Gene description for Dnm2
Gene name	dynamin 2
Gene symbol	Dnm2
Other names/aliases	DYIIAAB
Species	Rattus norvegicus
Database cross references - Dnm2
ExoCarta	ExoCarta_25751
Vesiclepedia	VP_25751
Entrez Gene	25751
UniProt	P39052
Dnm2 identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Dnm2

Molecular Function     GTPase activity GO:0003924 IBA     GTPase activity GO:0003924 IDA     GTPase activity GO:0003924 IEA     GTPase activity GO:0003924 ISO     GTPase activity GO:0003924 TAS     protein binding GO:0005515 IPI     GTP binding GO:0005525 IEA     GTP binding GO:0005525 TAS     phosphatidylinositol-4,5-bisphosphate binding GO:0005546 IEA     phosphatidylinositol-4,5-bisphosphate binding GO:0005546 ISO     phosphatidylinositol-4,5-bisphosphate binding GO:0005546 ISS     microtubule binding GO:0008017 IBA     SH3 domain binding GO:0017124 IEA     SH3 domain binding GO:0017124 IPI     SH3 domain binding GO:0017124 ISO     protein kinase binding GO:0019901 IPI     D2 dopamine receptor binding GO:0031749 IPI     phosphatidylinositol 3-kinase regulatory subunit binding GO:0036312 IDA     protein-containing complex binding GO:0044877 IDA     WW domain binding GO:0050699 IPI     nitric-oxide synthase binding GO:0050998 IDA     protein serine/threonine kinase binding GO:0120283 IPI     membrane scission GTPase motor activity GO:1990606 IEA Biological Process     G protein-coupled receptor internalization GO:0002031 IMP     ventricular septum development GO:0003281 ISO     Golgi to plasma membrane transport GO:0006893 IMP     endocytosis GO:0006897 IEA     endocytosis GO:0006897 ISO     endocytosis GO:0006897 TAS     receptor-mediated endocytosis GO:0006898 IDA     receptor-mediated endocytosis GO:0006898 IMP     receptor-mediated endocytosis GO:0006898 ISO     phagocytosis GO:0006909 IEA     autophagy GO:0006914 IEA     autophagy GO:0006914 ISO     autophagy GO:0006914 ISS     centrosome cycle GO:0007098 IMP     spermatogenesis GO:0007283 IEP     response to light stimulus GO:0009416 IEP     positive regulation of lamellipodium assembly GO:0010592 IMP     synaptic vesicle budding from presynaptic endocytic zone membrane GO:0016185 IBA     negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IMP     regulation of axon extension GO:0030516 IMP     receptor internalization GO:0031623 IBA     receptor internalization GO:0031623 IEA     receptor internalization GO:0031623 ISO     transferrin transport GO:0033572 IEA     transferrin transport GO:0033572 ISO     regulation of Rac protein signal transduction GO:0035020 IMP     aorta development GO:0035904 ISO     response to cocaine GO:0042220 IEP     stress fiber assembly GO:0043149 IMP     macropinocytosis GO:0044351 IMP     positive regulation of nitric oxide biosynthetic process GO:0045429 IMP     positive regulation of endocytosis GO:0045807 IMP     synaptic vesicle endocytosis GO:0048488 ISO     neuron projection morphogenesis GO:0048812 IMP     positive regulation of phagocytosis GO:0050766 IMP     protein polymerization GO:0051258 IEA     protein polymerization GO:0051258 IMP     protein polymerization GO:0051258 ISO     protein polymerization GO:0051258 ISS     coronary vasculature development GO:0060976 ISO     actin filament bundle organization GO:0061572 IEA     actin filament bundle organization GO:0061572 IMP     actin filament bundle organization GO:0061572 ISO     actin filament bundle organization GO:0061572 ISS     cellular response to carbon monoxide GO:0071245 IEP     cellular response to X-ray GO:0071481 IEP     cellular response to nitric oxide GO:0071732 IEP     membrane tubulation GO:0097749 IEA     membrane tubulation GO:0097749 IMP     membrane tubulation GO:0097749 ISO     membrane tubulation GO:0097749 ISS     vesicle scission GO:0099050 IEA     vesicle scission GO:0099050 ISO     vesicle scission GO:0099050 ISS     postsynaptic endocytosis GO:0140239 EXP     postsynaptic endocytosis GO:0140239 IDA     postsynaptic endocytosis GO:0140239 IMP     positive regulation of substrate adhesion-dependent cell spreading GO:1900026 IMP     negative regulation of non-motile cilium assembly GO:1902856 IMP     cellular response to dopamine GO:1903351 IDA     regulation of Golgi organization GO:1903358 IMP     positive regulation of P-type sodium:potassium-exchanging transporter activity GO:1903408 IMP     negative regulation of membrane tubulation GO:1903526 IEA     negative regulation of membrane tubulation GO:1903526 ISO     positive regulation of clathrin-dependent endocytosis GO:2000370 IMP Subcellular Localization     Golgi membrane GO:0000139 IDA     phagocytic cup GO:0001891 IDA     photoreceptor inner segment GO:0001917 ISO     uropod GO:0001931 IEA     uropod GO:0001931 ISO     uropod GO:0001931 ISS     podosome GO:0002102 IEA     cytoplasm GO:0005737 IBA     endosome GO:0005768 IDA     endosome GO:0005768 ISO     Golgi apparatus GO:0005794 IEA     Golgi apparatus GO:0005794 ISO     trans-Golgi network GO:0005802 IDA     centrosome GO:0005813 IDA     centrosome GO:0005813 IEA     centrosome GO:0005813 ISO     centriole GO:0005814 IEA     centriole GO:0005814 ISO     centriole GO:0005814 ISS     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     cytosol GO:0005829 TAS     microtubule GO:0005874 IBA     microtubule GO:0005874 IEA     microtubule GO:0005874 ISO     microtubule GO:0005874 ISS     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 TAS     clathrin-coated pit GO:0005905 IDA     clathrin-coated pit GO:0005905 ISO     cell cortex GO:0005938 ISO     postsynaptic density GO:0014069 IDA     lamellipodium GO:0030027 IDA     cell junction GO:0030054 IDA     clathrin-coated vesicle GO:0030136 IDA     clathrin-coated vesicle GO:0030136 IEA     clathrin-coated vesicle GO:0030136 ISO     growth cone GO:0030426 IDA     midbody GO:0030496 IEA     phagocytic vesicle membrane GO:0030670 IEA     ruffle membrane GO:0032587 IDA     protein-containing complex GO:0032991 IDA     neuron projection GO:0043005 IDA     neuron projection GO:0043005 IEA     synapse GO:0045202 IBA     postsynaptic membrane GO:0045211 IEA     postsynaptic membrane GO:0045211 ISO     postsynaptic membrane GO:0045211 ISS     clathrin-coated endocytic vesicle GO:0045334 IDA     perinuclear region of cytoplasm GO:0048471 IDA     recycling endosome GO:0055037 IEA     recycling endosome GO:0055037 ISO     recycling endosome GO:0055037 ISS     anchoring junction GO:0070161 IEA     meiotic spindle GO:0072687 ISO     postsynaptic endocytic zone GO:0098843 IDA     postsynaptic endocytic zone GO:0098843 IMP     glutamatergic synapse GO:0098978 EXP     glutamatergic synapse GO:0098978 IDA     glutamatergic synapse GO:0098978 IMP     postsynaptic density, intracellular component GO:0099092 IDA     postsynaptic density, intracellular component GO:0099092 IMP