Gene description for Cav1
Gene name caveolin 1, caveolae protein
Gene symbol Cav1
Other names/aliases Cav
Species Rattus norvegicus
 Database cross references - Cav1
ExoCarta ExoCarta_25404
Vesiclepedia VP_25404
Entrez Gene 25404
 Cav1 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Cav1
Molecular Function
    SNARE binding GO:0000149 IMP
    signaling receptor binding GO:0005102 IEA
    signaling receptor binding GO:0005102 ISO
    protein binding GO:0005515 IPI
    oxysterol binding GO:0008142 IEA
    oxysterol binding GO:0008142 ISO
    oxysterol binding GO:0008142 ISS
    peptidase activator activity GO:0016504 IEA
    peptidase activator activity GO:0016504 ISO
    enzyme binding GO:0019899 ISO
    kinase binding GO:0019900 IPI
    protein kinase binding GO:0019901 IBA
    protein kinase binding GO:0019901 IEA
    protein kinase binding GO:0019901 ISO
    syntaxin binding GO:0019905 IMP
    protein tyrosine kinase inhibitor activity GO:0030292 IEA
    protein tyrosine kinase inhibitor activity GO:0030292 ISO
    protein-macromolecule adaptor activity GO:0030674 IEA
    protein-macromolecule adaptor activity GO:0030674 ISO
    small GTPase binding GO:0031267 IEA
    small GTPase binding GO:0031267 ISO
    receptor serine/threonine kinase binding GO:0033612 IPI
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    transmembrane transporter binding GO:0044325 IBA
    transmembrane transporter binding GO:0044325 IEA
    transmembrane transporter binding GO:0044325 IPI
    transmembrane transporter binding GO:0044325 ISO
    protein-containing complex binding GO:0044877 IEA
    protein-containing complex binding GO:0044877 ISO
    protein heterodimerization activity GO:0046982 IEA
    protein heterodimerization activity GO:0046982 ISO
    nitric-oxide synthase binding GO:0050998 IEA
    nitric-oxide synthase binding GO:0050998 IPI
    nitric-oxide synthase binding GO:0050998 ISO
    ATPase binding GO:0051117 IEA
    ATPase binding GO:0051117 ISO
    molecular adaptor activity GO:0060090 IBA
    molecular adaptor activity GO:0060090 ISO
    inward rectifier potassium channel inhibitor activity GO:0070320 IEA
    inward rectifier potassium channel inhibitor activity GO:0070320 ISO
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IEA
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    negative regulation of transcription by RNA polymerase II GO:0000122 ISS
    MAPK cascade GO:0000165 IEA
    MAPK cascade GO:0000165 ISO
    angiogenesis GO:0001525 IEA
    angiogenesis GO:0001525 ISO
    vasculogenesis GO:0001570 IEA
    vasculogenesis GO:0001570 ISO
    response to hypoxia GO:0001666 IEA
    response to hypoxia GO:0001666 ISO
    endothelial cell proliferation GO:0001935 IEA
    endothelial cell proliferation GO:0001935 ISO
    negative regulation of endothelial cell proliferation GO:0001937 IBA
    negative regulation of endothelial cell proliferation GO:0001937 IEA
    negative regulation of endothelial cell proliferation GO:0001937 IMP
    negative regulation of endothelial cell proliferation GO:0001937 ISO
    positive regulation of endothelial cell proliferation GO:0001938 IMP
    negative regulation of cytokine-mediated signaling pathway GO:0001960 IEA
    negative regulation of cytokine-mediated signaling pathway GO:0001960 ISO
    regulation of the force of heart contraction GO:0002026 ISO
    glandular epithelial cell differentiation GO:0002067 IEA
    glandular epithelial cell differentiation GO:0002067 ISO
    response to ischemia GO:0002931 IEA
    response to ischemia GO:0002931 ISO
    regulation of the force of heart contraction by chemical signal GO:0003057 IEA
    regulation of the force of heart contraction by chemical signal GO:0003057 ISO
    triglyceride metabolic process GO:0006641 IEA
    triglyceride metabolic process GO:0006641 ISO
    nitric oxide biosynthetic process GO:0006809 IEA
    nitric oxide biosynthetic process GO:0006809 ISO
    calcium ion transport GO:0006816 IEA
    calcium ion transport GO:0006816 ISO
    intracellular calcium ion homeostasis GO:0006874 IMP
    intracellular calcium ion homeostasis GO:0006874 ISO
    regulation of smooth muscle contraction GO:0006940 IEA
    regulation of smooth muscle contraction GO:0006940 ISO
    tyrosine phosphorylation of STAT protein GO:0007260 ISO
    skeletal muscle tissue development GO:0007519 IEA
    skeletal muscle tissue development GO:0007519 ISO
    response to nutrient GO:0007584 IEP
    lactation GO:0007595 IEA
