Gene description for Npm1
Gene name	nucleophosmin (nucleolar phosphoprotein B23, numatrin)
Gene symbol	Npm1
Other names/aliases	B23NP
Species	Rattus norvegicus
Database cross references - Npm1
ExoCarta	ExoCarta_25498
Vesiclepedia	VP_25498
Entrez Gene	25498
UniProt	P13084
Npm1 identified in exosomes derived from the following tissue/cell type
Reticulocytes	21828046

Gene ontology annotations for Npm1

Molecular Function     core promoter sequence-specific DNA binding GO:0001046 ISO     p53 binding GO:0002039 IPI     DNA binding GO:0003677 IDA     chromatin binding GO:0003682 IBA     transcription coactivator activity GO:0003713 ISO     RNA binding GO:0003723 IBA     RNA binding GO:0003723 IEA     RNA binding GO:0003723 ISO     protein kinase inhibitor activity GO:0004860 ISO     protein kinase inhibitor activity GO:0004860 ISS     protein binding GO:0005515 IPI     ATP binding GO:0005524 IMP     phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547 IPI     rRNA binding GO:0019843 IEA     rRNA binding GO:0019843 ISO     enzyme binding GO:0019899 IDA     enzyme binding GO:0019899 IPI     protein kinase binding GO:0019901 ISO     Tat protein binding GO:0030957 ISO     histone binding GO:0042393 IBA     histone binding GO:0042393 ISO     identical protein binding GO:0042802 IEA     identical protein binding GO:0042802 IPI     identical protein binding GO:0042802 ISO     protein homodimerization activity GO:0042803 ISO     ribosomal large subunit binding GO:0043023 ISO     ribosomal small subunit binding GO:0043024 ISO     protein kinase B binding GO:0043422 IDA     NF-kappaB binding GO:0051059 ISO     NF-kappaB binding GO:0051059 ISS     unfolded protein binding GO:0051082 ISO     unfolded protein binding GO:0051082 ISS     molecular adaptor activity GO:0060090 ISO     DNA-binding transcription factor binding GO:0140297 ISO Biological Process     ribosomal large subunit export from nucleus GO:0000055 IBA     ribosomal large subunit export from nucleus GO:0000055 IEA     ribosomal large subunit export from nucleus GO:0000055 ISO     ribosomal small subunit export from nucleus GO:0000056 IBA     ribosomal small subunit export from nucleus GO:0000056 IEA     ribosomal small subunit export from nucleus GO:0000056 ISO     cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000448 IDA     regulation of cell growth GO:0001558 IEA     regulation of cell growth GO:0001558 ISO     cardiac muscle hypertrophy GO:0003300 IEP     DNA repair GO:0006281 ISO     DNA repair GO:0006281 ISS     nucleosome assembly GO:0006334 ISO     chromatin remodeling GO:0006338 IBA     protein import into nucleus GO:0006606 ISO     cell volume homeostasis GO:0006884 IEA     cell volume homeostasis GO:0006884 ISO     nucleocytoplasmic transport GO:0006913 ISO     nucleocytoplasmic transport GO:0006913 ISO     centrosome cycle GO:0007098 ISO     centrosome cycle GO:0007098 ISS     protein localization GO:0008104 IEA     protein localization GO:0008104 ISO     protein localization GO:0008104 ISO     positive regulation of cell population proliferation GO:0008284 IEA     positive regulation of cell population proliferation GO:0008284 ISO     positive regulation of cell population proliferation GO:0008284 ISO     positive regulation of cell population proliferation GO:0008284 ISS     negative regulation of cell population proliferation GO:0008285 ISO     negative regulation of cell population proliferation GO:0008285 ISS     rRNA transcription GO:0009303 IMP     post-transcriptional regulation of gene expression GO:0010608 IEA     post-transcriptional regulation of gene expression GO:0010608 ISO     negative regulation of gene expression GO:0010629 ISO     negative regulation of cardiac muscle cell apoptotic process GO:0010667 IMP     regulation of centrosome duplication GO:0010824 IBA     regulation of centrosome duplication GO:0010824 ISO     positive regulation of centrosome duplication GO:0010825 IEA     positive regulation of centrosome duplication GO:0010825 ISO     negative regulation of centrosome duplication GO:0010826 ISO     macrophage differentiation GO:0030225 ISO     positive regulation of protein ubiquitination GO:0031398 IEA     positive regulation of protein ubiquitination GO:0031398 ISO     regulation of protein stability GO:0031647 ISO     protein destabilization GO:0031648 ISO     regulation of endodeoxyribonuclease activity GO:0032071 ISO     regulation of endodeoxyribonuclease activity GO:0032071 ISS     cellular response to UV GO:0034644 ISO     ribosomal large subunit biogenesis GO:0042273 IBA     ribosomal large subunit