967 IDA
    positive regulation of gene expression GO:0010628 ISO
    lung vasculature development GO:0060426 ISO
    cellular response to drug GO:0035690 IEP
    VEGF-activated neuropilin signaling pathway GO:0038190 ISO
    response to progesterone GO:0032570 IEP
    patterning of blood vessels GO:0001569 ISO
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    branching morphogenesis of an epithelial tube GO:0048754 ISO
    positive regulation of CREB transcription factor activity GO:0032793 ISO
    positive regulation of smooth muscle cell proliferation GO:0048661 IMP
    angiogenesis involved in coronary vascular morphogenesis GO:0060978 IMP
    response to folic acid GO:0051593 IEP
    wound healing GO:0042060 IEP
    T-helper 1 type immune response GO:0042088 IDA
    positive regulation of lymphangiogenesis GO:1901492 ISO
    positive regulation of positive chemotaxis GO:0050927 ISO
    vasculature development GO:0001944 ISO
    monocyte differentiation GO:0030224 ISO
    lymph vessel morphogenesis GO:0036303 ISO
    positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 ISO
    aging GO:0007568 IEP
    camera-type eye morphogenesis GO:0048593 ISO
    regulation of cGMP metabolic process GO:0030823 ISO
    positive regulation of peptidyl-serine phosphorylation GO:0033138 ISO
    endothelial cell migration GO:0043542 ISO
    positive regulation of angiogenesis GO:0045766 ISS
    growth GO:0040007 ISO
    heart morphogenesis GO:0003007 ISO
    regulation of retinal ganglion cell axon guidance GO:0090259 ISO
    positive regulation of axon extension involved in axon guidance GO:0048842 ISO
    cellular response to dexamethasone stimulus GO:0071549 IEP
    regulation of hematopoietic progenitor cell differentiation GO:1901532 ISO
    cell chemotaxis GO:0060326 IMP
    primitive erythrocyte differentiation GO:0060319 ISO
    positive regulation of protein kinase B signaling GO:0051897 ISO
    hyaluronan metabolic process GO:0030212 IEP
    angiogenesis GO:0001525 TAS
    epithelial cell differentiation GO:0030855 ISO
    blood vessel development GO:0001568 ISO
    positive regulation of cell proliferation GO:0008284 TAS
    coronary artery morphogenesis GO:0060982 ISO
    positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 ISO
    positive regulation of mast cell chemotaxis GO:0060754 ISO
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 ISO
    lactation GO:0007595 ISO
    female pregnancy GO:0007565 IEP
    mRNA stabilization GO:0048255 IDA
    positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038091 ISO
    positive regulation of endothelial cell proliferation GO:0001938 ISS
    positive regulation of neuroblast proliferation GO:0002052 ISO
    cell migration GO:0016477 ISO
    blood vessel morphogenesis GO:0048514 ISO
    negative regulation of neuron apoptotic process GO:0043524 ISO
    macrophage differentiation GO:0030225 ISO
    nervous system development GO:0007399 NAS
    positive regulation of MAP kinase activity GO:0043406 ISO
    negative regulation of apoptotic process GO:0043066 ISO
    positive regulation of vascular permeability GO:0043117 ISO
    response to dexamethasone GO:0071548 IEP
    induction of positive chemotaxis GO:0050930 ISO
    response to hypoxia GO:0001666 ISO
    response to vitamin A GO:0033189 IEP
    negative regulation of cell-cell adhesion GO:0022408 ISO
    positive regulation of cell division GO:0051781 IEA
    negative regulation of neuron death GO:1901215 IMP
    artery morphogenesis GO:0048844 ISO
    response to oxygen levels GO:0070482 IEP
    cellular response to hypoxia GO:0071456 ISO
    vascular endothelial growth factor signaling pathway GO:0038084 ISO
    kidney development GO:0001822 ISO
    cellular response to fibroblast growth factor stimulus GO:0044344 IEP
    positive regulation of cell migration GO:0030335 ISO
    endothelial cell chemotaxis GO:0035767 ISO
    dopaminergic neuron differentiation GO:0071542 ISO
    regulation of cell shape GO:0008360 ISO
    positive regulation of epithelial cell proliferation GO:0050679 ISO
    positive regulation of protein localization to early endosome GO:1902966 ISO
    positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 ISO
    basophil chemotaxis GO:0002575 ISO
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO
    lung alveolus development GO:0048286 IMP
    commissural neuron axon guidance GO:0071679 ISO
    positive regulation of protein phosphorylation GO:0001934 ISS
    cell proliferation GO:0008283 ISO
    cell differentiation GO:0030154 IEA
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 ISO
    cell migration involved in sprouting angiogenesis GO:0002042 ISO
    negative regulation of bone resorption GO:0045779 IMP
    blood vessel remodeling GO:0001974 IMP
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISS
    positive regulation of histone deacetylase activity GO:1901727 ISO
    positive regulation of cell adhesion GO:0045785 ISO
    positive regulation of blood vessel endothelial cell migration GO:0043536 ISO
    positive regulation of focal adhesion assembly GO:0051894 ISS
    neuron development GO:0048666 ISO
    cardiac vascular smooth muscle cell development GO:0060948 ISO
    cardiac muscle fiber development GO:0048739 ISO
    cellular response to vascular endothelial growth factor stimulus GO:0035924 ISO
    mammary gland alveolus development GO:0060749 ISO
Subcellular Localization
    extracellular region GO:0005576 ISO
    cell surface GO:0009986 ISO
    extracellular space GO:0005615 ISO
    cytoplasm GO:0005737 ISO
    membrane GO:0016020 IEA
    secretory granule GO:0030141 ISO
    basement membrane GO:0005604 IDA
    membrane-bounded vesicle GO:0031988 IDA
 Experiment description of studies that identified Vegfa in exosomes
1
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method RT-PCR
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method RT-PCR
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Vegfa
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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