Gene description for DOK7
Gene name docking protein 7
Gene symbol DOK7
Other names/aliases C4orf25
CMS10
CMS1B
Species Homo sapiens
 Database cross references - DOK7
ExoCarta ExoCarta_285489
Entrez Gene 285489
HGNC 26594
MIM 610285
UniProt Q18PE1  
 DOK7 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for DOK7
Molecular Function
    insulin receptor binding GO:0005158 IEA
    phosphatidylinositol binding GO:0035091 IEA
    protein kinase binding GO:0019901 IDA
Biological Process
    positive regulation of protein tyrosine kinase activity GO:0061098 IDA
    receptor clustering GO:0043113 IEA
    neuromuscular junction development GO:0007528 IEA
Subcellular Localization
    cell junction GO:0030054 IEA
    plasma membrane GO:0005886 IEA
    neuromuscular junction GO:0031594 IEA
 Experiment description of studies that identified DOK7 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for DOK7
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which DOK7 is involved
No pathways found





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