Gene description for CADM2
Gene name cell adhesion molecule 2
Gene symbol CADM2
Other names/aliases IGSF4D
NECL3
Necl-3
SynCAM 2
synCAM2
Species Homo sapiens
 Database cross references - CADM2
ExoCarta ExoCarta_253559
Vesiclepedia VP_253559
Entrez Gene 253559
HGNC 29849
MIM 609938
UniProt Q8N3J6  
 CADM2 identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for CADM2
Biological Process
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IBA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    axon GO:0030424 IEA
    neuronal cell body membrane GO:0032809 IBA
    synapse GO:0045202 IEA
 Experiment description of studies that identified CADM2 in sEVs
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for CADM2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TP53 7157
Affinity Capture-MS Homo sapiens
2 NUFIP1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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