    lactation GO:0007595 ISO
    protein localization GO:0008104 ISO
    cell population proliferation GO:0008283 ISO
    negative regulation of cell population proliferation GO:0008285 ISO
    cellular response to starvation GO:0009267 ISO
    response to xenobiotic stimulus GO:0009410 IEP
    response to mechanical stimulus GO:0009612 IMP
    response to bacterium GO:0009617 IEA
    response to bacterium GO:0009617 ISO
    positive regulation of signal transduction GO:0009967 IMP
    negative regulation of signal transduction GO:0009968 ISO
    response to gamma radiation GO:0010332 IEP
    positive regulation of calcium ion transport into cytosol GO:0010524 IEA
    positive regulation of calcium ion transport into cytosol GO:0010524 ISO
    post-transcriptional regulation of gene expression GO:0010608 IEA
    post-transcriptional regulation of gene expression GO:0010608 ISO
    positive regulation of gene expression GO:0010628 IEA
    positive regulation of gene expression GO:0010628 ISO
    negative regulation of muscle cell apoptotic process GO:0010656 IMP
    positive regulation of cholesterol efflux GO:0010875 IEA
    positive regulation of cholesterol efflux GO:0010875 ISO
    negative regulation of smooth muscle cell migration GO:0014912 IMP
    protein transport GO:0015031 IEA
    protein transport GO:0015031 ISO
    vesicle organization GO:0016050 ISO
    receptor-mediated endocytosis of virus by host cell GO:0019065 IEA
    receptor-mediated endocytosis of virus by host cell GO:0019065 ISO
    regulation of fatty acid metabolic process GO:0019217 IEA
    regulation of fatty acid metabolic process GO:0019217 ISO
    cytokine-mediated signaling pathway GO:0019221 IEA
    cytokine-mediated signaling pathway GO:0019221 ISO
    lipid storage GO:0019915 IEA
    lipid storage GO:0019915 ISO
    cell differentiation GO:0030154 IBA
    regulation of blood coagulation GO:0030193 IEA
    regulation of blood coagulation GO:0030193 ISO
    positive regulation of cell migration GO:0030335 IEA
    positive regulation of cell migration GO:0030335 ISO
    negative regulation of BMP signaling pathway GO:0030514 ISO
    negative regulation of epithelial cell differentiation GO:0030857 IEA
    negative regulation of epithelial cell differentiation GO:0030857 ISO
    mammary gland development GO:0030879 ISO
    animal organ regeneration GO:0031100 IEP
    positive regulation of microtubule polymerization GO:0031116 IMP
    T cell costimulation GO:0031295 IEA
    T cell costimulation GO:0031295 ISO
    T cell costimulation GO:0031295 ISS
    negative regulation of protein ubiquitination GO:0031397 IEA
    negative regulation of protein ubiquitination GO:0031397 ISO
    positive regulation of protein ubiquitination GO:0031398 IEA
    positive regulation of protein ubiquitination GO:0031398 ISO
    receptor internalization GO:0031623 ISO
    receptor internalization GO:0031623 ISS
    maintenance of protein location in cell GO:0032507 IMP
    response to progesterone GO:0032570 IEA
    response to progesterone GO:0032570 ISO
    negative regulation of peptidyl-serine phosphorylation GO:0033137 ISO
    positive regulation of peptidyl-serine phosphorylation GO:0033138 ISO
    cholesterol efflux GO:0033344 IMP
    intracellular nitric oxide homeostasis GO:0033484 IEA
    intracellular nitric oxide homeostasis GO:0033484 ISO
    positive regulation of toll-like receptor 3 signaling pathway GO:0034141 IEA
    positive regulation of toll-like receptor 3 signaling pathway GO:0034141 ISO
    insulin receptor internalization GO:0038016 IEA
    insulin receptor internalization GO:0038016 ISO
    angiotensin-activated signaling pathway GO:0038166 IEA
    angiotensin-activated signaling pathway GO:0038166 ISO
    vasoconstriction GO:0042310 IEA
    vasoconstriction GO:0042310 ISO
    negative regulation of tyrosine phosphorylation of STAT protein GO:0042532 ISO
    cholesterol homeostasis GO:0042632 IEA
    cholesterol homeostasis GO:0042632 ISO
    positive regulation of catalytic activity GO:0043085 ISO
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IEA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISO
    negative regulation of MAP kinase activity GO:0043407 ISO
    negative regulation of MAPK cascade GO:0043409 IEA
    negative regulation of MAPK cascade GO:0043409 ISO
    response to estrogen GO:0043627 IEA
    response to estrogen GO:0043627 ISO
    protein localization to plasma membrane raft GO:0044860 ISO