biogenesis GO:0042273 IEA     ribosomal large subunit biogenesis GO:0042273 ISO     ribosomal small subunit biogenesis GO:0042274 IBA     ribosomal small subunit biogenesis GO:0042274 IEA     ribosomal small subunit biogenesis GO:0042274 ISO     negative regulation of apoptotic process GO:0043066 IEA     negative regulation of apoptotic process GO:0043066 ISO     negative regulation of apoptotic process GO:0043066 ISO     negative regulation of apoptotic process GO:0043066 ISS     positive regulation of catalytic activity GO:0043085 IDA     regulation of DNA damage response, signal transduction by p53 class mediator GO:0043516 IEA     regulation of DNA damage response, signal transduction by p53 class mediator GO:0043516 ISO     regulation of neuron apoptotic process GO:0043523 IMP     negative regulation of neuron apoptotic process GO:0043524 IMP     negative regulation of protein kinase activity by regulation of protein phosphorylation GO:0044387 ISO     negative regulation of protein kinase activity by regulation of protein phosphorylation GO:0044387 ISS     positive regulation of translation GO:0045727 ISO     positive regulation of translation GO:0045727 ISS     positive regulation of DNA replication GO:0045740 IDA     positive regulation of protein kinase activity GO:0045860 ISO     positive regulation of DNA-templated transcription GO:0045893 ISO     positive regulation of DNA-templated transcription GO:0045893 ISS     positive regulation of transcription by RNA polymerase II GO:0045944 IBA     positive regulation of transcription by RNA polymerase II GO:0045944 IEA     positive regulation of transcription by RNA polymerase II GO:0045944 ISO     positive regulation of transcription by RNA polymerase II GO:0045944 ISS     regulation of centriole replication GO:0046599 ISO     regulation of centriole replication GO:0046599 ISS     negative regulation of mRNA splicing, via spliceosome GO:0048025 IEA     negative regulation of mRNA splicing, via spliceosome GO:0048025 ISO     negative regulation of epithelial cell proliferation GO:0050680 IMP     protein stabilization GO:0050821 IEA     protein stabilization GO:0050821 ISO     protein stabilization GO:0050821 ISO     positive regulation of DNA metabolic process GO:0051054 IDA     positive regulation of NF-kappaB transcription factor activity GO:0051092 ISO     regulation of cell cycle GO:0051726 ISO     regulation of endoribonuclease activity GO:0060699 ISO     regulation of endoribonuclease activity GO:0060699 ISS     regulation of eIF2 alpha phosphorylation by dsRNA GO:0060735 ISO     regulation of eIF2 alpha phosphorylation by dsRNA GO:0060735 ISS     cellular response to testosterone stimulus GO:0071394 IEP     cellular response to hypoxia GO:0071456 IEP     cellular senescence GO:0090398 ISO     cellular senescence GO:0090398 ISS     liver regeneration GO:0097421 IEP     positive regulation of DNA-directed DNA polymerase activity GO:1900264 IDA     regulation of mRNA stability involved in cellular response to UV GO:1902629 ISO     positive regulation of cell cycle G2/M phase transition GO:1902751 ISO     positive regulation of cell cycle G2/M phase transition GO:1902751 ISS     positive regulation of protein localization to nucleolus GO:1904751 IEA     positive regulation of protein localization to nucleolus GO:1904751 ISO     positive regulation of protein localization to nucleolus GO:1904751 ISO Subcellular Localization     granular component GO:0001652 IEA     granular component GO:0001652 ISO     nucleus GO:0005634 ISO     nucleus GO:0005634 ISO     nucleus GO:0005634 ISS     nucleoplasm GO:0005654 IBA     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 IEA     nucleoplasm GO:0005654 ISO     nucleolus GO:0005730 IBA     nucleolus GO:0005730 IEA     nucleolus GO:0005730 ISO     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IEA     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 ISS     centrosome GO:0005813 IBA     centrosome GO:0005813 IEA     centrosome GO:0005813 ISO     centrosome GO:0005813 ISS     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     large ribosomal subunit GO:0015934 IEA     large ribosomal subunit GO:0015934 ISO     small ribosomal subunit GO:0015935 IEA     small ribosomal subunit GO:0015935 ISO     nuclear matrix GO:0016363 IDA     nuclear speck GO:0016607 IEA     nuclear speck GO:0016607 ISO     spindle pole centrosome GO:0031616 ISO     protein-containing complex GO:0032991 ISO     protein-DNA complex GO:0032993 ISO     ribonucleoprotein complex GO:1990904 IBA     ribonucleoprotein complex GO:1990904 ISO