Gene description for Clta
Gene name clathrin, light chain A
Gene symbol Clta
Other names/aliases LCA1
LCA2
LCA3
Species Rattus norvegicus
 Database cross references - Clta
ExoCarta ExoCarta_83800
Vesiclepedia VP_83800
Entrez Gene 83800
UniProt P08081  
 Clta identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Clta
Molecular Function
    structural molecule activity GO:0005198 IEA
    protein binding GO:0005515 IPI
    clathrin heavy chain binding GO:0032050 IBA
    clathrin heavy chain binding GO:0032050 ISO
    peptide binding GO:0042277 IDA
    protein-containing complex binding GO:0044877 IPI
    GTPase binding GO:0051020 IPI
Biological Process
    intracellular protein transport GO:0006886 IEA
    endocytosis GO:0006897 IEP
    vesicle-mediated transport GO:0016192 IEA
    clathrin coat assembly GO:0048268 ISO
    synaptic vesicle endocytosis GO:0048488 EXP
    synaptic vesicle endocytosis GO:0048488 IDA
    synaptic vesicle endocytosis GO:0048488 IMP
    cell division GO:0051301 IEA
    clathrin-dependent endocytosis GO:0072583 IBA
Subcellular Localization
    spindle GO:0005819 IEA
    plasma membrane GO:0005886 IBA
    clathrin-coated pit GO:0005905 IDA
    clathrin coat GO:0030118 IDA
    clathrin coat GO:0030118 ISO
    clathrin vesicle coat GO:0030125 IBA
    clathrin vesicle coat GO:0030125 NAS
    clathrin coat of trans-Golgi network vesicle GO:0030130 IEA
    clathrin coat of coated pit GO:0030132 IEA
    clathrin coat of coated pit GO:0030132 NAS
    clathrin-coated vesicle GO:0030136 IDA
    clathrin-coated endocytic vesicle membrane GO:0030669 TAS
    synaptic vesicle membrane GO:0030672 IBA
    synaptic vesicle membrane GO:0030672 IDA
    synaptic vesicle membrane GO:0030672 IDA
    cytoplasmic vesicle GO:0031410 ISO
    clathrin complex GO:0071439 ISO
    presynaptic endocytic zone membrane GO:0098835 IDA
    postsynaptic endocytic zone GO:0098843 IDA
    postsynaptic endocytic zone GO:0098843 IMP
    postsynaptic endocytic zone GO:0098843 ISO
    glutamatergic synapse GO:0098978 ISO
    postsynaptic endocytic zone cytoplasmic component GO:0099631 IBA
 Experiment description of studies that identified Clta in exosomes
1
Experiment ID 35
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|CD81|CD63
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Clta
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Epn1  
Affinity Capture-Western Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
2 TNK2 10188
Reconstituted Complex Homo sapiens
3 Amph  
Affinity Capture-Western Rattus norvegicus
4 Park7 117287
Affinity Capture-MS Rattus norvegicus
5 Bin1  
Affinity Capture-Western Rattus norvegicus
6 Vcp 116643
Affinity Capture-Western Rattus norvegicus
7 STXBP5L  
Affinity Capture-MS Homo sapiens
8 Dab2 13132
Affinity Capture-Western Mus musculus
9 Itm2b 290364
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml
 Pathways in which Clta is involved
PathwayEvidenceSource
Adaptive Immune System IEA Reactome
Axon guidance IEA Reactome
Beta-catenin independent WNT signaling IEA Reactome
Cargo recognition for clathrin-mediated endocytosis IEA Reactome
Clathrin-mediated endocytosis IEA Reactome
Developmental Biology IEA Reactome
Formation of annular gap junctions IEA Reactome
Gap junction degradation IEA Reactome
Gap junction trafficking IEA Reactome
Gap junction trafficking and regulation IEA Reactome
Golgi Associated Vesicle Biogenesis IEA Reactome
Immune System IEA Reactome
L1CAM interactions IEA Reactome
LDL clearance IEA Reactome
Lysosome Vesicle Biogenesis IEA Reactome
Membrane Trafficking IEA Reactome
MHC class II antigen presentation IEA Reactome
Nervous system development IEA Reactome
PCP/CE pathway IEA Reactome
Plasma lipoprotein assembly, remodeling, and clearance IEA Reactome
Plasma lipoprotein clearance IEA Reactome
Recycling pathway of L1 IEA Reactome
Retrograde neurotrophin signalling IEA Reactome
Signal Transduction IEA Reactome
Signaling by NTRK1 (TRKA) IEA Reactome
Signaling by NTRKs IEA Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by WNT IEA Reactome
trans-Golgi Network Vesicle Budding IEA Reactome
Transport of small molecules IEA Reactome
Vesicle-mediated transport IEA Reactome
VLDLR internalisation and degradation IEA Reactome
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 IEA Reactome
WNT5A-dependent internalization of FZD4 IEA Reactome





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