Gene description for Slc2a4
Gene name solute carrier family 2 (facilitated glucose transporter), member 4
Gene symbol Slc2a4
Other names/aliases Glut4
Species Rattus norvegicus
 Database cross references - Slc2a4
ExoCarta ExoCarta_25139
Entrez Gene 25139
UniProt P19357  
 Slc2a4 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Slc2a4
Molecular Function
    glucose transmembrane transporter activity GO:0005355 ISO
    sugar:proton symporter activity GO:0005351 IBA
    D-glucose transmembrane transporter activity GO:0055056 IDA
    protein binding GO:0005515 IPI
Biological Process
    cellular response to hypoxia GO:0071456 IDA
    response to ethanol GO:0045471 IEP
    brown fat cell differentiation GO:0050873 ISO
    glucose import GO:0046323 IBA
    glucose homeostasis GO:0042593 ISO
    cellular response to osmotic stress GO:0071470 ISO
    amylopectin biosynthetic process GO:0010021 ISO
    cellular response to insulin stimulus GO:0032869 ISS
    glucose transport GO:0015758 ISO
    hexose transmembrane transport GO:0035428 ISO
    proton transport GO:0015992 IBA
Subcellular Localization
    cytoplasmic vesicle membrane GO:0030659 ISO
    endosome GO:0005768 ISO
    multivesicular body GO:0005771 IDA
    endomembrane system GO:0012505 ISS
    trans-Golgi network transport vesicle GO:0030140 ISO
    external side of plasma membrane GO:0009897 ISO
    clathrin-coated vesicle GO:0030136 ISO
    cytosol GO:0005829 ISO
    integral component of plasma membrane GO:0005887 ISO
    insulin-responsive compartment GO:0032593 ISO
    integral component of membrane GO:0016021 ISO
    cell surface GO:0009986 IDA
    extracellular exosome GO:0070062 ISO
    coated pit GO:0005905 IDA
    vesicle membrane GO:0012506 ISO
    plasma membrane GO:0005886 ISO
    membrane GO:0016020 ISO
    membrane raft GO:0045121 ISO
    intracellular membrane-bounded organelle GO:0043231 IDA
    perinuclear region of cytoplasm GO:0048471 ISO
    vesicle GO:0031982 IDA
    T-tubule GO:0030315 IDA
    sarcolemma GO:0042383 ISO
 Experiment description of studies that identified Slc2a4 in exosomes
1
Experiment ID 90
ISEV standards
EM
EV Biophysical techniques
HSC70|HSP90|TSG101
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 94
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 96
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
4
Experiment ID 97
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Slc2a4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ehd2 361512
Affinity Capture-Western Rattus norvegicus
View the network image/svg+xml



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