    negative regulation of nitric oxide biosynthetic process GO:0045019 IEA
    negative regulation of nitric oxide biosynthetic process GO:0045019 ISO
    negative regulation of neuron differentiation GO:0045665 IMP
    positive regulation of endocytosis GO:0045807 IMP
    positive regulation of vasoconstriction GO:0045907 IEA
    positive regulation of vasoconstriction GO:0045907 IMP
    positive regulation of vasoconstriction GO:0045907 ISO
    negative regulation of receptor signaling pathway via JAK-STAT GO:0046426 IEA
    negative regulation of receptor signaling pathway via JAK-STAT GO:0046426 ISO
    muscle cell cellular homeostasis GO:0046716 IEA
    muscle cell cellular homeostasis GO:0046716 ISO
    microtubule polymerization GO:0046785 IMP
    fibroblast proliferation GO:0048144 IEA
    fibroblast proliferation GO:0048144 ISO
    negative regulation of fibroblast proliferation GO:0048147 IEA
    negative regulation of fibroblast proliferation GO:0048147 ISO
    negative regulation of pinocytosis GO:0048550 IEA
    negative regulation of pinocytosis GO:0048550 ISO
    negative regulation of smooth muscle cell proliferation GO:0048662 IMP
    negative regulation of nitric-oxide synthase activity GO:0051001 ISO
    response to glucocorticoid GO:0051384 IEP
    regulation of cytosolic calcium ion concentration GO:0051480 IBA
    regulation of cytosolic calcium ion concentration GO:0051480 IEA
    regulation of cytosolic calcium ion concentration GO:0051480 ISO
    response to calcium ion GO:0051592 IEA
    response to calcium ion GO:0051592 ISO
    establishment of localization in cell GO:0051649 IEA
    establishment of localization in cell GO:0051649 ISO
    membrane depolarization GO:0051899 IEA
    membrane depolarization GO:0051899 ISO
    regulation of peptidase activity GO:0052547 ISO
    calcium ion homeostasis GO:0055074 ISO
    mammary gland involution GO:0060056 IEA
    mammary gland involution GO:0060056 ISO
    canonical Wnt signaling pathway GO:0060070 IEA
    canonical Wnt signaling pathway GO:0060070 ISO
    positive regulation of cell adhesion molecule production GO:0060355 IEA
    positive regulation of cell adhesion molecule production GO:0060355 ISO
    negative regulation of necroptotic process GO:0060546 IEA
    negative regulation of necroptotic process GO:0060546 ISO
    negative regulation of ERK1 and ERK2 cascade GO:0070373 IDA
    caveola assembly GO:0070836 IBA
    caveola assembly GO:0070836 IEA
    caveola assembly GO:0070836 ISO
    caveola assembly GO:0070836 ISO
    cellular response to misfolded protein GO:0071218 IEA
    cellular response to misfolded protein GO:0071218 ISO
    cellular response to mechanical stimulus GO:0071260 IDA
    cellular response to exogenous dsRNA GO:0071360 IEA
    cellular response to exogenous dsRNA GO:0071360 ISO
    cellular response to peptide hormone stimulus GO:0071375 ISO
    cellular response to hyperoxia GO:0071455 IEA
    cellular response to hyperoxia GO:0071455 ISO
    cellular response to hypoxia GO:0071456 IEP
    cellular response to transforming growth factor beta stimulus GO:0071560 IEA
    cellular response to transforming growth factor beta stimulus GO:0071560 ISO
    basement membrane organization GO:0071711 IEA
    basement membrane organization GO:0071711 ISO
    caveolin-mediated endocytosis GO:0072584 IEA
    caveolin-mediated endocytosis GO:0072584 ISO
    caveolin-mediated endocytosis GO:0072584 ISO
    regulation of heart rate by cardiac conduction GO:0086091 IEA
    regulation of heart rate by cardiac conduction GO:0086091 ISO
    negative regulation of canonical Wnt signaling pathway GO:0090090 IEA
    negative regulation of canonical Wnt signaling pathway GO:0090090 ISO
    negative regulation of canonical Wnt signaling pathway GO:0090090 ISS
    cellular senescence GO:0090398 IMP
    apoptotic signaling pathway GO:0097190 IEA
    apoptotic signaling pathway GO:0097190 ISO
    regulation of membrane repolarization during action potential GO:0098903 IEA
    regulation of membrane repolarization during action potential GO:0098903 ISO
    regulation of ventricular cardiac muscle cell action potential GO:0098911 IEA
    regulation of ventricular cardiac muscle cell action potential GO:0098911 ISO
    positive regulation of cold-induced thermogenesis GO:0120162 IEA
    positive regulation of cold-induced thermogenesis GO:0120162 ISO
    positive regulation of cold-induced thermogenesis GO:0120162 ISS
