Gene description for Vegfa
Gene name	vascular endothelial growth factor A
Gene symbol	Vegfa
Other names/aliases	VEGF-A VEGF164 VPF Vegf
Species	Rattus norvegicus
Database cross references - Vegfa
ExoCarta	ExoCarta_83785
Vesiclepedia	VP_83785
Entrez Gene	83785
UniProt	P16612
Vegfa identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells	20124479
Pancreatic cancer cells	20124479

Gene ontology annotations for Vegfa

Molecular Function     fibronectin binding GO:0001968 IEA     fibronectin binding GO:0001968 ISO     cytokine activity GO:0005125 IEA     cytokine activity GO:0005125 ISO     platelet-derived growth factor receptor binding GO:0005161 IEA     platelet-derived growth factor receptor binding GO:0005161 ISO     vascular endothelial growth factor receptor binding GO:0005172 IBA     vascular endothelial growth factor receptor binding GO:0005172 ISO     vascular endothelial growth factor receptor binding GO:0005172 TAS     growth factor activity GO:0008083 IBA     growth factor activity GO:0008083 IDA     growth factor activity GO:0008083 IEA     growth factor activity GO:0008083 ISO     heparin binding GO:0008201 IEA     heparin binding GO:0008201 ISO     growth factor binding GO:0019838 IPI     transmembrane receptor protein tyrosine kinase activator activity GO:0030297 IEA     transmembrane receptor protein tyrosine kinase activator activity GO:0030297 ISO     neuropilin binding GO:0038191 ISO     chemoattractant activity GO:0042056 IBA     chemoattractant activity GO:0042056 IEA     chemoattractant activity GO:0042056 IMP     chemoattractant activity GO:0042056 ISO     identical protein binding GO:0042802 IEA     identical protein binding GO:0042802 IPI     identical protein binding GO:0042802 ISO     vascular endothelial growth factor receptor 1 binding GO:0043183 IEA     vascular endothelial growth factor receptor 1 binding GO:0043183 ISO     vascular endothelial growth factor receptor 2 binding GO:0043184 IEA     vascular endothelial growth factor receptor 2 binding GO:0043184 IMP     vascular endothelial growth factor receptor 2 binding GO:0043184 ISO     receptor ligand activity GO:0048018 ISO Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IEA     negative regulation of transcription by RNA polymerase II GO:0000122 ISO     angiogenesis GO:0001525 IEA     angiogenesis GO:0001525 IMP     angiogenesis GO:0001525 ISO     angiogenesis GO:0001525 ISO     angiogenesis GO:0001525 TAS     ovarian follicle development GO:0001541 ISO     blood vessel development GO:0001568 ISO     branching involved in blood vessel morphogenesis GO:0001569 IEA     branching involved in blood vessel morphogenesis GO:0001569 ISO     branching involved in blood vessel morphogenesis GO:0001569 ISO     response to hypoxia GO:0001666 IBA     response to hypoxia GO:0001666 IDA     response to hypoxia GO:0001666 ISO     in utero embryonic development GO:0001701 ISO     kidney development GO:0001822 ISO     positive regulation of protein phosphorylation GO:0001934 ISO     positive regulation of protein phosphorylation GO:0001934 ISS     endothelial cell proliferation GO:0001935 ISO     positive regulation of endothelial cell proliferation GO:0001938 ISO     positive regulation of endothelial cell proliferation GO:0001938 ISO     positive regulation of endothelial cell proliferation GO:0001938 ISS     vasculature development GO:0001944 ISO     lymphangiogenesis GO:0001946 ISO     lymphangiogenesis GO:0001946 ISO     blood vessel remodeling GO:0001974 IMP     sprouting angiogenesis GO:0002040 IBA     sprouting angiogenesis GO:0002040 ISO     cell migration involved in sprouting angiogenesis GO:0002042 IEA     cell migration involved in sprouting angiogenesis GO:0002042 ISO     positive regulation of neuroblast proliferation GO:0002052 ISO     epithelial cell maturation GO:0002070 ISO     positive regulation of receptor internalization GO:0002092 IEA     positive regulation of receptor internalization GO:0002092 ISO     basophil chemotaxis GO:0002575 