Gene description for Acta1
Gene name actin, alpha 1, skeletal muscle
Gene symbol Acta1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Acta1
ExoCarta ExoCarta_29437
Vesiclepedia VP_29437
Entrez Gene 29437
UniProt P68136  
 Acta1 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Acta1
Molecular Function
    ATP binding GO:0005524 IEA
    hydrolase activity GO:0016787 IEA
    protein kinase binding GO:0019901 IEA
Biological Process
    regulation of blood pressure GO:0008217 IEA
    response to mechanical stimulus GO:0009612 IEP
    response to virus GO:0009615 IEA
    positive regulation of gene expression GO:0010628 ISS
    vascular associated smooth muscle contraction GO:0014829 IEA
    skeletal muscle thin filament assembly GO:0030240 IBA
    skeletal muscle thin filament assembly GO:0030240 ISO
    skeletal muscle thin filament assembly GO:0030240 ISS
    cellular response to potassium ion GO:0035865 IEP
    skeletal muscle fiber adaptation GO:0043503 IEP
    response to steroid hormone GO:0048545 IEP
    skeletal muscle fiber development GO:0048741 ISO
    skeletal muscle fiber development GO:0048741 ISS
    glomerular mesangial cell development GO:0072144 IEA
    mesenchyme migration GO:0090131 ISS
Subcellular Localization
    stress fiber GO:0001725 IBA
    stress fiber GO:0001725 ISO
    stress fiber GO:0001725 ISS
    cytoplasm GO:0005737 ISS
    striated muscle thin filament GO:0005865 IBA
    striated muscle thin filament GO:0005865 ISO
    striated muscle thin filament GO:0005865 ISS
    actin filament GO:0005884 IBA
    actin filament GO:0005884 ISO
    actin filament GO:0005884 ISS
    actin cytoskeleton GO:0015629 IBA
    actin cytoskeleton GO:0015629 IEA
    actin cytoskeleton GO:0015629 ISO
    sarcomere GO:0030017 ISO
    lamellipodium GO:0030027 ISS
    filopodium GO:0030175 ISS
    smooth muscle contractile fiber GO:0030485 IEA
    motile cilium GO:0031514 IEA
    protein-containing complex GO:0032991 IEA
    cell body GO:0044297 ISS
 Experiment description of studies that identified Acta1 in exosomes
1
Experiment ID 225
MISEV standards
EM
Biophysical techniques
GAPDH|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Acta1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Snca  
Affinity Capture-MS Rattus norvegicus
2 Sumo3  
Affinity Capture-MS Rattus norvegicus
3 Gja1  
Affinity Capture-MS Rattus norvegicus
4 Park7 117287
Affinity Capture-MS Rattus norvegicus
5 Cnn1  
FRET Rattus norvegicus
View the network image/svg+xml
 Pathways in which Acta1 is involved
PathwayEvidenceSource
Muscle contraction IEA Reactome
Striated Muscle Contraction IEA Reactome





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