Gene description for SLC9C1
Gene name solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1
Gene symbol SLC9C1
Other names/aliases NHE
SLC9A10
sperm-NHE
Species Homo sapiens
 Database cross references - SLC9C1
ExoCarta ExoCarta_285335
Entrez Gene 285335
HGNC 31401
MIM 612738
UniProt Q4G0N8  
 SLC9C1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for SLC9C1
Molecular Function
    solute:proton antiporter activity GO:0015299 IEA
Biological Process
    ion transmembrane transport GO:0034220 TAS
    hydrogen ion transmembrane transport GO:1902600 IEA
    cell differentiation GO:0030154 IEA
    transmembrane transport GO:0055085 TAS
    sodium ion transport GO:0006814 IEA
    spermatogenesis GO:0007283 IEA
    sperm motility GO:0030317 IEA
    multicellular organismal development GO:0007275 IEA
Subcellular Localization
    motile cilium GO:0031514 IEA
    plasma membrane GO:0005886 IEA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified SLC9C1 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for SLC9C1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SLC9C1 is involved
PathwayEvidenceSource
Stimuli-sensing channels TAS Reactome





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