Gene description for Actc1
Gene name actin, alpha, cardiac muscle 1
Gene symbol Actc1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Actc1
ExoCarta ExoCarta_29275
Vesiclepedia VP_29275
Entrez Gene 29275
UniProt P68035  
 Actc1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Actc1
Molecular Function
    ATPase activity GO:0016887 ISO
    myosin binding GO:0017022 ISO
    ATP binding GO:0005524 ISO
    protein binding GO:0005515 IPI
Biological Process
    actin-mediated cell contraction GO:0070252 ISO
    cardiac muscle contraction GO:0060048 IDA
    negative regulation of apoptotic process GO:0043066 ISO
    positive regulation of gene expression GO:0010628 ISS
    metabolic process GO:0008152 ISO
    heart contraction GO:0060047 ISO
    mesenchyme migration GO:0090131 ISS
    skeletal muscle thin filament assembly GO:0030240 ISO
    cardiac muscle tissue morphogenesis GO:0055008 ISO
    actin-myosin filament sliding GO:0033275 ISO
    actomyosin structure organization GO:0031032 ISO
    response to ethanol GO:0045471 IEP
    cardiac myofibril assembly GO:0055003 ISO
    response to drug GO:0042493 IEP
    actin filament-based movement GO:0030048 ISO
Subcellular Localization
    filopodium GO:0030175 ISS
    extracellular exosome GO:0070062 ISO
    actin filament GO:0005884 ISO
    membrane GO:0016020 ISO
    blood microparticle GO:0072562 ISO
    focal adhesion GO:0005925 ISO
    actomyosin, actin portion GO:0042643 ISO
    I band GO:0031674 ISO
    lamellipodium GO:0030027 ISS
    cytoplasm GO:0005737 ISS
    extracellular space GO:0005615 ISO
    cell body GO:0044297 ISS
    sarcomere GO:0030017 ISO
 Experiment description of studies that identified Actc1 in exosomes
1
Experiment ID 96
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 97
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Actc1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Actc1 is involved
PathwayEvidenceSource
Striated Muscle Contraction IEA Reactome





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