ISO     heart morphogenesis GO:0003007 ISO     outflow tract morphogenesis GO:0003151 ISO     coronary vein morphogenesis GO:0003169 ISO     regulation of transcription by RNA polymerase II GO:0006357 ISO     apoptotic process GO:0006915 ISO     signal transduction GO:0007165 IEA     phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 IEA     phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 ISO     nervous system development GO:0007399 IDA     nervous system development GO:0007399 NAS     neuroblast proliferation GO:0007405 ISO     mesoderm development GO:0007498 ISO     female pregnancy GO:0007565 IEP     lactation GO:0007595 ISO     cell population proliferation GO:0008283 ISO     positive regulation of cell population proliferation GO:0008284 IMP     positive regulation of cell population proliferation GO:0008284 ISO     positive regulation of cell population proliferation GO:0008284 ISO     positive regulation of cell population proliferation GO:0008284 TAS     regulation of cell shape GO:0008360 IEA     regulation of cell shape GO:0008360 ISO     positive regulation of signal transduction GO:0009967 IDA     positive regulation of endothelial cell migration GO:0010595 ISO     positive regulation of endothelial cell migration GO:0010595 ISS     positive regulation of gene expression GO:0010628 IEA     positive regulation of gene expression GO:0010628 ISO     negative regulation of gene expression GO:0010629 IEA     negative regulation of gene expression GO:0010629 ISO     negative regulation of gene expression GO:0010629 ISO     negative regulation of epithelial to mesenchymal transition GO:0010719 ISO     regulation of nitric oxide mediated signal transduction GO:0010749 IEA     regulation of nitric oxide mediated signal transduction GO:0010749 ISO     cell migration GO:0016477 ISO     peptidyl-tyrosine phosphorylation GO:0018108 ISO     negative regulation of cell-cell adhesion GO:0022408 ISO     cell differentiation GO:0030154 IEA     monocyte differentiation GO:0030224 IEA     monocyte differentiation GO:0030224 ISO     macrophage differentiation GO:0030225 IEA     macrophage differentiation GO:0030225 ISO     lung development GO:0030324 ISO     positive regulation of cell migration GO:0030335 ISO     epithelial cell differentiation GO:0030855 ISO     post-embryonic camera-type eye development GO:0031077 ISO     retinal ganglion cell axon guidance GO:0031290 ISO     retinal ganglion cell axon guidance GO:0031290 ISO     positive regulation of protein-containing complex assembly GO:0031334 IEA     positive regulation of protein-containing complex assembly GO:0031334 ISO     positive regulation of protein-containing complex assembly GO:0031334 ISS     positive regulation of protein autophosphorylation GO:0031954 ISO     response to estradiol GO:0032355 IEP     response to progesterone GO:0032570 IEP     response to vitamin A GO:0033189 IEP     tube formation GO:0035148 IEA     tube formation GO:0035148 ISO     tube formation GO:0035148 ISS     endothelial cell chemotaxis GO:0035767 IEA     endothelial cell chemotaxis GO:0035767 ISO     cellular response to vascular endothelial growth factor stimulus GO:0035924 ISO     lymph vessel morphogenesis GO:0036303 ISO     vascular endothelial growth factor receptor-2 signaling pathway GO:0036324 IEA     vascular endothelial growth factor receptor-2 signaling pathway GO:0036324 ISO     positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 IEA     positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 ISO     vascular endothelial growth factor signaling pathway GO:0038084 IBA     vascular endothelial growth factor signaling pathway GO:0038084 ISO     positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038091 IEA     positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038091 ISO     VEGF-activated neuropilin signaling pathway GO:0038190 ISO     regulation of growth GO:0040008 ISO     T-helper 1 type immune response GO:0042088 IDA     vasodilation