Gene description for Cav2
Gene name caveolin 2
Gene symbol Cav2
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Cav2
ExoCarta ExoCarta_363425
Entrez Gene 363425
UniProt Q2IBC5  
 Cav2 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Cav2
Molecular Function
    phosphoprotein binding GO:0051219 IPI
    syntaxin binding GO:0019905 IDA
    protein binding, bridging GO:0030674 ISO
    D1 dopamine receptor binding GO:0031748 ISS
    protein heterodimerization activity GO:0046982 ISO
    protein kinase binding GO:0019901 ISO
    scaffold protein binding GO:0097110 ISO
    protein binding GO:0005515 IPI
    protein homodimerization activity GO:0042803 ISO
    protein complex scaffold GO:0032947 ISO
    mitogen-activated protein kinase kinase kinase binding GO:0031435 IPI
    SNARE binding GO:0000149 IDA
Biological Process
    receptor-mediated endocytosis of virus by host cell GO:0019065 ISO
    mitochondrion organization GO:0007005 ISS
    insulin receptor signaling pathway GO:0008286 ISO
    positive regulation of MAPK cascade GO:0043410 ISO
    positive regulation of protein localization to nucleus GO:1900182 IDA
    positive regulation of dopamine receptor signaling pathway GO:0060161 ISS
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA
    vesicle organization GO:0016050 ISO
    vesicle fusion GO:0006906 ISS
    positive regulation of endothelial cell proliferation GO:0001938 ISO
    caveola assembly GO:0070836 ISS
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 ISO
    protein oligomerization GO:0051259 ISO
    endoplasmic reticulum organization GO:0007029 ISS
    vesicle docking GO:0048278 ISS
    skeletal muscle fiber development GO:0048741 ISS
    negative regulation of endothelial cell proliferation GO:0001937 ISS
    regulation of mitotic nuclear division GO:0007088 ISO
    positive regulation of GTPase activity GO:0043547 ISO
    negative regulation of cell proliferation GO:0008285 ISO
    synaptic transmission GO:0007268 IDA
Subcellular Localization
    cytosol GO:0005829 IDA
    protein complex GO:0043234 ISO
    acrosomal membrane GO:0002080 ISO
    membrane GO:0016020 ISO
    cell surface GO:0009986 IDA
    nuclear envelope GO:0005635 IDA
    Golgi apparatus GO:0005794 IDA
    Golgi membrane GO:0000139 IEA
    transport vesicle GO:0030133 ISO
    cytoplasm GO:0005737 IDA
    extrinsic component of cytoplasmic side of plasma membrane GO:0031234 ISS
    lipid particle GO:0005811 IDA
    perinuclear region of cytoplasm GO:0048471 ISS
    nuclear inner membrane GO:0005637 IDA
    intracellular GO:0005622 ISO
    integral component of plasma membrane GO:0005887 ISO
    plasma membrane GO:0005886 ISO
    membrane raft GO:0045121 ISO
    focal adhesion GO:0005925 ISO
    cytoplasmic vesicle GO:0031410 ISO
    endoplasmic reticulum GO:0005783 IDA
    caveola GO:0005901 ISS
 Experiment description of studies that identified Cav2 in exosomes
Experiment ID 225
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Cav2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cav2 is involved
No pathways found

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