Gene description for Park7
Gene name	parkinson protein 7
Gene symbol	Park7
Other names/aliases	CAP1 DJ-1 Dj1 SP22
Species	Rattus norvegicus
Database cross references - Park7
ExoCarta	ExoCarta_117287
Vesiclepedia	VP_117287
Entrez Gene	117287
UniProt	O88767
Park7 identified in exosomes derived from the following tissue/cell type
Urine	20535238

Gene ontology annotations for Park7

Molecular Function     double-stranded DNA binding GO:0003690 ISO     single-stranded DNA binding GO:0003697 ISO     transcription coactivator activity GO:0003713 ISO     transcription coactivator activity GO:0003713 ISS     mRNA binding GO:0003729 ISO     mRNA binding GO:0003729 ISS     signaling receptor binding GO:0005102 ISO     signaling receptor binding GO:0005102 ISS     copper ion binding GO:0005507 ISO     copper ion binding GO:0005507 ISS     protein binding GO:0005515 IPI     enzyme activator activity GO:0008047 ISO     enzyme activator activity GO:0008047 ISS     peptidase activity GO:0008233 IEA     peptidase activity GO:0008233 ISO     peptidase activity GO:0008233 ISS     superoxide dismutase copper chaperone activity GO:0016532 ISO     superoxide dismutase copper chaperone activity GO:0016532 ISS     oxidoreductase activity, acting on peroxide as acceptor GO:0016684 IBA     oxidoreductase activity, acting on peroxide as acceptor GO:0016684 ISO     oxygen sensor activity GO:0019826 ISO     enzyme binding GO:0019899 ISO     kinase binding GO:0019900 ISO     cytokine binding GO:0019955 ISO     cytokine binding GO:0019955 ISS     peptidase inhibitor activity GO:0030414 ISO     peptidase inhibitor activity GO:0030414 ISS     signaling receptor activator activity GO:0030546 ISO     tyrosine 3-monooxygenase activator activity GO:0036470 ISO     tyrosine 3-monooxygenase activator activity GO:0036470 ISS     L-dopa decarboxylase activator activity GO:0036478 ISO     L-dopa decarboxylase activator activity GO:0036478 ISS     protein deglycase activity GO:0036524 IEA     protein deglycase activity GO:0036524 ISO     protein deglycase activity GO:0036524 ISO     protein deglycase activity GO:0036524 ISS     protein deglycase activity GO:0036524 ISS     identical protein binding GO:0042802 ISO     protein homodimerization activity GO:0042803 ISO     protein homodimerization activity GO:0042803 ISS     small protein activating enzyme binding GO:0044388 ISO     small protein activating enzyme binding GO:0044388 ISS     ubiquitin-like protein conjugating enzyme binding GO:0044390 ISO     ubiquitin-like protein conjugating enzyme binding GO:0044390 ISS     mercury ion binding GO:0045340 ISO     mercury ion binding GO:0045340 ISS     nuclear androgen receptor binding GO:0050681 ISO     nuclear androgen receptor binding GO:0050681 ISS     peroxiredoxin activity GO:0051920 ISO     ubiquitin-protein transferase inhibitor activity GO:0055105 ISO     scaffold protein binding GO:0097110 ISO     scaffold protein binding GO:0097110 ISS     DNA-binding transcription factor binding GO:0140297 ISO     DNA-binding transcription factor binding GO:0140297 ISS     cupric ion binding GO:1903135 ISO     cupric ion binding GO:1903135 ISS     cuprous ion binding GO:1903136 ISO     cuprous ion binding GO:1903136 ISS     ubiquitin-specific protease binding GO:1990381 ISO     glyoxalase (glycolic acid-forming) activity GO:1990422 ISO     glyoxalase (glycolic acid-forming) activity GO:1990422 ISS Biological Process     negative regulation of protein phosphorylation GO:0001933 ISO     negative regulation of protein phosphorylation GO:0001933 ISS     synaptic transmission, dopaminergic GO:0001963 ISO     positive regulation of acute inflammatory response to antigenic stimulus GO:0002866 ISO     positive regulation of acute inflammatory response to antigenic stimulus GO:0002866 ISS     DNA repair GO:0006281 ISO     DNA repair GO:0006281 ISS     proteolysis GO:0006508 IEA     autophagy GO:0006914 IEA     inflammatory response GO:0006954 IEA     response to oxidative stress GO:0006979 IBA     response to oxidative stress GO:0006979 IMP     response to oxidative stress GO:0006979 ISO     response to oxidative stress GO:0006979 ISS     mitochondrion organization GO:0007005 ISO     mitochondrion organization GO:0007005 ISS     spermatogenesis GO:0007283 IEP     single fertilization GO:0007338 IEA     adult locomotory behavior GO:0008344 ISO     response to xenobiotic stimulus GO:0009410 IEP     methylglyoxal