Gene description for Calr
Gene name	calreticulin
Gene symbol	Calr
Other names/aliases	-
Species	Rattus norvegicus
Database cross references - Calr
ExoCarta	ExoCarta_64202
Vesiclepedia	VP_64202
Entrez Gene	64202
UniProt	P18418
Calr identified in exosomes derived from the following tissue/cell type
Adipocytes	25998041
Hepatocytes	19367702
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Calr

Molecular Function     complement component C1q complex binding GO:0001849 ISO     mRNA binding GO:0003729 IDA     mRNA binding GO:0003729 ISO     nuclear export signal receptor activity GO:0005049 ISO     integrin binding GO:0005178 ISO     iron ion binding GO:0005506 IDA     calcium ion binding GO:0005509 IBA     calcium ion binding GO:0005509 IDA     calcium ion binding GO:0005509 IEA     calcium ion binding GO:0005509 ISO     protein binding GO:0005515 IPI     carbohydrate binding GO:0030246 IEA     carbohydrate binding GO:0030246 ISO     ubiquitin protein ligase binding GO:0031625 ISO     peptide binding GO:0042277 IDA     hormone binding GO:0042562 IPI     nuclear androgen receptor binding GO:0050681 ISO     unfolded protein binding GO:0051082 IEA     molecular sequestering activity GO:0140313 ISO Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 ISO     peptide antigen assembly with MHC class I protein complex GO:0002502 ISO     protein folding GO:0006457 IBA     protein folding GO:0006457 IEA     protein folding GO:0006457 TAS     protein export from nucleus GO:0006611 ISO     spermatogenesis GO:0007283 IEP     positive regulation of cell population proliferation GO:0008284 ISO     response to xenobiotic stimulus GO:0009410 IEP     positive regulation of endothelial cell migration GO:0010595 ISO     positive regulation of gene expression GO:0010628 ISO     negative regulation of translation GO:0017148 ISO     cortical actin cytoskeleton organization GO:0030866 ISO     response to estradiol GO:0032355 IEP     negative regulation of intracellular steroid hormone receptor signaling pathway GO:0033144 ISO     response to testosterone GO:0033574 IEP     protein localization to nucleus GO:0034504 ISO     ERAD pathway GO:0036503 IBA     regulation of meiotic nuclear division GO:0040020 ISO     negative regulation of neuron differentiation GO:0045665 ISO     positive regulation of cell cycle GO:0045787 ISO     positive regulation of cell cycle GO:0045787 ISO     negative regulation of DNA-templated transcription GO:0045892 ISO     negative regulation of retinoic acid receptor signaling pathway GO:0048387 ISO     positive regulation of phagocytosis GO:0050766 ISO     protein stabilization GO:0050821 ISO     protein stabilization GO:0050821 ISS     cardiac muscle cell differentiation GO:0055007 IEP     cellular response to electrical stimulus GO:0071257 IEP     cellular response to lithium ion GO:0071285 IEP     cellular senescence GO:0090398 ISO     cellular response to virus GO:0098586 IEP     positive regulation of substrate adhesion-dependent cell spreading GO:1900026 ISO     negative regulation of trophoblast cell migration GO:1901164 ISO     positive regulation of non-canonical NF-kappaB signal transduction GO:1901224 ISO     response to peptide GO:1901652 IEP     response to glycoside GO:1903416 IEP     response to biphenyl GO:1904614 IEP     positive regulation of dendritic cell chemotaxis GO:2000510 ISO Subcellular Localization     acrosomal vesicle GO:0001669 IDA     extracellular region GO:0005576 IEA     extracellular space GO:0005615 IDA     extracellular space GO:0005615 ISO     nucleus GO:0005634 ISO     nuclear envelope GO:0005635 IDA     nuclear envelope GO:0005635 ISO     cytoplasm GO:0005737 ISO     mitochondrion GO:0005739 IDA     endoplasmic reticulum GO:0005783 IDA     endoplasmic reticulum GO:0005783 IDA     endoplasmic reticulum GO:0005783 ISO     endoplasmic reticulum lumen GO:0005788 ISO     endoplasmic reticulum membrane GO:0005789 IBA     smooth endoplasmic reticulum GO:0005790 IDA     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     ribosome GO:0005840 ISO     external side of plasma membrane GO:0009897 ISO     cell surface GO:0009986 IDA     cell surface GO:0009986 IEA     membrane GO:0016020 ISO     sarcoplasmic reticulum GO:0016529 IDA     protein-containing complex GO:0032991 IDA     sarcoplasmic reticulum lumen GO:0033018 IEA     MHC class I peptide loading complex GO:0042824 ISO     cytolytic granule GO:0044194 IEA     endoplasmic reticulum quality control compartment GO:0044322 ISO     perinuclear region of cytoplasm GO:0048471 IDA     perinuclear region of cytoplasm GO:0048471 ISO     cortical granule GO:0060473 IEA     cortical granule GO:0060473 ISS     collagen-containing extracellular matrix GO:0062023 IDA     postsynapse GO:0098794 IDA     glutamatergic synapse GO:0098978 IDA