    regulation of ruffle assembly GO:1900027 IEA
    regulation of ruffle assembly GO:1900027 ISO
    negative regulation of potassium ion transmembrane transport GO:1901380 IEA
    negative regulation of potassium ion transmembrane transport GO:1901380 ISO
    regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 IEA
    regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 ISO
    protein localization to basolateral plasma membrane GO:1903361 ISO
    positive regulation of gap junction assembly GO:1903598 IEA
    positive regulation of gap junction assembly GO:1903598 ISO
    negative regulation of inward rectifier potassium channel activity GO:1903609 ISO
    positive regulation of ERAD pathway GO:1904294 IEA
    positive regulation of ERAD pathway GO:1904294 ISO
    negative regulation of vascular associated smooth muscle cell proliferation GO:1904706 IMP
    negative regulation of calcium ion import across plasma membrane GO:1905949 IMP
    regulation of entry of bacterium into host cell GO:2000535 IEA
    regulation of entry of bacterium into host cell GO:2000535 ISO
    negative regulation of anoikis GO:2000811 IEA
    negative regulation of anoikis GO:2000811 ISO
    positive regulation of extrinsic apoptotic signaling pathway GO:2001238 IEA
    positive regulation of extrinsic apoptotic signaling pathway GO:2001238 ISO
    positive regulation of intrinsic apoptotic signaling pathway GO:2001244 IEA
    positive regulation of intrinsic apoptotic signaling pathway GO:2001244 ISO
    negative regulation of cation channel activity GO:2001258 IDA
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    Golgi membrane GO:0000139 ISO
    Golgi membrane GO:0000139 ISS
    acrosomal membrane GO:0002080 IEA
    acrosomal membrane GO:0002080 ISO
    caveolar macromolecular signaling complex GO:0002095 IEA
    caveolar macromolecular signaling complex GO:0002095 ISO
    endosome GO:0005768 IEA
    endosome GO:0005768 ISO
    endosome GO:0005768 ISS
    peroxisomal membrane GO:0005778 IDA
    endoplasmic reticulum GO:0005783 IEA
    endoplasmic reticulum GO:0005783 ISO
    endoplasmic reticulum GO:0005783 ISS
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    Golgi apparatus GO:0005794 ISO
    lipid droplet GO:0005811 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    caveola GO:0005901 IDA
    caveola GO:0005901 IEA
    caveola GO:0005901 ISO
    caveola GO:0005901 ISS
    focal adhesion GO:0005925 IDA
    focal adhesion GO:0005925 IEA
    focal adhesion GO:0005925 ISO
    cilium GO:0005929 IEA
    cilium GO:0005929 ISO
    cell cortex GO:0005938 IEA
    cell cortex GO:0005938 ISO
    basal plasma membrane GO:0009925 IDA
    cell surface GO:0009986 IDA
    membrane GO:0016020 ISO
    basolateral plasma membrane GO:0016323 ISO
    apical plasma membrane GO:0016324 ISO
    cytoplasmic vesicle GO:0031410 IBA
    cytoplasmic vesicle GO:0031410 ISO
    protein-containing complex GO:0032991 IDA
    protein-containing complex GO:0032991 ISO
    sarcolemma GO:0042383 IBA
    membrane raft GO:0045121 IDA
    membrane raft GO:0045121 ISO
    perinuclear region of cytoplasm GO:0048471 IBA
    perinuclear region of cytoplasm GO:0048471 IDA
    perinuclear region of cytoplasm GO:0048471 IEA
    perinuclear region of cytoplasm GO:0048471 ISO
    exocytic vesicle GO:0070382 ISO
 Experiment description of studies that identified Cav1 in exosomes
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 92
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|GAPDH|CD9|CD151
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
3
Experiment ID 93
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|GAPDH|CD9|CD151
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Cav1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Strn4  
Affinity Capture-Western Rattus norvegicus
Reconstituted Complex Rattus norvegicus
2 Strn  
Affinity Capture-Western Rattus norvegicus
Reconstituted Complex Rattus norvegicus
3 Strn3  
Affinity Capture-Western Rattus norvegicus
Reconstituted Complex Rattus norvegicus
4 Abcb1b  
Affinity Capture-Western Rattus norvegicus
5 Fbxo21  
Affinity Capture-MS Rattus norvegicus
6 Cav2 363425
FRET Rattus norvegicus
7 HTR2A  
Affinity Capture-Western Homo sapiens
8 Htr2a  
Affinity Capture-Western Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
View the network image/svg+xml
 Pathways in which Cav1 is involved
No pathways found





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