Gene description for Phb
Gene name	prohibitin
Gene symbol	Phb
Other names/aliases	-
Species	Rattus norvegicus
Database cross references - Phb
ExoCarta	ExoCarta_25344
Vesiclepedia	VP_25344
Entrez Gene	25344
UniProt	P67779
Phb identified in exosomes derived from the following tissue/cell type
Adipocytes	25998041
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Phb

Molecular Function     complement component C3a binding GO:0001850 ISO     complement component C3b binding GO:0001851 ISO     transcription corepressor activity GO:0003714 ISO     enzyme binding GO:0019899 ISO     proteinase activated receptor binding GO:0031871 ISO     histone deacetylase binding GO:0042826 ISO     protein heterodimerization activity GO:0046982 ISO Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 ISO     negative regulation of transcription by RNA polymerase II GO:0000122 ISO     ovarian follicle development GO:0001541 IEP     ovarian follicle atresia GO:0001552 IEP     positive regulation of immunoglobulin production GO:0002639 ISO     positive regulation of immunoglobulin production GO:0002639 ISS     regulation of DNA-templated transcription GO:0006355 ISO     mitochondrion organization GO:0007005 IBA     mitochondrion organization GO:0007005 ISO     negative regulation of cell population proliferation GO:0008285 IMP     negative regulation of cell population proliferation GO:0008285 ISO     response to xenobiotic stimulus GO:0009410 IEP     positive regulation of gene expression GO:0010628 ISO     negative regulation of gene expression GO:0010629 IMP     negative regulation of transcription by competitive promoter binding GO:0010944 ISO     negative regulation of cell growth GO:0030308 ISO     animal organ regeneration GO:0031100 IEP     positive regulation of interleukin-17 production GO:0032740 ISO     positive regulation of interleukin-17 production GO:0032740 ISS     response to cytokine GO:0034097 IEP     response to immobilization stress GO:0035902 IEP     RIG-I signaling pathway GO:0039529 ISO     epigenetic regulation of gene expression GO:0040029 ISO     B cell activation GO:0042113 ISO     B cell activation GO:0042113 ISS     negative regulation of protein catabolic process GO:0042177 ISO     negative regulation of apoptotic process GO:0043066 IMP     response to peptide hormone GO:0043434 IEP     positive regulation of neuron apoptotic process GO:0043525 ISO     modulation by host of viral RNA genome replication GO:0044830 ISO     response to ethanol GO:0045471 IEP     positive regulation of G protein-coupled receptor signaling pathway GO:0045745 ISO     negative regulation of DNA-templated transcription GO:0045892 ISO     positive regulation of DNA-templated transcription GO:0045893 ISO     positive regulation of complement activation GO:0045917 ISO     symbiont entry into host cell GO:0046718 ISO     positive regulation of smooth muscle cell proliferation GO:0048661 IMP     protein stabilization GO:0050821 ISO     progesterone receptor signaling pathway GO:0050847 ISO     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IMP     negative regulation of androgen receptor signaling pathway GO:0060766 ISO     negative regulation of ERK1 and ERK2 cascade GO:0070373 ISO     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO     cellular response to interleukin-6 GO:0071354 ISO     DNA biosynthetic process GO:0071897 ISO     T-helper 17 type immune response GO:0072538 ISO     T-helper 17 type immune response GO:0072538 ISS     antiviral innate immune response GO:0140374 ISO     positive regulation of non-canonical NF-kappaB signal transduction GO:1901224 ISO     positive regulation of non-canonical NF-kappaB signal transduction GO:1901224 ISS     negative regulation of glucocorticoid receptor signaling pathway GO:2000323 ISO Subcellular Localization     nucleus GO:0005634 ISO     nucleoplasm GO:0005654 ISO     cytoplasm GO:0005737 ISO     mitochondrion GO:0005739 IBA     mitochondrion GO:0005739 ISO     mitochondrial outer membrane GO:0005741 IDA     mitochondrial inner membrane GO:0005743 ISO     early endosome GO:0005769 ISO     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISS     cell surface GO:0009986 ISO     cell surface GO:0009986 ISS     postsynaptic density GO:0014069 EXP     postsynaptic density GO:0014069 IDA     mitochondrial prohibitin complex GO:0035632 ISO     mitochondrial prohibitin complex GO:0035632 ISS     synapse GO:0045202 IDA     exocytic vesicle GO:0070382 ISO     extrinsic component of presynaptic active zone membrane GO:0098891 EXP     extrinsic component of presynaptic active zone membrane GO:0098891 IDA     glutamatergic synapse GO:0098978 EXP     glutamatergic synapse GO:0098978 IDA     GABA-ergic synapse GO:0098982 EXP     GABA-ergic synapse GO:0098982 IDA