GO:0042311 ISO     eye photoreceptor cell development GO:0042462 ISO     negative regulation of apoptotic process GO:0043066 IEA     negative regulation of apoptotic process GO:0043066 ISO     negative regulation of apoptotic process GO:0043066 ISO     negative regulation of programmed cell death GO:0043069 IMP     positive regulation of vascular permeability GO:0043117 IEA     positive regulation of vascular permeability GO:0043117 IMP     positive regulation of vascular permeability GO:0043117 ISO     positive regulation of vascular permeability GO:0043117 ISO     surfactant homeostasis GO:0043129 ISO     positive regulation of MAPK cascade GO:0043410 ISO     negative regulation of neuron apoptotic process GO:0043524 ISO     positive regulation of blood vessel endothelial cell migration GO:0043536 ISO     endothelial cell migration GO:0043542 ISO     cellular response to fibroblast growth factor stimulus GO:0044344 IEP     negative regulation of fat cell differentiation GO:0045599 ISO     regulation of endothelial cell differentiation GO:0045601 ISO     positive regulation of osteoblast differentiation GO:0045669 ISO     positive regulation of angiogenesis GO:0045766 IDA     positive regulation of angiogenesis GO:0045766 ISO     positive regulation of angiogenesis GO:0045766 ISO     positive regulation of angiogenesis GO:0045766 ISS     negative regulation of bone resorption GO:0045779 IMP     positive regulation of cell adhesion GO:0045785 ISO     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IEA     positive regulation of transcription by RNA polymerase II GO:0045944 ISO     vascular endothelial growth factor receptor signaling pathway GO:0048010 IBA     vascular endothelial growth factor receptor signaling pathway GO:0048010 IMP     vascular endothelial growth factor receptor signaling pathway GO:0048010 ISO     mRNA stabilization GO:0048255 IDA     lung alveolus development GO:0048286 IMP     blood vessel morphogenesis GO:0048514 ISO     camera-type eye morphogenesis GO:0048593 ISO     positive regulation of smooth muscle cell proliferation GO:0048661 IMP     neuron development GO:0048666 ISO     tissue remodeling GO:0048771 IEP     positive regulation of axon extension involved in axon guidance GO:0048842 ISO     positive regulation of axon extension involved in axon guidance GO:0048842 ISO     artery morphogenesis GO:0048844 ISO     homeostasis of number of cells within a tissue GO:0048873 ISO     epithelial cell proliferation GO:0050673 ISO     positive regulation of epithelial cell proliferation GO:0050679 ISO     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISS     positive chemotaxis GO:0050918 IEA     positive chemotaxis GO:0050918 ISO     positive regulation of positive chemotaxis GO:0050927 IEA     positive regulation of positive chemotaxis GO:0050927 ISO     induction of positive chemotaxis GO:0050930 IBA     induction of positive chemotaxis GO:0050930 ISO     neuron apoptotic process GO:0051402 IMP     response to folic acid GO:0051593 IEP     positive regulation of cell division GO:0051781 IEA     positive regulation of focal adhesion assembly GO:0051894 IEA     positive regulation of focal adhesion assembly GO:0051894 ISO     positive regulation of focal adhesion assembly GO:0051894 ISS     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO     cardiac muscle cell development GO:0055013 ISO     primitive erythrocyte differentiation GO:0060319 ISO     cell chemotaxis GO:0060326 IMP     bone trabecula formation GO:0060346 ISO     lung vasculature development GO:0060426 ISO     mammary gland alveolus development GO:0060749 ISO     positive regulation of mast cell chemotaxis GO:0060754 IBA     positive regulation of mast cell chemotaxis GO:0060754 ISO     cardiac vascular smooth muscle cell development GO:0060948 ISO     angiogenesis involved in coronary vascular morphogenesis GO:0060978 IMP     coronary artery morphogenesis GO:0060982 ISO     vascular wound healing GO:0061042 IEA     vascular wound