Gene description for Sept7
Gene name septin 7
Gene symbol Sept7
Other names/aliases Cdc10
Species Rattus norvegicus
 Database cross references - Sept7
ExoCarta ExoCarta_64551
Vesiclepedia VP_64551
Entrez Gene 64551
UniProt Q9WVC0  
 Sept7 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Sept7
Molecular Function
    GTPase activity GO:0003924 IBA
    GTP binding GO:0005525 IEA
    identical protein binding GO:0042802 ISO
    molecular adaptor activity GO:0060090 IBA
    structural constituent of postsynapse GO:0099186 EXP
    structural constituent of postsynapse GO:0099186 IDA
    structural constituent of postsynapse GO:0099186 IMP
Biological Process
    mitotic cytokinesis GO:0000281 ISO
    spermatogenesis GO:0007283 IEA
    protein localization GO:0008104 IBA
    vesicle-mediated transport GO:0016192 ISO
    regulation of embryonic cell shape GO:0016476 ISS
    cortical cytoskeleton organization GO:0030865 ISO
    pseudopodium retraction GO:0031270 ISO
    D-glucose import GO:0046323 ISO
    collateral sprouting GO:0048668 ISO
    cell division GO:0051301 IEA
    cilium assembly GO:0060271 ISS
    dendritic spine morphogenesis GO:0060997 ISO
    cytoskeleton-dependent cytokinesis GO:0061640 IBA
    postsynapse organization GO:0099173 IDA
    postsynapse organization GO:0099173 IMP
    positive regulation of non-motile cilium assembly GO:1902857 ISO
Subcellular Localization
    kinetochore GO:0000776 IEA
    stress fiber GO:0001725 ISO
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    spindle GO:0005819 IEA
    plasma membrane GO:0005886 ISO
    cilium GO:0005929 IEA
    axoneme GO:0005930 ISO
    axoneme GO:0005930 ISS
    cell cortex GO:0005938 ISO
    septin ring GO:0005940 IBA
    septin ring GO:0005940 ISO
    microtubule cytoskeleton GO:0015630 IBA
    membrane GO:0016020 ISO
    apical plasma membrane GO:0016324 ISS
    midbody GO:0030496 IEA
    septin complex GO:0031105 IBA
    septin complex GO:0031105 IEA
    septin complex GO:0031105 ISO
    septin complex GO:0031105 ISS
    vesicle GO:0031982 ISO
    cell division site GO:0032153 IBA
    cleavage furrow GO:0032154 IEA
    septin cytoskeleton GO:0032156 ISO
    septin filament array GO:0032160 ISO
    protein-containing complex GO:0032991 ISO
    presynaptic membrane GO:0042734 ISO
    neuron projection GO:0043005 ISO
    neuronal cell body GO:0043025 ISO
    axon terminus GO:0043679 ISO
    synapse GO:0045202 ISO
    sperm annulus GO:0097227 ISO
    non-motile cilium GO:0097730 ISO
    glutamatergic synapse GO:0098978 EXP
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IMP
    postsynaptic septin cytoskeleton GO:0150050 EXP
    postsynaptic septin cytoskeleton GO:0150050 IDA
    postsynaptic septin cytoskeleton GO:0150050 IMP
 Experiment description of studies that identified Sept7 in exosomes
1
Experiment ID 95
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 96
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 97
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
4
Experiment ID 98
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Sept7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Snca  
Affinity Capture-MS Rattus norvegicus
2 Itm2b 290364
Affinity Capture-MS Rattus norvegicus
3 Park7 117287
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml
 Pathways in which Sept7 is involved
PathwayEvidenceSource
MAPK family signaling cascades IEA Reactome
MAPK6/MAPK4 signaling IEA Reactome
Signal Transduction IEA Reactome





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