Gene description for Acta1
Gene name actin, alpha 1, skeletal muscle
Gene symbol Acta1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Acta1
ExoCarta ExoCarta_29437
Entrez Gene 29437
UniProt P68136  
 Acta1 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Acta1
Molecular Function
    ATP binding GO:0005524 IEA
Biological Process
    response to steroid hormone GO:0048545 IEP
    skeletal muscle thin filament assembly GO:0030240 ISS
    cell growth GO:0016049 IEP
    response to extracellular stimulus GO:0009991 IEP
    positive regulation of gene expression GO:0010628 ISS
    response to lithium ion GO:0010226 IEP
    skeletal muscle fiber development GO:0048741 ISS
    response to mechanical stimulus GO:0009612 IEP
    mesenchyme migration GO:0090131 ISS
    skeletal muscle fiber adaptation GO:0043503 IEP
Subcellular Localization
    cytoplasm GO:0005737 ISS
    stress fiber GO:0001725 ISS
    lamellipodium GO:0030027 ISS
    blood microparticle GO:0072562 ISO
    striated muscle thin filament GO:0005865 ISS
    actin filament GO:0005884 ISS
    sarcomere GO:0030017 ISO
    extracellular space GO:0005615 ISO
    cell body GO:0044297 ISS
    filopodium GO:0030175 ISS
    extracellular exosome GO:0070062 ISO
    cellular_component GO:0005575 ND
    actin cytoskeleton GO:0015629 ISO
 Experiment description of studies that identified Acta1 in exosomes
1
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Acta1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Acta1 is involved
PathwayEvidenceSource
Striated Muscle Contraction IEA Reactome





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