Gene description for Sod1
Gene name	superoxide dismutase 1, soluble
Gene symbol	Sod1
Other names/aliases	CuZnSOD
Species	Rattus norvegicus
Database cross references - Sod1
ExoCarta	ExoCarta_24786
Vesiclepedia	VP_24786
Entrez Gene	24786
UniProt	P07632
Sod1 identified in exosomes derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Urine	20535238

Gene ontology annotations for Sod1

Molecular Function     superoxide dismutase activity GO:0004784 IBA     superoxide dismutase activity GO:0004784 IDA     superoxide dismutase activity GO:0004784 IEA     superoxide dismutase activity GO:0004784 IMP     superoxide dismutase activity GO:0004784 ISO     superoxide dismutase activity GO:0004784 ISS     copper ion binding GO:0005507 IBA     copper ion binding GO:0005507 IEA     copper ion binding GO:0005507 IMP     copper ion binding GO:0005507 ISO     copper ion binding GO:0005507 ISS     copper ion binding GO:0005507 TAS     zinc ion binding GO:0008270 IEA     zinc ion binding GO:0008270 ISO     zinc ion binding GO:0008270 ISS     enzyme binding GO:0019899 IPI     protein phosphatase 2B binding GO:0030346 IDA     protein phosphatase 2B binding GO:0030346 IEA     protein phosphatase 2B binding GO:0030346 ISO     protein phosphatase 2B binding GO:0030346 ISS     small GTPase binding GO:0031267 IEA     small GTPase binding GO:0031267 ISO     identical protein binding GO:0042802 ISO     protein homodimerization activity GO:0042803 IEA     protein homodimerization activity GO:0042803 ISO     protein-folding chaperone binding GO:0051087 IEA     protein-folding chaperone binding GO:0051087 ISO     protein-folding chaperone binding GO:0051087 ISS Biological Process     response to reactive oxygen species GO:0000302 ISO     response to superoxide GO:0000303 ISO     response to superoxide GO:0000303 ISO     response to superoxide GO:0000303 ISS     ovarian follicle development GO:0001541 ISO     ovarian follicle development GO:0001541 ISS     positive regulation of cytokine production GO:0001819 IEA     positive regulation of cytokine production GO:0001819 ISO     positive regulation of cytokine production GO:0001819 ISS     retina homeostasis GO:0001895 ISO     retina homeostasis GO:0001895 ISS     response to amphetamine GO:0001975 IEP     myeloid cell homeostasis GO:0002262 ISO     myeloid cell homeostasis GO:0002262 ISS     glutathione metabolic process GO:0006749 ISO     glutathione metabolic process GO:0006749 ISS     superoxide metabolic process GO:0006801 IDA     superoxide metabolic process GO:0006801 ISO     superoxide metabolic process GO:0006801 ISO     superoxide metabolic process GO:0006801 ISS     superoxide metabolic process GO:0006801 TAS     intracellular iron ion homeostasis GO:0006879 ISO     intracellular iron ion homeostasis GO:0006879 ISS     apoptotic process GO:0006915 ISO     response to oxidative stress GO:0006979 IMP     response to oxidative stress GO:0006979 ISO     response to oxidative stress GO:0006979 TAS     spermatogenesis GO:0007283 ISO     spermatogenesis GO:0007283 ISS     embryo implantation GO:0007566 ISO     embryo implantation GO:0007566 ISS     sensory perception of sound GO:0007605 ISO     sensory perception of sound GO:0007605 ISS     locomotory behavior GO:0007626 ISO     locomotory behavior GO:0007626 ISS     anterograde axonal transport GO:0008089 ISO     retrograde axonal transport GO:0008090 ISO     regulation of blood pressure GO:0008217 ISO     regulation of blood pressure GO:0008217 ISS     determination of adult lifespan GO:0008340 ISO     response to heat GO:0009408 ISO     response to heat GO:0009408 ISS     response to xenobiotic stimulus GO:0009410 ISO     gene expression GO:0010467 ISO     transmission of nerve impulse GO:0019226 ISO     transmission of nerve impulse GO:0019226 ISS     neuronal action potential GO:0019228 ISO     removal of superoxide radicals GO:0019430 IBA     removal of superoxide radicals GO:0019430 IDA     removal of superoxide radicals GO:0019430 IEA     removal of superoxide radicals GO:0019430 IMP     removal of superoxide radicals GO:0019430 ISO     removal of superoxide radicals GO:0019430 ISO     removal of superoxide radicals GO:0019430 ISS     removal of superoxide radicals GO:0019430 TAS     response to nutrient levels GO:0031667 IDA     response to nutrient levels GO:0031667 IEP     peripheral nervous system myelin maintenance GO:0032287 ISO     peripheral nervous system myelin maintenance GO:0032287 ISS     positive regulation of superoxide anion generation GO:0032930 IEA     positive regulation of superoxide anion