metabolic process GO:0009438 ISO     methylglyoxal metabolic process GO:0009438 ISO     methylglyoxal metabolic process GO:0009438 ISS     fertilization GO:0009566 TAS     detoxification of copper ion GO:0010273 ISO     detoxification of copper ion GO:0010273 ISS     positive regulation of gene expression GO:0010628 ISO     negative regulation of gene expression GO:0010629 ISO     negative regulation of smooth muscle cell migration GO:0014912 IDA     lactate biosynthetic process GO:0019249 ISO     removal of superoxide radicals GO:0019430 ISO     removal of superoxide radicals GO:0019430 ISS     insulin secretion GO:0030073 ISO     insulin secretion GO:0030073 ISS     protein repair GO:0030091 ISO     androgen receptor signaling pathway GO:0030521 ISO     androgen receptor signaling pathway GO:0030521 ISS     positive regulation of protein-containing complex assembly GO:0031334 ISO     positive regulation of protein-containing complex assembly GO:0031334 ISS     negative regulation of protein ubiquitination GO:0031397 ISO     negative regulation of protein ubiquitination GO:0031397 ISO     negative regulation of protein ubiquitination GO:0031397 ISS     negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435 ISO     regulation of TRAIL production GO:0032679 ISO     positive regulation of interleukin-8 production GO:0032757 ISO     positive regulation of interleukin-8 production GO:0032757 ISS     positive regulation of peptidyl-serine phosphorylation GO:0033138 ISO     negative regulation of protein sumoylation GO:0033234 ISO     negative regulation of protein sumoylation GO:0033234 ISS     positive regulation of NAD(P)H oxidase activity GO:0033864 ISO     positive regulation of NAD(P)H oxidase activity GO:0033864 ISS     cellular response to oxidative stress GO:0034599 ISO     cellular response to oxidative stress GO:0034599 ISS     cellular response to reactive oxygen species GO:0034614 ISO     cellular response to glyoxal GO:0036471 ISO     cellular response to glyoxal GO:0036471 ISS     negative regulation of protein catabolic process GO:0042177 ISO     response to hydrogen peroxide GO:0042542 ISO     glucose homeostasis GO:0042593 ISO     glucose homeostasis GO:0042593 ISS     hydrogen peroxide metabolic process GO:0042743 ISO     hydrogen peroxide metabolic process GO:0042743 ISO     regulation of neuron apoptotic process GO:0043523 ISO     regulation of neuron apoptotic process GO:0043523 ISS     negative regulation of neuron apoptotic process GO:0043524 ISO     negative regulation of neuron apoptotic process GO:0043524 ISS     positive regulation of transcription by RNA polymerase II GO:0045944 ISO     positive regulation of transcription by RNA polymerase II GO:0045944 ISO     positive regulation of transcription by RNA polymerase II GO:0045944 ISS     glycolate biosynthetic process GO:0046295 IBA     glycolate biosynthetic process GO:0046295 ISO     glycolate biosynthetic process GO:0046295 ISS     negative regulation of protein export from nucleus GO:0046826 ISO     negative regulation of protein export from nucleus GO:0046826 ISS     regulation of inflammatory response GO:0050727 ISO     regulation of inflammatory response GO:0050727 ISS     detoxification of mercury ion GO:0050787 ISO     protein stabilization GO:0050821 ISO     protein stabilization GO:0050821 ISO     protein stabilization GO:0050821 ISS     dopamine uptake involved in synaptic transmission GO:0051583 ISO     regulation of mitochondrial membrane potential GO:0051881 ISO     regulation of mitochondrial membrane potential GO:0051881 ISS     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO     membrane depolarization GO:0051899 ISO     membrane hyperpolarization GO:0060081 ISO     maternal process involved in female pregnancy GO:0060135 IEP     regulation of androgen receptor signaling pathway GO:0060765 ISO     regulation of androgen receptor signaling pathway GO:0060765 ISS     detoxification of hydrogen peroxide GO:0061691 ISO     detoxification of hydrogen peroxide GO:0061691 ISS     methylglyoxal catabolic process to lactate GO:0061727 ISO     methylglyoxal catabolic process to lactate GO:0061727 ISS     cellular response to hydrogen peroxide GO:0070301 ISO     detection of oxidative stress GO:0070994 ISO     cellular response to lipopolysaccharide GO:0071222 IEP     cellular response to hypoxia GO:0071456 IEP     guanine deglycation GO:0106044 ISO     