healing GO:0061042 ISO     bone trabecula morphogenesis GO:0061430 ISO     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO     response to oxygen levels GO:0070482 IEP     cellular response to mechanical stimulus GO:0071260 IEP     cellular response to estrogen stimulus GO:0071391 IEP     cellular response to hypoxia GO:0071456 IEA     cellular response to hypoxia GO:0071456 ISO     cellular response to hypoxia GO:0071456 ISO     cellular response to xenobiotic stimulus GO:0071466 IEP     dopaminergic neuron differentiation GO:0071542 ISO     response to dexamethasone GO:0071548 IEP     cellular response to dexamethasone stimulus GO:0071549 IEP     commissural neuron axon guidance GO:0071679 ISO     commissural neuron axon guidance GO:0071679 ISO     positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 IEA     positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 ISO     positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 ISO     motor neuron migration GO:0097475 ISO     motor neuron migration GO:0097475 ISS     cellular stress response to acid chemical GO:0097533 IEA     cellular stress response to acid chemical GO:0097533 ISO     cell-cell adhesion GO:0098609 ISO     positive regulation of cold-induced thermogenesis GO:0120162 ISO     positive regulation of cold-induced thermogenesis GO:0120162 ISS     positive regulation of p38MAPK cascade GO:1900745 IEA     positive regulation of p38MAPK cascade GO:1900745 ISO     positive regulation of vascular endothelial growth factor signaling pathway GO:1900748 IEA     positive regulation of vascular endothelial growth factor signaling pathway GO:1900748 ISO     positive regulation of trophoblast cell migration GO:1901165 IEA     positive regulation of trophoblast cell migration GO:1901165 ISO     positive regulation of lymphangiogenesis GO:1901492 ISO     regulation of hematopoietic progenitor cell differentiation GO:1901532 ISO     positive regulation of protein localization to early endosome GO:1902966 ISO     negative regulation of establishment of endothelial barrier GO:1903141 IEA     negative regulation of establishment of endothelial barrier GO:1903141 ISO     negative regulation of adherens junction organization GO:1903392 IEA     negative regulation of adherens junction organization GO:1903392 ISO     positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 IEA     positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 ISO     positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 ISO     positive regulation of sprouting angiogenesis GO:1903672 IEA     positive regulation of sprouting angiogenesis GO:1903672 ISO     cellular response to wortmannin GO:1904568 IEP     positive regulation of epithelial tube formation GO:1905278 ISO     negative regulation of blood-brain barrier permeability GO:1905604 IEA     negative regulation of blood-brain barrier permeability GO:1905604 ISO     negative regulation of cell-cell adhesion mediated by cadherin GO:2000048 IEA     negative regulation of cell-cell adhesion mediated by cadherin GO:2000048 ISO     negative regulation of cysteine-type endopeptidase activity GO:2000117 ISO     positive regulation of DNA biosynthetic process GO:2000573 ISO     positive regulation of endothelial cell chemotaxis GO:2001028 ISO     negative regulation of extrinsic apoptotic signaling pathway GO:2001237 ISO Subcellular Localization     extracellular region GO:0005576 IEA     basement membrane GO:0005604 IDA     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IDA     extracellular space GO:0005615 IEA     extracellular space GO:0005615 ISO     nucleus GO:0005634 ISO     cytoplasm GO:0005737 ISO     adherens junction GO:0005912 IEA     adherens junction GO:0005912 ISO     cell surface GO:0009986 IEA     cell surface GO:0009986 ISO     membrane GO:0016020 IEA     secretory granule GO:0030141 IEA     secretory granule GO:0030141 ISO     vesicle GO:0031982 IDA     VEGF-A complex GO:1990150 IEA     VEGF-A complex GO:1990150 ISO