Gene description for Cav2
Gene name caveolin 2
Gene symbol Cav2
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Cav2
ExoCarta ExoCarta_363425
Entrez Gene 363425
UniProt Q2IBC5  
 Cav2 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Cav2
Molecular Function
    phosphoprotein binding GO:0051219 IPI
    syntaxin binding GO:0019905 IDA
    protein binding, bridging GO:0030674 ISO
    D1 dopamine receptor binding GO:0031748 ISS
    protein heterodimerization activity GO:0046982 ISO
    protein kinase binding GO:0019901 ISO
    scaffold protein binding GO:0097110 ISO
    protein binding GO:0005515 IPI
    protein homodimerization activity GO:0042803 ISO
    protein complex scaffold GO:0032947 ISO
    mitogen-activated protein kinase kinase kinase binding GO:0031435 IPI
    SNARE binding GO:0000149 IDA
Biological Process
    receptor-mediated endocytosis of virus by host cell GO:0019065 ISO
    mitochondrion organization GO:0007005 ISS
    insulin receptor signaling pathway GO:0008286 ISO
    positive regulation of MAPK cascade GO:0043410 ISO
    positive regulation of protein localization to nucleus GO:1900182 IDA
    positive regulation of dopamine receptor signaling pathway GO:0060161 ISS
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA
    vesicle organization GO:0016050 ISO
    vesicle fusion GO:0006906 ISS
    positive regulation of endothelial cell proliferation GO:0001938 ISO
    caveola assembly GO:0070836 ISS
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 ISO
    protein oligomerization GO:0051259 ISO
    endoplasmic reticulum organization GO:0007029 ISS
    vesicle docking GO:0048278 ISS
    skeletal muscle fiber development GO:0048741 ISS
    negative regulation of endothelial cell proliferation GO:0001937 ISS
    regulation of mitotic nuclear division GO:0007088 ISO
    positive regulation of GTPase activity GO:0043547 ISO
    negative regulation of cell proliferation GO:0008285 ISO
    synaptic transmission GO:0007268 IDA
Subcellular Localization
    cytosol GO:0005829 IDA
    protein complex GO:0043234 ISO
    acrosomal membrane GO:0002080 ISO
    membrane GO:0016020 ISO
    cell surface GO:0009986 IDA
    nuclear envelope GO:0005635 IDA
    Golgi apparatus GO:0005794 IDA
    Golgi membrane GO:0000139 IEA
    transport vesicle GO:0030133 ISO
    cytoplasm GO:0005737 IDA
    extrinsic component of cytoplasmic side of plasma membrane GO:0031234 ISS
    lipid particle GO:0005811 IDA
    perinuclear region of cytoplasm GO:0048471 ISS
    nuclear inner membrane GO:0005637 IDA
    intracellular GO:0005622 ISO
    integral component of plasma membrane GO:0005887 ISO
    plasma membrane GO:0005886 ISO
    membrane raft GO:0045121 ISO
    focal adhesion GO:0005925 ISO
    cytoplasmic vesicle GO:0031410 ISO
    endoplasmic reticulum GO:0005783 IDA
    caveola GO:0005901 ISS
 Experiment description of studies that identified Cav2 in exosomes
1
Experiment ID 225
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Cav2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cav2 is involved
No pathways found





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