guanine deglycation GO:0106044 ISS     guanine deglycation, methylglyoxal removal GO:0106045 ISO     guanine deglycation, methylglyoxal removal GO:0106045 ISS     guanine deglycation, glyoxal removal GO:0106046 ISO     guanine deglycation, glyoxal removal GO:0106046 ISS     cellular detoxification of aldehyde GO:0110095 ISO     cellular detoxification of aldehyde GO:0110095 ISS     cellular detoxification of methylglyoxal GO:0140041 ISO     cellular detoxification of methylglyoxal GO:0140041 ISS     positive regulation of protein localization to nucleus GO:1900182 ISO     positive regulation of protein localization to nucleus GO:1900182 ISS     regulation of synaptic vesicle endocytosis GO:1900242 ISO     negative regulation of protein acetylation GO:1901984 ISO     negative regulation of protein acetylation GO:1901984 ISS     negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 ISO     positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902177 ISO     negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 ISO     positive regulation of mitochondrial electron transport, NADH to ubiquinone GO:1902958 ISO     positive regulation of mitochondrial electron transport, NADH to ubiquinone GO:1902958 ISS     negative regulation of death-inducing signaling complex assembly GO:1903073 ISO     negative regulation of protein K48-linked deubiquitination GO:1903094 ISO     negative regulation of protein K48-linked deubiquitination GO:1903094 ISS     negative regulation of TRAIL-activated apoptotic signaling pathway GO:1903122 ISO     negative regulation of TRAIL-activated apoptotic signaling pathway GO:1903122 ISS     positive regulation of dopamine biosynthetic process GO:1903181 ISO     positive regulation of dopamine biosynthetic process GO:1903181 ISS     glyoxal metabolic process GO:1903189 IBA     glyoxal metabolic process GO:1903189 ISO     glyoxal catabolic process GO:1903190 IEA     positive regulation of L-dopa biosynthetic process GO:1903197 ISO     positive regulation of L-dopa biosynthetic process GO:1903197 ISS     regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1903376 ISO     negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1903377 ISO     negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1903377 ISS     negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway GO:1903384 ISO     negative regulation of reactive oxygen species biosynthetic process GO:1903427 ISO     negative regulation of reactive oxygen species biosynthetic process GO:1903427 ISS     positive regulation of reactive oxygen species biosynthetic process GO:1903428 ISO     negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide GO:1903751 ISO     negative regulation of vascular associated smooth muscle cell proliferation GO:1904706 IDA     negative regulation of NMDA glutamate receptor activity GO:1904782 IMP     negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway GO:1905259 ISO     positive regulation of fertilization GO:1905516 IMP     positive regulation of oxidative phosphorylation uncoupler activity GO:2000277 ISO     positive regulation of oxidative phosphorylation uncoupler activity GO:2000277 ISS     positive regulation of reactive oxygen species metabolic process GO:2000379 ISO     positive regulation of reactive oxygen species metabolic process GO:2000379 ISS     negative regulation of extrinsic apoptotic signaling pathway GO:2001237 ISO     negative regulation of extrinsic apoptotic signaling pathway GO:2001237 ISS Subcellular Localization     chromatin GO:0000785 ISO     nucleus GO:0005634 IBA     nucleus GO:0005634 ISO     nucleus GO:0005634 ISS     nucleoplasm GO:0005654 ISO     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 ISS     mitochondrion GO:0005739 IBA     mitochondrion GO:0005739 IDA     mitochondrion GO:0005739 ISO     mitochondrion GO:0005739 ISS     mitochondrial intermembrane space GO:0005758 ISO     mitochondrial matrix GO:0005759 ISO     endoplasmic reticulum GO:0005783 IDA     endoplasmic reticulum GO:0005783 ISO     cytosol GO:0005829 ISO     plasma membrane GO:0005886 IEA     synaptic vesicle GO:0008021 ISO     PML body GO:0016605 ISO     PML body GO:0016605 ISS     axon GO:0030424 IDA     neuron projection GO:0043005 ISO     cell body GO:0044297 ISO     membrane raft GO:0045121 IEA     perinuclear region of cytoplasm GO:0048471 ISO     sperm head GO:0061827 IDA     extracellular exosome GO:0070062 ISS