generation GO:0032930 ISO     response to carbon monoxide GO:0034465 IEP     cellular response to oxidative stress GO:0034599 IEP     ectopic germ cell programmed cell death GO:0035234 ISO     cellular response to potassium ion GO:0035865 IEP     regulation of multicellular organism growth GO:0040014 ISO     regulation of multicellular organism growth GO:0040014 ISS     response to hydrogen peroxide GO:0042542 ISO     response to hydrogen peroxide GO:0042542 ISS     superoxide anion generation GO:0042554 ISO     negative regulation of apoptotic process GO:0043066 IMP     negative regulation of apoptotic process GO:0043066 ISO     positive regulation of catalytic activity GO:0043085 IDA     positive regulation of MAPK cascade GO:0043410 ISO     positive regulation of MAPK cascade GO:0043410 ISS     negative regulation of neuron apoptotic process GO:0043524 ISO     negative regulation of neuron apoptotic process GO:0043524 ISS     response to ethanol GO:0045471 ISO     response to ethanol GO:0045471 ISS     response to copper ion GO:0046688 IEP     response to copper ion GO:0046688 IMP     muscle cell cellular homeostasis GO:0046716 ISO     muscle cell cellular homeostasis GO:0046716 ISS     response to axon injury GO:0048678 ISO     response to axon injury GO:0048678 ISS     hydrogen peroxide biosynthetic process GO:0050665 IDA     hydrogen peroxide biosynthetic process GO:0050665 IEA     hydrogen peroxide biosynthetic process GO:0050665 IMP     hydrogen peroxide biosynthetic process GO:0050665 ISO     hydrogen peroxide biosynthetic process GO:0050665 ISO     hydrogen peroxide biosynthetic process GO:0050665 ISS     negative regulation of inflammatory response GO:0050728 ISO     positive regulation of phagocytosis GO:0050766 ISO     negative regulation of developmental process GO:0051093 ISO     regulation of mitochondrial membrane potential GO:0051881 IEA     regulation of mitochondrial membrane potential GO:0051881 ISO     regulation of mitochondrial membrane potential GO:0051881 ISS     heart contraction GO:0060047 IEA     heart contraction GO:0060047 ISO     heart contraction GO:0060047 ISO     heart contraction GO:0060047 ISS     neurofilament cytoskeleton organization GO:0060052 ISO     neurofilament cytoskeleton organization GO:0060052 ISS     relaxation of vascular associated smooth muscle GO:0060087 ISO     relaxation of vascular associated smooth muscle GO:0060087 ISS     auditory receptor cell stereocilium organization GO:0060088 ISO     auditory receptor cell stereocilium organization GO:0060088 ISS     cellular response to cadmium ion GO:0071276 IEP     cellular response to ATP GO:0071318 IEP     reactive oxygen species metabolic process GO:0072593 ISO     reactive oxygen species metabolic process GO:0072593 ISS     response to antipsychotic drug GO:0097332 IEP     action potential initiation GO:0099610 ISO     positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902177 IEA     positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902177 ISO     negative regulation of reproductive process GO:2000242 ISO Subcellular Localization     extracellular region GO:0005576 IDA     extracellular space GO:0005615 IEA     extracellular space GO:0005615 ISO     nucleus GO:0005634 IBA     nucleus GO:0005634 ISO     nucleus GO:0005634 ISS     nucleoplasm GO:0005654 IEA     nucleoplasm GO:0005654 ISO     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 ISS     mitochondrion GO:0005739 IBA     mitochondrion GO:0005739 IEA     mitochondrion GO:0005739 ISO     mitochondrion GO:0005739 ISS     lysosome GO:0005764 IDA     peroxisome GO:0005777 IBA     peroxisome GO:0005777 IDA     peroxisome GO:0005777 IEA     peroxisome GO:0005777 ISO     cytosol GO:0005829 IBA     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     cytosol GO:0005829 ISS     plasma membrane GO:0005886 IEA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISS     secretory granule GO:0030141 IDA     dense core granule GO:0031045 IDA     cytoplasmic vesicle GO:0031410 IEA     cytoplasmic vesicle GO:0031410 ISO     cytoplasmic vesicle GO:0031410 ISS     dendrite cytoplasm GO:0032839 IEA     dendrite cytoplasm GO:0032839 ISO     dendrite cytoplasm GO:0032839 ISS     protein-containing complex GO:0032991 IDA     protein-containing complex GO:0032991 IEA     protein-containing complex GO:0032991 ISO     protein-containing complex GO:0032991 ISS     neuronal cell body GO:0043025 IDA     neuronal cell body GO:0043025 IEA     neuronal cell body GO:0043025 ISO     neuronal cell body GO:0043025 ISS     axon cytoplasm GO:1904115 IEA